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A Theory-Based Educational Booklet Improves Colonoscopy Attendance and Bowel Preparation Quality [Meeting Abstract]

Gausman, Valerie; Quarta, Giulio; Lee, Michelle H.; Chtourmine, Natalia; Ganotisi, Carmelita; Nanton-Gonzalez, Frances; Ng, Chui Ling; Jun, Jungwon; Perez, Leslie; Sherman, Scott E.; Poles, Michael A.; Liang, Peter S.
ISI:000439259000296
ISSN: 0002-9270
CID: 3242512

Dysphagia Aortica, an Extrinsic Cause of Dysphagia

Quarta, Giulio; Poppers, David M.
The etiologies of dysphagia are myriad, including intrinsic disorders of the esophagus, such as neoplasia, stricture, severe reflux disease and motility disorders. Extrinsic etiologies of dysphagia include compression from adjacent lymph nodes or vascular structures. The importance of extrinsic compression is emphasized in this case of a patient presenting with the acute onset of dysphagia to solids, found to have compression of the esophagus secondary to a tortuous aorta. Despite a relatively normal endoscopic exam, this patient demonstrated significant pathology during follow up barium esophagram. Clinical signs and symptoms cannot reliably distinguish extrinsic from intrinsic causes of dysphagia and thus dysphagia aortica, which can be associated with imminent aneurysmal rupture, should be considered in elderly patients with acute onset dysphagia.
ISI:000410794800004
ISSN: 0277-4208
CID: 3242502

IMPROVED MORTALITY AND LENGTH OF STAY FOR PATIENTS WITH HEPATORENAL SYNDROME BETWEEN 2008 AND 2013: AN ANALYSIS OF THE NIS DATABASE [Meeting Abstract]

Kilaru, Saikiran M.; Quarta, Giulio; Popov, Violeta
ISI:000403140303646
ISSN: 0016-5085
CID: 4576432

DIABETES, HEART FAILURE, AND CHRONIC KIDNEY DISEASE ARE RISK FACTORS FOR NAFLD-RELATED CIRRHOSIS: A NATIONWIDE ANALYSIS [Meeting Abstract]

Kilaru, Saikiran M.; Quarta, Giulio; Popov, Violeta
ISI:000403140302621
ISSN: 0016-5085
CID: 4576412

Improvement in Adenoma Detection Rate in a High Risk Population Using Two Simple Interventions [Meeting Abstract]

Quarta, Giulio; Chua, Deborah; Srisarajivakul, Nalinee Caroline; Fradkov, Elena; Leigh, Lyvia; Ou, Amy; Poles, Michael A; Goodman, Adam; Williams, Renee
ISI:000395764600148
ISSN: 1572-0241
CID: 2492372

It's All in the History: Infectious Mimics of Inflammatory Bowel Disease [Meeting Abstract]

Quarta, Giulio; Lopatin, Sarah; Betesh, Andrea; Malter, Lisa; Gamagaris, Zoi
ISI:000395764603028
ISSN: 1572-0241
CID: 2492602

How We Cleaned It Up: A Simple Method That Improved Our Practice's Bowel Prep

Srisarajivakul, Nalinee; Chua, Deborah; Williams, Renee; Leigh, Lyvia; Ou, Amy; Quarta, Giulio; Poles, Michael A; Goodman, Adam
PMID: 27113117
ISSN: 1572-0241
CID: 2092402

Dynamic energy landscapes of riboswitches help interpret conformational rearrangements and function

Quarta, Giulio; Sin, Ken; Schlick, Tamar
Riboswitches are RNAs that modulate gene expression by ligand-induced conformational changes. However, the way in which sequence dictates alternative folding pathways of gene regulation remains unclear. In this study, we compute energy landscapes, which describe the accessible secondary structures for a range of sequence lengths, to analyze the transcriptional process as a given sequence elongates to full length. In line with experimental evidence, we find that most riboswitch landscapes can be characterized by three broad classes as a function of sequence length in terms of the distribution and barrier type of the conformational clusters: low-barrier landscape with an ensemble of different conformations in equilibrium before encountering a substrate; barrier-free landscape in which a direct, dominant "downhill" pathway to the minimum free energy structure is apparent; and a barrier-dominated landscape with two isolated conformational states, each associated with a different biological function. Sharing concepts with the "new view" of protein folding energy landscapes, we term the three sequence ranges above as the sensing, downhill folding, and functional windows, respectively. We find that these energy landscape patterns are conserved in various riboswitch classes, though the order of the windows may vary. In fact, the order of the three windows suggests either kinetic or thermodynamic control of ligand binding. These findings help understand riboswitch structure/function relationships and open new avenues to riboswitch design.
PMCID:3280964
PMID: 22359488
ISSN: 1553-734x
CID: 622262

The case for SmartTrack

Chapter by: Paik, Michael; Sharma, Ashlesh; Meacham, Arthur; Quarta, Giulio; Smith, Philip; Trahanas, John; Levine, Brian; Hopkins, Mary Ann; Rapchak, Barbara; Subramanian, Lakshminarayanan
in: 2009 International Conference on Information and Communication Technologies and Development, ICTD 2009 - Proceedings by
[S.l.] : Institute of Electrical and Electronics Engineers Inc., 2009
pp. 458-467
ISBN: 9781424446636
CID: 2874362

Estimating the fraction of non-coding RNAs in mammalian transcriptomes

Xin, Yurong; Quarta, Giulio; Gan, Hin Hark; Schlick, Tamar
Recent studies of mammalian transcriptomes have identified numerous RNA transcripts that do not code for proteins; their identity, however, is largely unknown. Here we explore an approach based on sequence randomness patterns to discern different RNA classes. The relative z-score we use helps identify the known ncRNA class from the genome, intergene and intron classes. This leads us to a fractional ncRNA measure of putative ncRNA datasets which we model as a mixture of genuine ncRNAs and other transcripts derived from genomic, intergenic and intronic sequences. We use this model to analyze six representative datasets identified by the FANTOM3 project and two computational approaches based on comparative analysis (RNAz and EvoFold). Our analysis suggests fewer ncRNAs than estimated by DNA sequencing and comparative analysis, but the verity of our approach and its prediction requires more extensive experimental RNA data
PMCID:2735967
PMID: 19812767
ISSN: 1177-9322
CID: 143526