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Lifestyle Interventions for Major Depressive Disorder (MDD): An Expert Consensus Statement From the American College of Lifestyle Medicine
Merlo, Gia; Sugden, Steve; Rosenfeld, Richard M; Baron, David; Karlsen, Micaela C; Keyes, Sarah-Ann; McHugh, John P; Miller, Lawrence A; Nemeroff, Charles B; Ramas, Marie-Elizabeth; Staffier, Kara L; Williams, Kim A; Wilson, Kathleen P; Wong, William T; Viswanathan, Ramaswamy
PMCID:12783037
PMID: 41523150
ISSN: 1559-8284
CID: 5985912
Connectedness: The Updated and Expanded Pillar of Lifestyle Psychiatry and Lifestyle Medicine
Merlo, Gia; Snellman, Lilly; Sugden, Steven G
The field of Lifestyle Psychiatry aims to prevent, treat, and sometimes reverse chronic physical and mental health conditions through evidence-based interventions. The foundational pillars of this field are physical activity & exercise, nutrition, restorative sleep, stress management, toxic exposure reduction, and connectedness. Connection has been defined as "feeling part of something larger than yourself, feeling close to another person or group, feeling welcomed, and understood." Within Lifestyle Psychiatry, however, we emphasize that connectedness encompasses not only our relationships with other individuals but also our connection to ourselves and with the world at large. We have identified these three relationships as three core or pivotal needs. Similarly, we have expanded our previous model of connectedness to include six domains: (1) Happiness, (2) Purpose in Life & Meaning-Making, (3) Empathy & Compassion, (4) Social Connection & Community, (5) Nature, and (6) Spirituality & Religion. In this paper, we present psychological and scientific data supporting the necessity of the six domains of connectedness. By combining the six domains with the three core needs, practitioners of lifestyle psychiatry can develop impactful and sustainable interventions that promote connectedness, decrease negative health outcomes, and promote psychological growth through increasing resilience, emotional development, and the ability to be alone without loneliness.
PMCID:12129969
PMID: 40469950
ISSN: 1559-8284
CID: 5862652
Gut microbiota, nutrition, and mental health
Merlo, Gia; Bachtel, Gabrielle; Sugden, Steven G
The human brain remains one of the greatest challenges for modern medicine, yet it is one of the most integral and sometimes overlooked aspects of medicine. The human brain consists of roughly 100 billion neurons, 100 trillion neuronal connections and consumes about 20-25% of the body's energy. Emerging evidence highlights that insufficient or inadequate nutrition is linked to an increased risk of brain health, mental health, and psychological functioning compromise. A core component of this relationship includes the intricate dynamics of the brain-gut-microbiota (BGM) system, which is a progressively recognized factor in the sphere of mental/brain health. The bidirectional relationship between the brain, gut, and gut microbiota along the BGM system not only affects nutrient absorption and utilization, but also it exerts substantial influence on cognitive processes, mood regulation, neuroplasticity, and other indices of mental/brain health. Neuroplasticity is the brain's capacity for adaptation and neural regeneration in response to stimuli. Understanding neuroplasticity and considering interventions that enhance the remarkable ability of the brain to change through experience constitutes a burgeoning area of research that has substantial potential for improving well-being, resilience, and overall brain health through optimal nutrition and lifestyle interventions. The nexus of lifestyle interventions and both academic and clinical perspectives of nutritional neuroscience emerges as a potent tool to enhance patient outcomes, proactively mitigate mental/brain health challenges, and improve the management and treatment of existing mental/brain health conditions by championing health-promoting dietary patterns, rectifying nutritional deficiencies, and seamlessly integrating nutrition-centered strategies into clinical care.
PMCID:10884323
PMID: 38406183
ISSN: 2296-861x
CID: 5722462
Deprescribing Following Access to Lifestyle Treatment: A Retrospective Chart Review of Primary Care Outcomes in Patients with Type 2 Diabetes
Jacob, Yoav; Staffier, Kara L; Menon, Samveda; Gandhi, Puja B; MacField, Joeita F; Merlo, Gia; Meyer, Stefanie M; Patel, Shivani S; Rhéaume, Caroline; Watson, Madeline; Donohue, David; Dysinger, Wayne S; Karlsen, Micaela C
PMCID:13074110
PMID: 41976866
ISSN: 2077-0383
CID: 6027632
The Development of a Framework to Classify Medication Deprescribing Among Patients with Type 2 Diabetes in Primary Care Practices
Gandhi, Puja B; Jacob, Yoav; MacField, Joeita F; Merlo, Gia; Meyer, Stefanie M; Patel, Shivani S; Rhéaume, Caroline; Staffier, Kara L; Watson, Madeline; Karlsen, Micaela C
PMCID:13074168
PMID: 41976825
ISSN: 2077-0383
CID: 6027622
Diagnosis Disclosure and Related Illness Experience in Patients With Multiple Myeloma and Precursor Plasma Cell Disorders
Malik, Maria A; Dalvi, Akshay A; Derkach, Andriy; Martínez, Jorge A; Hydren, Jay R; Merlo, Gia; Aldana, Ana M; Ahlstrom, Jennifer M; Usmani, Saad Z; Chimonas, Susan; Ortiz, Robin; Shah, Urvi A
BACKGROUND:Social support is associated with improved prognosis and quality of life after a cancer diagnosis. However, less is known about patients' experiences with disclosing their diagnosis to access support. This study investigated diagnosis disclosure patterns and the illness experiences of patients with multiple myeloma and precursor plasma cell disorders. METHODS:A 34-question survey was distributed between April-November 2023 to patients with plasma cell disorders via HealthTree Foundation's Patient Portal. Deidentified survey responses were analyzed using summary statistics, Fisher's exact test for group comparisons, and qualitative coding of open-ended answers. RESULTS:Among 510 survey respondents, 98% shared their diagnosis. Of these (n = 501), most shared within a day or week (88%), primarily in person (86%), and most frequently with spouses/partners (81%) and friends (81%). Sharers reported improved coping (84%) and stronger relationships (55%), whereas nonsharers (n = 9) reported feeling more isolated (56%). The majority of sharers (87%) did not regret disclosing their diagnosis to anyone. Compared to patients with multiple myeloma (n = 328; 78%), patients with precursor disorders (n = 44; 56%) were less likely to report coping well with their diagnosis (P < .001). Overall, participants advised newly diagnosed patients to consider disclosure timing, prioritize sharing with close contacts, maintain privacy, and educate themselves before sharing. CONCLUSION/CONCLUSIONS:Patients considered diagnosis disclosure to be beneficial to their coping and relationships, and recommended considering various factors when disclosing, including timing, personal relationships, and privacy. Patients with precursor disorders were less likely to indicate they were coping well, suggesting that this group may benefit from additional support resources.
PMID: 42020274
ISSN: 2152-2669
CID: 6032872
Lifestyle psychiatry: a conceptual framework for application in mental healthcare and support
Deenik, Jeroen; Vermeulen, Jentien M; Teasdale, Scott B; Schuch, Felipe Barreto; Marx, Wolfgang; Perry, Ben; Diez, Gustavo G; Castellanos, Nazareth; Elshazly, Mohamed; Gatera, Grace; Waugh, Matt; Hepsomali, Piril; Bueno-Antequera, Javier; Borrueco Sánchez, Jesús; Lopez Moral, Alvaro; López-Sánchez, Camilo; Oviedo Caro, Miguel Angel; Dejonge, Melissa; Noortman, Chermaine; van Schothorst, Myrthe; den Bleijker, Natascha; Scrivano, Luana; Noordsy, Douglas L; Fabian, Hannah; Jachyra, Patrick; Chapman, Justin; Merlo, Gia; Manger, Sam; O'neill, Adrienne; Machaczek, Katarzyna Karolina; Ardill-Young, Oliver; Ramírez, Paula; Matthews, Evan; Lambert, Jeffrey; Firth, Josh; Hassan, Lamiece; Jacka, Felice N; Ward, Philip; Stubbs, Brendon; Cahn, Wiepke; Rosenbaum, Simon; Vancampfort, Davy; Firth, Joseph
Lifestyle-related behaviours-such as sedentary behaviour, physical inactivity, poor nutrition, disrupted sleep and substance use-are increasingly recognised as important factors in the onset and persistence of mental illness. Evidence for the efficacy and cost-efficiency of lifestyle interventions in mental health is growing, and such approaches are now embedded in international guidelines and endorsed by major health organisations and associations as 'lifestyle psychiatry'. Nevertheless, despite this progress, these interventions remain underused in mental healthcare and support. One contributing factor is the lack of a shared conceptual understanding of 'lifestyle psychiatry', which risks fragmented practice, inconsistency in research and uncertainty around its role in policy, care and support. This paper presents a conceptual framework for lifestyle psychiatry, developed through an iterative, collaborative process involving 43 contributors across 15 countries, representing clinical, academic, policy and lived experience expertise. The framework defines core domains, outlines key challenges to behaviour change specific to mental health populations and emphasises multilevel and equity-oriented approaches. It aligns with person-centred and recovery-oriented care and serves as a shared reference point for practical application and future development. With this, we aim to support the structured, context-sensitive integration of lifestyle psychiatry into mental healthcare and support.
PMCID:12658517
PMID: 41290362
ISSN: 2755-9734
CID: 5967452
The Power of Lifestyle Psychiatry: A New Approach to Mental Health
Merlo, Gia; Sugden, Steven G
The field of psychiatry has evolved over the past 2500 years. Between dynamic psychotherapy and psychopharmacology, lifestyle psychiatry holds a different space. This approach capitalizes on the lifestyle medicine movement, as it promotes change within 6 domains of activity. Apart from incorporating these lifestyle pillars as adjunctive therapy for either psychodynamic therapy or psychotropic medication regimens, lifestyle psychiatry is on the frontier similar to the other growing fields of precision psychiatry, advanced learning in psychiatry, psychedelics in psychiatry, digital mental health, and psychiatric genetics. Any disruption into the historical practice of psychiatry, particularly with the prescription of medications, can be met with scrutiny. We encourage the field of psychiatry to keep an open mind as our field continues to evolve. What makes lifestyle psychiatry particularly powerful and unique in its ability to assess and evaluate internal and external factors that contribute to individual behaviors, and may impact the ability to incorporate healthy lifestyle actions. Internal factors include: emotional regulation, internalized trauma, cognitive factors, and personality traits. On the other hand, external factors include environmental barriers and work-related burnout.
PMCID:12009272
PMID: 40260228
ISSN: 1559-8284
CID: 5830072
Health disparities and climate change in the Marshall Islands
Pollard, Kathryn J; Davis, Cory; Davis, Brenda; Donohue, David; Wong, William; Saad, Ali; Merlo, Gia; Pathak, Neha
The small island nations, territories, and states dotting the Pacific are among the most disproportionately affected populations worldwide in the face of climate change. Sea level rise coupled with increased tropical storms contribute to seawater incursion, flooding, personal injury, trauma, and death. They face an existential threat due to the consequences of global warming, specifically ice melt resulting in sea level rise, repercussions for which they are not historically culpable. Along with these environmental threats, Pacific Island communities are further burdened with high rates of adverse health conditions such as diabetes and obesity yet have limited healthcare resources due to minimal economic development. The Republic of the Marshall Islands (RMI) has one of the highest amputation rates worldwide due to advanced diabetes from lifestyle factors, limited healthcare infrastructure, financial disparities, and a culturally based hesitancy to seek medical attention, all of which lead to an increased incidence of diabetic complications. Challenges posed by non-communicable chronic diseases include diabetes and infectious diseases like tuberculosis, hepatitis, malaria, and Zika. Just as crucial to the narrative of the Marshallese people is a fundamental indigenous knowledge of their surroundings and an inseparable relationship to the environment, aquatic animals, and communities around them, denoting a holistic living system. Though the outlook is precarious, solutions centering on lifestyle interventions that are informed by Indigenous cultural strengths can provide a responsive framework and a ray of hope, offering potential solutions to these two. This short perspective highlights the RMI as a case study of the challenges the Pacific Island nations bear, from a legacy of annexation to the modern threat of climate change, compounded by health disparities.
PMID: 39391950
ISSN: 1365-2060
CID: 5706282
What do Climate Change, Nutrition, and the Environment Have to do With Mental Health?
Sugden, Steven G; Merlo, Gia
Climate change is becoming the most significant global challenge and must be addressed on a global scale. At the time that this article is being written, the planetary heat in 2023 was the hottest on record. Similarly, the World Health Organization reports that 99% of the world's population lives in regions of unhealthy air pollution. Similarly, depression has become one of the leading causes of global mental and physical disabilities, and the impact of depression is predicted to only worsen over the next 25 years. It is interesting to note that climate experts often overlook the adoption of nutrition via a whole plant-based diet as a solution to both mental illness and climate change. In this review, we will touch upon the role of nutrition in gut microbiota and mental health, the impact diet has on greenhouse gases, the role of ultra-processed food, and environmental factors such as air pollution and increasing planetary heat and their growing impacts on mental health. In the end, the promotion of plant-based foods has the potential to improve personal mental and physical health while improving planetary health.
PMCID:11562465
PMID: 39554939
ISSN: 1559-8284
CID: 5758062