Faculty Bibliography

BRAF inhibitor-induced neutrophilic panniculitis is a rare event that is well-characterized in adults undergoing therapy for metastatic melanoma. To date, there are very few reports of this event in children undergoing BRAF inhibitor therapy for low-grade gliomas, all of which were seen with vemurafenib. We report a case of dabrafenib-induced neutrophilic panniculitis in a 9-year-old girl that manifested within several weeks of initiating dual BRAF-MEK inhibitor therapy for glioblastoma multiforme. This case highlights neutrophilic panniculitis as a side effect of dabrafenib in children and serves as a reminder to consider cutaneous side effects of BRAF inhibitors as they are increasingly used to treat children with primary brain tumors.

There are a number of dermatoses that manifest in the genital region. Urologists are often the first point of contact for patients with such disorders. These can be isolated genital conditions or manifestations of a more widespread cutaneous disease. Though similar appearing, there are often key clinical findings that aid in in diagnosis. In general, genital dermatoses can be classified as physiologic variants, inflammatory, neoplastic, or infectious in etiology. This article provides a broad overview for urologists in addressing both common and rarer penile and scrotal dermatoses. Emphasis is placed on characteristic clinical findings to aid in diagnosis. Recommendations for diagnostic evaluation, treatment, and appropriate follow-up are discussed.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY.

Infectious panniculitis from hematogenous spread is uncommon and usually occurs in immunocompromised patients. Dissemination of gram-positive organisms to the subcutaneous tissue is rare with only several reports of disseminated panniculitis caused by Streptococcal species. We report a case of an immunocompetent 2-year-old boy presenting with diffuse neutrophilic panniculitis arising from methicillin-resistant Staphylococcus aureus septicemia. This case represents a highly atypical manifestation of severe MRSA infection and serves as a reminder to consider MRSA as a cause of disseminated neutrophilic panniculitis, particularly in high-risk populations.

Frontal fibrosing alopecia (FFA) represents an uncommon variant of lichen planopilaris (LPP). While the histopathology of both conditions is similar, their clinical presentations are distinct. FFA exhibits progressive recession of frontal and temporoparietal hairlines, and involvement of eyebrows, beard, and body hair with loss of follicular ostia. FFA in males represents a rare subset of cases, yet reported cases are increasing. This population necessitates further evaluation to define demographics, clinical presentation, diagnostic pearls, and effective therapies.