Faculty Bibliography

Pyogenic liver abscess (PLA) is known as a pus-filled lesion found in the liver which can quickly become fatal if not found and treated in a timely manner. The most common group of bacteria found in PLA is the Streptococcus Anginosus Group (SAG). Patients with PLA usually present with fever and right upper quadrant abdominal pain which can at times be referred to the right shoulder owing to dermatomal involvement. We present a case where a patient with a past medical history significant for recent diverticulosis presenting with a left lower quadrant abdominal pain, fever, and hypotension and on further workup was found to have a PLA. Blood cultures and cultures from the abscess grew Streptococcus constellatus. This bacteria is part of the SAG group however, it is rarely found in PLA and bloodstream.

Intrauterine devices (IUDs) are a form of long-acting reversible contraception (LARC). As with all medical therapies, their use carries several risks and potential adverse effects. For patients who elect to continue IUD use, pain and irregular bleeding are the most commonly reported complications, but more serious and less common complications include expulsion, contraception failure, pelvic inflammatory disease (PID), and perforation. We report a case where a patient with a history of IUD placement in the immediate postpartum period developed significant complications including multiple intra-abdominal abscesses and pelvic inflammatory disease.

An aortic dissection is a life-threatening event that requires urgent evaluation. A dissection is defined as a tear in the innermost layer of the aortic wall forming a true and false lumen. This is normally diagnosed with a CT with contrast when clinical suspicion is present. Deciding whether urgent surgical intervention is required is key, as it may determine the survival of the patient. The treatment of type A aortic dissection involves emergent open-heart surgery. Medical treatment and clinical follow-up are recommended for uncomplicated type B dissections. In this report, we present a case of an extensive type B aortic dissection in an asymptomatic patient who required immediate surgical intervention.

Resveratrol, a natural polyphenol produced by plants in response to environmental stress, has received great attention during the past few years due to its beneficial roles in longevity and glucose homeostasis. Resveratrol has been found to display antioxidant, anti-inflammatory, antifibrotic, and cardioprotective properties. Resveratrol reduces platelet aggregation, induces vasorelaxation, limits endothelial activation, and modulates lipid and lipoprotein metabolism. Although the mechanisms of action of resveratrol have not been completely defined, there is evidence that some of the effects of resveratrol may be mediated via activation of sirtuin 1 and AMP-activated protein kinase and through inhibition of the pleiotropic transcription factor nuclear factor kappaB. Pathways proposed to underlie resveratrol-mediated cardioprotection include reduction of oxidative stress and activation of endothelial nitric oxide synthase. Adenosinergic mechanisms may play a role in its atheroprotective activity. The ability of the nutraceutical resveratrol to positively influence the future treatment of cardiovascular disease is discussed.