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Real-World Clinical Impact of Netarsudil 0.02% at an Urban Safety-Net Hospital

Fridman, Gabrielle; Sadlak, Natalie; Eliassi-Rad, Babak; Desai, Manishi A
PMID: 33983847
ISSN: 1557-7732
CID: 5274912

Delayed-onset seesaw nystagmus following brain irradiation [Case Report]

Fridman, Gabrielle; Distefano, Alberto
PMID: 34512208
ISSN: 1542-8958
CID: 5274922

Pseudo-Duane retraction syndrome after orbital myositis [Case Report]

Elhusseiny, Abdelrahman M; Fridman, Gabrielle; Nihalani, Bharti R; Gaier, Eric D
Orbital myositis is a rare, commonly idiopathic, inflammatory condition that affects one or more extraocular muscles. We present a case of unilateral orbital myositis affecting the lateral rectus muscle presenting with gaze-evoked amaurosis, pain, and diplopia, with restrictive limitation of adduction. With improvement in adduction after initiating treatment, we noted narrowing of the palpebral fissure on attempted adduction, mimicking Duane retraction syndrome (DRS). Reported cases of "pseudo-DRS" are associated with multiple etiologies and are characterized by retraction on attempted abduction rather than adduction, as occurs in true DRS. In this case, pseudo-DRS occurred in the setting of idiopathic orbital inflammatory syndrome (orbital myositis) with a motility pattern more consistent with true DRS.
PMID: 33652102
ISSN: 1528-3933
CID: 5274902

New-onset anterior uveitis in two patients on ustekinumab for inflammatory bowel disease [Case Report]

Fridman, Gabrielle; LaMaattina, Kara C
ISSN: 2772-3089
CID: 5308682

Ocular Syphilis Trend in Urban Underserved Community in the United States [Meeting Abstract]

Tam, Emily; Fridman, Gabrielle; Port, Alexander; Siegel, Nicole Hauptman
ISSN: 0146-0404
CID: 5274942

Features of pentosan polysulfate sodium-associated maculopathy in a diverse patient population [Meeting Abstract]

Fridman, Gabrielle; Tam, Emily K.; Port, Alexander; Siegel, Nicole Hauptman
ISSN: 0146-0404
CID: 5274932

Novel Mutation in Retinitis Pigmentosa GTPase Regulator Gene Causes Primary Ciliary Dyskinesia and Retinitis Pigmentosa [Case Report]

Sengillo, Jesse D; Fridman, Gabrielle; Cho, Galaxy Y; Buchovecky, Christie; Tsang, Stephen H
The majority of X-linked retinitis pigmentosa (XLRP) is due to mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. Determining the pathogenicity of novel variants is important for enrollment of patients into gene therapy trials. Sequencing and analysis of RPGR variants in ORF15 is challenging, as it is highly repetitive and rich in purines. Overlapping reading frames and polymorphic insertions / deletions add further complexity to the detection of mutations. Identifying systemic manifestations in affected males and carrier phenotype in related females expedites confirmation of pathogenic variants. The authors present a 16-year-old boy with a history of primary ciliary dyskinesia presenting with complaints of nyctalopia and visual field constriction. Multimodal imaging found peripheral thinning of the retina and a characteristic foveal hyperautofluorescent ring in the proband, and a carrier phenotype in the asymptomatic mother. A novel c.1059_1059+2delGGT, p.(?) variant in RPGR was identified as hemizygous in the affected boy and heterozygous in his mother. This case study expands the genotypic spectrum of RPGR variants associated with systemic manifestations. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:548-552.].
PMID: 30021045
ISSN: 2325-8179
CID: 5274892

Corneal transplant rejection after initiation of systemic antineoplastic agents [Case Report]

Rohr, Ashley; Fridman, Gabrielle; Sengillo, Jesse D; Schrier, Amilia
ISSN: 2214-1677
CID: 5308692

Clinical characterization of a COL2A1 variant manifesting solely in the retina [Meeting Abstract]

Fridman, Gabrielle; Sengillo, Jesse D.; Tsang, Stephen H.
ISSN: 0146-0404
CID: 5274952

Model systems for the study of steroid-induced IOP elevation

Rybkin, Ilya; Gerometta, Rosana; Fridman, Gabrielle; Candia, Oscar; Danias, John
Steroid-induced IOP elevation affects a significant number of patients. It results from a decrease in outflow facility of the aqueous humor. To understand the pathophysiology of this condition a number of model systems have been created. These include ex-vivo cell and organ cultures as well as in-vivo animal models in organisms ranging from rodents to primates. These model systems can be used to investigate specific aspects of steroid-induced IOP elevation. This brief review summarizes the strengths and limitations of the various model systems and provides examples of where these systems have been successfully used to advance our understanding of steroid-induced IOP elevation.
PMID: 27450911
ISSN: 1096-0007
CID: 5274882