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Accuracy of Ultrasound Compared to Magnetic Resonance Imaging in the Diagnosis of Thumb Ulnar Collateral Ligament Injuries: A Prospective Case Series

Moore, Brittany J; Iafrate, Julia L; Kakar, Sanjeev; Wisniewski, Stephen J; Murthy, Naveen S; Smith, Jay
This prospective case series compared the accuracy of ultrasound (US) to magnetic resonance imaging (MRI) in differentiating complete displaced (CD) thumb ulnar collateral ligament (UCL) tears from nondisplaced injuries in 10 patients with suspected traumatic thumb UCL injuries. Ultrasound identified 100% (2 of 2) of MRI-documented CD tears, both of which were further confirmed during surgical repair. Ultrasound identified the absence of CD tears in the remaining 8 patients. Although MRI is the reference standard imaging modality for characterizing thumb UCL injuries, ultrasound should be considered an accurate, cost-effective, and alternative imaging modality to differentiate surgical versus nonsurgical thumb UCL injuries.
PMID: 32930402
ISSN: 1550-9613
CID: 5004672

Diagnosis and Management of Foot and Ankle Injuries in Dancers

Iafrate, Julia L.; Townsend, Christine E.; Scott, Charles; Yun, Hye-Jin; Ventola, Allison; Semanson, Suzanne
ISSN: 2167-4833
CID: 5071062

Cellular neuroinflammation in a lateral forceps compression model of spinal cord injury

Vaughn, Chloe N; Iafrate, Julia L; Henley, Jessica B; Stevenson, Edward K; Shlifer, Igor G; Jones, T Bucky
Postinjury inflammation has been implicated in secondary degeneration following injury to the spinal cord. The cellular inflammatory response to injury has not been described in the lateral compression injury model, although various types of compression injuries account for ∼20% of human spinal cord injuries (SCI). Here, we used forceps to induce a moderate compression injury to the thoracic spinal cord of female Sprague-Dawley rats. We evaluated innate and adaptive components of the inflammatory response at various times postinjury using immunohistochemical techniques. We show that components of innate immunity (e.g., macrophages and dendritic cells) peak between 1 and 2 weeks postinjury but persist through 42 days postinjury (dpi). CD163 and CD206 expression, associated with an anti-inflammatory, reparative phenotype, was upregulated on activated macrophages in the injury site, as were MHC class II antigens. The expression of MHC class II antigens is necessary for the initiation of adaptive immunity and was accompanied by an influx of T cells. T cells were initially restricted to gray matter at the injury epicenter but were later observed throughout the lesioned parenchyma. In summary, we demonstrate that lateral forceps compression of the spinal cord produces a neuroinflammatory response similar to that described in human spinal cord trauma and in other experimental models of spinal cord trauma, thus is an appropriate model to study secondary neurodegeneration in SCI.
PMID: 23775900
ISSN: 1932-8494
CID: 5004662

Neuroinflammation in a Forceps Compression Model of Spinal Cord Injury [Meeting Abstract]

Vaughn, Chloe N.; Henley, Jessica B.; Iafrate, Julia; Stevenson, Edward; Jones, T. Bucky
ISSN: 0892-6638
CID: 5071072