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Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease

Lischalk, Jonathan W; Blacksburg, Seth; Mendez, Christopher; Repka, Michael; Sanchez, Astrid; Carpenter, Todd; Witten, Matthew; Garbus, Jules E; Evans, Andrew; Collins, Sean P; Katz, Aaron; Haas, Jonathan
BACKGROUND:Historically, IBD has been thought to increase the underlying risk of radiation related toxicity in the treatment of prostate cancer. In the modern era, contemporary radiation planning and delivery may mitigate radiation-related toxicity in this theoretically high-risk cohort. This is the first manuscript to report clinical outcomes for men diagnosed with prostate cancer and underlying IBD curatively treated with stereotactic body radiation therapy (SBRT). METHODS:A large institutional database of patients (n = 4245) treated with SBRT for adenocarcinoma of the prostate was interrogated to identify patients who were diagnosed with underlying IBD prior to treatment. All patients were treated with SBRT over five treatment fractions using a robotic radiosurgical platform and fiducial tracking. Baseline IBD characteristics including IBD subtype, pre-SBRT IBD medications, and EPIC bowel questionnaires were reviewed for the IBD cohort. Acute and late toxicity was evaluated using the CTCAE version 5.0. RESULTS:A total of 31 patients were identified who had underlying IBD prior to SBRT for the curative treatment of prostate cancer. The majority (n = 18) were diagnosed with ulcerative colitis and were being treated with local steroid suppositories for IBD. No biochemical relapses were observed in the IBD cohort with early follow up. High-grade acute and late toxicities were rare (n = 1, grade 3 proctitis) with a median time to any GI toxicity of 22 months. Hemorrhoidal flare was the most common low-grade toxicity observed (n = 3). CONCLUSION/CONCLUSIONS:To date, this is one of the largest groups of patients with IBD treated safely and effectively with radiation for prostate cancer and the only review of patients treated with SBRT. Caution is warranted when delivering therapeutic radiation to patients with IBD, however modern radiation techniques appear to have mitigated the risk of GI side effects.
PMID: 34243797
ISSN: 1748-717x
CID: 4965222

Low Body Mass Index As a Risk Factor for Long-Term Proctitis after Prostate SBRT: Assessing the Dosimetric and Clinical Implications [Meeting Abstract]

Blacksburg, S. R.; Sheu, R.; Carpenter, T. J.; Demircioglu, G.; Witten, M. R.; Mendez, C.; Ilyas, A.; Dodin, F.; Chieng, T.; Garbus, J.; Pappas, D.; Haas, J. A.
ISSN: 0360-3016
CID: 4686382

Predictors of Rectal Toxicity in Patients Receiving Prostate SBRT: The Effect of Intrafraction Rotation [Meeting Abstract]

Blacksburg, S. R.; Sheu, R.; Carpenter, T. J.; Demircioglu, G.; Mirza, A.; Coakley, M.; Mieles, M.; Murray, A. O.; Mendez, C.; Witten, M. R.; Garbus, J.; Pappas, D.; Haas, J. A.
ISSN: 0360-3016
CID: 4111342

Improving uniformity of care for colorectal cancers through National Quality Forum quality indicators at a Commission on Cancer-accredited community based teaching hospital

Pappas, Dean P; Garbus, Jules E; Feuerman, Martin; Reed, William P
The National Cancer Data Base (NCDB) provides feedback on adherence to National Quality Forum (NQF)-endorsed measures to promote best outcomes in colorectal cancer. We examined the care delivered to patients with colorectal cancer at our institution and developed a protocol to enhance nodal retrieval and to ensure that patients with fewer than 12 nodes are considered for adjuvant chemotherapy. Few patients met the NQF criteria for adjuvant radiation. A protocol was developed to address this issue, and this provides a model for use in a multidisciplinary effort to improve adherence to measures associated with best outcomes in colorectal cancer.
PMID: 21640923
ISSN: 1558-5042
CID: 5019372

Current controversies in pouch surgery

Garbus, Jules E; Potenti, Fabio; Wexner, Steven D
Restorative proctocolectomy with ileal pouch anal anastomosis has become the most commonly used procedure for elective treatment of patients with mucosal ulcerative colitis and familial adenomatous polyposis. Since its original description, the procedure has been modified in an attempt to obtain optimal functional results with low morbidity and mortality, and yet provide a cure for the disease. These modifications of the technique are discussed in this review, limited to the current points of controversy. We reviewed the current literature describing restorative proctocolectomy with ileal pouch anal anastomosis. The current "hot topics" for debate are transanal mucosectomy with hand-sewn anastomosis versus the double-stapled technique, the use of diverting ileostomy, indeterminate colitis, the role of laparoscopy, and indications for pouch surgery in the elderly. Longer follow-up of patients and increased knowledge and experience with pouch surgery, coupled with active prospective evaluation of the procedure are required to settle these issues. Patients must be fully informed to understand inherent risks of each choice.
PMID: 12602710
ISSN: 0038-4348
CID: 5019362