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Proposed Modifiable Scoring Criteria for Studies Included in Meta-Analyses to Reduce Measurement Bias [Editorial]
Vizgan, Gabriel; von Simson, Bernard; Nicholson, Joey; Gold-von Simson, Gabrielle
Due to inconsistencies in literature reporting, there is potential for bias in meta-regression calculations used in systematic reviews and meta-analyses. To address this, we propose a novel modifiable point-based scoring system, highlighting to readers the scientific weight of included studies relative to the conclusion of the review's authors. Such a scoring system will have the added benefit of also highlighting data points that are underrepresented. This system is ideal for synthesizing reviews on pathologies poorly represented in the literature. The scoring system described will decrease bias and enable impactful interpretation to ultimately lead to standard practice adaptation.
PMCID:12164953
PMID: 40519423
ISSN: 2168-8184
CID: 5870692
Building a community-centered clinical research center in an underserved New York City neighborhood to enhance access to research, equity, and quality of care
Yakubov, Amin; Holahan, James; Lord, Aaron; Jay, Melanie; Gross, Rachel; Engelson, Celia; Alvarez, Zariya; Rodriguez, Miguel; Caba Caceres, Leomaris; Reyes, Michael; Drum, Emily; Xing, Xiaoting; Medina, Rosario; Londhe, Shilpa; Roy, Brita; Alsayed, Imad; Gold-von Simson, Gabrielle; Bredella, Miriam A
Access to an academic clinical research center (CRC) in health professional shortage areas (HPSA) can help address healthcare disparities and increase research accessibility and enrollment. Here we describe the development of a community-centered CRC in the underserved area of Sunset Park, Brooklyn, New York, centered within a larger academic health network and the evaluation of its outcomes within the first two years. In addition to resources and space, establishment of the CRC required a culturally competent and multilingual team of healthcare professionals and researchers and buy-in from the community. Between 1/2022 and 12/2023, the CRC opened 21 new trials (10 interventional and 11 noninterventional) with greater than 500 participant visits that reflect the racial and ethnic diversity of the community. These participants represent 110 distinct zip codes; 76% of these zip codes are underserved and designated HPSA. 60% self-identified as non-White and 20% identified as Hispanic, with 12 other distinct ethnicities represented. 28% of participants speak 11 languages other than English. Community-based CRCs can be created with sustainable growth to align with the mission of the National Institutes of Health and U.S. Food and Drug Administration to meet the ever-growing clinical, social, and research needs of the communities they serve.
PMCID:11975791
PMID: 40201636
ISSN: 2059-8661
CID: 5823822
Sharing best practices for educational programs on venture creation and commercialization
Eidlisz, Jordan; Hill-Whilton, Zachary; Vizgan, Gabriel; Cobos, Daniel; Chitale, Sadhana; Gillespie, Colleen; Dib, Nabil; Gold-von Simson, Gabrielle
PMID: 38632442
ISSN: 1546-1696
CID: 5734502
Exploring the current state of technology transfer in the United States: perspectives and improvement strategies from the experts
Eidlisz, Jordan; von Simson, Isabelle; Gold-von Simson, Gabrielle
Technology transfer (TT) is a necessary, yet complex process to convey and disseminate scientific knowledge to the commercial sector. However, multiple barriers in TT can impede commercialization and innovative progress. To cultivate a deeper understanding, we conducted five interviews with strategic, elite leaders in different areas of TT in the United States. Experts shared their perspectives on the current state of TT, what needs improvement, and potential solutions to enhance the TT landscape, with a focus on biotechnology and medical devices. The formation of strong management teams, a comprehension of the regulatory, reimbursement, and funding pathways and policies, and thorough market assessments were noted as key aspects for venture success. Collaboration with Technology Transfer Offices (TTOs), industry experts, and strategic partners are also essential to support academic innovators and guide them throughout the complex commercialization process. There is agreement that a venture should have a defined vision and clear goals with a robust business case for the innovation; early involvement of TTOs is essential. Comprehension of the complexities and key facets of TT, while also streamlining the process, will better position biomedical innovators for success.
PMCID:11144850
PMID: 38832091
ISSN: 2504-0537
CID: 5665152
Longitudinal data support university-based biomedical entrepreneurship education programs
Vizgan, Gabriel; Hill-Whilton, Zachary; Achuonjei, Joy; Schweickart, Tucker; Chitale, Sadhana; Gillespie, Colleen; Gold-von Simson, Gabrielle
PMID: 36922690
ISSN: 1546-1696
CID: 5443502
The Biomedical Entrepreneurship Skills Development Program for the Advancement of Research Translation: Foundations of Biomedical Startups course, metrics, and impact
Schweickart, Tucker; Hill-Whilton, Zachary; Chitale, Sadhana; Cobos, Daniel; Gilon-Yanai, Michal; Achuonjei, Joy; Vizgan, Gabriel; Gillespie, Colleen; Gold-Von Simson, Gabrielle
Background/Objective: A growing number of biomedical doctoral graduates are entering the biotechnology and industry workforce, though most lack training in business practice. Entrepreneurs can benefit from venture creation and commercialization training that is largely absent from standard biomedical educational curricula. The NYU Biomedical Entrepreneurship Educational Program (BEEP) seeks to fill this training gap to prepare and motivate biomedical entrepreneurs to develop an entrepreneurial skill set, thus accelerating the pace of innovation in technology and business ventures. Methods: The NYU BEEP Model was developed and implemented with funding from NIDDK and NCATS. The program consists of a core introductory course, topic-based interdisciplinary workshops, venture challenges, on-line modules, and mentorship from experts. Here, we evaluate the efficacy of the core, introductory course, Foundations of Biomedical Startups, through the use of pre/post-course surveys and free-response answers. Results: After 2 years, 153 participants (26% doctoral students, 23% post-doctoral PhDs, 20% faculty, 16% research staff, 15% other) have completed the course. Evaluation data show self-assessed knowledge gain in all domains. The percentage of students rating themselves as either competent or on the way to being an expert in all areas was significantly higher post-course (P < 0.05). In each content area, the percentages of participants rating themselves as very interested increased post-course. 95% of those surveyed reported the course met its objectives, and 95% reported a higher likelihood of pursuing commercialization of discoveries post-course. Conclusion: NYU BEEP can serve as a model to develop similar curricula/programs to enhance entrepreneurial activity of early-stage researchers.
SCOPUS:85149914512
ISSN: 2059-8661
CID: 5446842
The development of a clinical research educational training for community health workers using the joint task force for clinical trial competency framework
Yakubov, Amin; Pimenova, Dina; Ahmed, Alzahraa; Corvacho, Romelia; Madigan, Joanna; Naik, Jay; Lyu, Chen; McFarlane, Anita; Foster, Victoria; Haseltine, Megan; Trifonov, Alexandr; Cabrera, Ivette; Rios, Clarissa; Gross, Rachel; Jay, Melanie; Lord, Aaron; Gold-von Simson, Gabrielle; Roy, Brita; Freeman, Amy; Islam, Nadia; Holahan, James
PMCID:10733486
PMID: 38130403
ISSN: 1663-9812
CID: 5612162
Dancing with uncertainties in the era of artificial intelligence [Editorial]
Ventura, Juan; Gold-von Simson, Gabrielle; Sukhov, Renat
In this commentary, a medical student reflects on the promise of artificial intelligence (AI) in mitigation of physician burnout and moral injury. The rapid introduction of AI technologies may present a challenge to medical professionals, especially those engaged in the transdisciplinary care of children with disabilities.
PMCID:10578284
PMID: 37718876
ISSN: 1875-8894
CID: 5602742
Integrating medicine, engineering and business to educate early-stage researchers in cardiovascular device development
Vizgan, Gabriel; Hill-Whilton, Zachary; Gillespie, Colleen; Cobos, Daniel; Johnson, LeAnn; Dib, Nabil; Gold-von Simson, Gabrielle
PMID: 36207597
ISSN: 1546-1696
CID: 5339902
Chronic Non-infectious Osteomyelitis Mimicking Scurvy as the Presenting Sign of Crohn's Disease: Case Report [Case Report]
Goldfarb, Alexa; Breitling, Stefan; Amadasun, Owen; Kiernan, Bridget; Gold-von Simson, Gabrielle; Sagalowsky, Selin T
Chronic non-infectious osteomyelitis (CNO) is a rare, inflammatory process associated with pediatric inflammatory bowel disease (IBD). Signs and symptoms of CNO parallel scurvy, a nutritional deficiency that can affect children with autism spectrum disorder (ASD). This is the first report of a child initially thought to have scurvy, then subsequently diagnosed with CNO as the presenting manifestation of Crohn's disease. This case enhances the literature elucidating extra-intestinal manifestations of IBD and pediatric nutritional deficiencies.
PMCID:9043343
PMID: 35498788
ISSN: 2296-2360
CID: 5203372