Try a new search

Format these results:

Searched for:

person:jegedk01

in-biosketch:true

Total Results:

12


Quantifying the variability of financial disclosure information reported by authors presenting research at multiple sports medicine conferences

Jegede, Kolawole A; Ju, Brian; Miller, Christopher P; Whang, Peter; Grauer, Jonathan N
In the study reported here, we compared self-reported industry relationships of authors who attended 3 major orthopedic sports medicine conferences during a single calendar year. Our goal was to calculate the variability between disclosure information over time. A significant percentage of authors who attended these meetings were inconsistent in submitting their disclosure information. In addition, most authors with irregularities had more than 1 discrepancy. We believe that the vast majority of the observed discrepancies did not result from intentional deception on the part of the authors but instead from ongoing confusion regarding which industry relationships should be acknowledged for particular meetings (some specialty societies require that all relationships be divulged, whereas others require only those affiliations directly applicable to research being presented). In the absence of a uniform disclosure policy that is widely adopted by many specialty societies, these findings suggest that the disclosure process will continue to be plagued by inconsistent reporting of financial conflicts of interest.
PMID: 22263213
ISSN: 1934-3418
CID: 2675842

Substantial variation in the interpretation of financial disclosure policies for orthopaedic society meetings

Jegede, Kolawole; Whang, Peter; Grauer, Jonathan N
BACKGROUND: Physician disclosure of potential conflicts of interest is currently controversial. To address this issue, orthopaedic societies have implemented a variety of guidelines related to potential conflict-of-interest disclosure. Transparency is crucial to address the concerns about potential conflict-of-interest disclosure. Nonetheless, prior studies have noted substantial discrepancies in disclosures to societies for individual authors who present their research work at multiple conferences. Our goal was to evaluate the ability of orthopaedic surgeons to interpret disclosure policy statements regarding project-specific or global disclosure instructions. METHODS: The disclosure policy statements of the ten conferences most frequently attended by this group were collected, and selected statements were compiled into a questionnaire survey that was administered to orthopaedic faculty and trainees at our institution. Subjects were asked to read each statement and identify whether they interpreted the policy to be requesting project-specific disclosures (potential conflict of interest related to the research work in the abstract being submitted) or global disclosure (inclusive of all potential conflicts of interest, including those not associated with the abstract being submitted). The correct responses were identified by communicating with the individual societies and determining the responses desired by the society. RESULTS: The study had a 100% return rate from seventeen orthopaedic faculty, twenty-five orthopaedic residents and fellows, and twenty-five medical students. The average number of incorrect responses to the ten questions was 2.8. Forty-six percent of respondents had three or more incorrect responses, 24% had two incorrect responses, 19% had one incorrect response, and 10% had no incorrect responses. There was no significant difference in responses between those of different training levels. Subjects were no more likely to answer a project-specific question incorrectly than they were to answer a global question incorrectly. CONCLUSIONS: This study clearly demonstrated a discrepancy between what societies intend to identify with disclosure policies and what the orthopaedist interprets is intended. Almost half of those completing the survey did not correctly understand the intention of three or more of the policies, even with expected study intent bias. This study showed that the language used in disclosure policy statements and the lack of a uniform policy may be a cause of substantial discrepancies in potential conflict-of-interest disclosure.
PMID: 21776560
ISSN: 1535-1386
CID: 2675832

Contemporary management of symptomatic lumbar disc herniations

Jegede, Kolawole A; Ndu, Anthony; Grauer, Jonathan N
Lumbar disc herniations are common clinical entities that may cause lumbar-related symptoms. The spectrum of treatment options is geared toward a patient's clinical presentation and ranges from nothing to surgical intervention. Many lumbar disc herniations cause no significant symptoms. In studies of asymptomatic individuals who have never experienced lumbar-related symptoms, 30% have been reported to have major abnormality on magnetic resonance imaging. The mainstay of treatment of patients with symptomatic disc herniations is accepted to be nonoperative (as long as there are no acute or progressive neurologic deficits); this includes medications, physical therapy, and potentially lumbar injection. For patients with symptomatic disc herniations who fail to respond appropriately to conservative measures, surgical intervention may be considered. For this population, lumbar discectomy is considered to be a good option.
PMID: 20399360
ISSN: 1558-1373
CID: 2209262

No Clear Benefit of Chlorhexidine Use at Home Before Surgical Preparation

Makhni, Melvin Chugh; Jegede, Kolawole; Lombardi, Joseph; Whittier, Susan; Gorroochurn, Prakash; Lehman, Ronald A; Riew, K Daniel
INTRODUCTION/BACKGROUND:Several studies have evaluated the efficacy of home use of chlorhexidine before surgery to reduce bacterial colonization. However, these studies have provided conflicting evidence about the potential efficacy of this strategy in decreasing bacterial loads and infection rates across surgical populations, and no prior study has analyzed the benefit of this intervention before spine surgery. We prospectively analyzed the effectiveness of chlorhexidine gluconate wipes for decreasing bacterial counts on the posterior neck. METHODS:Sixteen healthy adults participated in this prospective study. The right side of each participant's neck was wiped twice (the night before and the morning of the experiment) with chlorhexidine gluconate wipes. The left side was used as the control region. Bacterial swabs were obtained as a baseline upon enrollment in the study, then upon arrival at the hospital, and, finally, after both sides of the neck had received standard preoperative scrubbing. RESULTS:All patients had positive baseline bacterial growth (median >1,000 colonies/mL). When chlorhexidine gluconate wipes were used, decreased bacterial counts were noted before the preoperative scrub, but this finding was not statistically significant (P = 0.059). All patients had zero bacteria identified on either side of their neck after completion of the preoperative scrub. CONCLUSION/CONCLUSIONS:At-home use of chlorhexidine gluconate wipes did not decrease the topical bacterial burden. Therefore, using chlorhexidine gluconate wipes at home before surgery may offer no added benefit.
PMCID:5768234
PMID: 29227322
ISSN: 1940-5480
CID: 2905942

Pediatric elbow injuries in athletes

Makhni, Eric C; Jegede, Kola A; Ahmad, Christopher S
Elbow injuries in pediatric and adolescent population represent a spectrum of pathology that can range from medial tension injuries to posterior shear injuries. Elbow injuries in this population continue to rise in parallel with the increase in youth participation in sports both throughout the calendar year and across multiple sports. Many of these injuries are noncontact and are attributed to overuse. Evaluation and management of youth and adolescent athletic elbow injuries requires knowledge of developmental anatomy, injury pathophysiology, and established treatment algorithms. Furthermore, risk factors contributing to elbow injuries must be recognized, with education and recommendations for safe play continually advocated. This education--of parents, athletes, and coaches--is paramount in reducing the climbing incidence of elbow injuries in our youth athletes.
PMID: 25077752
ISSN: 1538-1951
CID: 2675872

Optimal aspiration volume of vertebral bone marrow for use in spinal fusion

Hustedt, Joshua W; Jegede, Kola A; Badrinath, Raghav; Bohl, Daniel D; Blizzard, Daniel J; Grauer, Jonathan N
BACKGROUND CONTEXT: Bone marrow aspirate (BMA) has shown promise as a bone graft option in spinal fusion. The vertebral body is a convenient source for marrow aspirate as it is accessed in routine course of pedicle screw instrumentation. Studies have relied on data from the iliac crest to determine optimal aspiration volume from the vertebral body. PURPOSE: This study is designed to determine the optimal aspiration volume for BMA taken from the vertebral body. STUDY DESIGN: Prospective clinical study. PATIENT SAMPLE: Data are drawn from 18 pedicles and 180 aspirations. The average age of the subjects was 50.3 years, and the subject pool comprised five men and seven women. OUTCOME MEASURES: Nucleated cell count and alkaline phosphatase staining colony forming units. METHODS: Ten 1 mL aliquots of BMA were incrementally aspirated through a cannulated pedicle tap for each instrumented vertebral body. The numbers of nucleated cells per mL of BMA were analyzed with a hemocytometer, and the percentage of osteoprogenitor cells per mL aspirate were estimated by an alk phos production assay. The study was funded through departmental funds, and none of the authors have any conflicts of interest to report related to the study. RESULTS: Nucleated cell count decreased with increasing aspirate number (p<.001). The average cell count for the first mL was 45.8 million cells. Cell counts did not differ by age or sex (p=.943 and p=.685, respectively). Likewise, osteoprogenitor cell percentage decreased with increasing aspirate number (p<.001). CONCLUSIONS: The 2 mL aspirate volume has been defined as ideal for the iliac crest, but there has been no analogous assessment of the effect of aspiration volume for other sources such as the vertebral body. This information is important for the clinical implementation of vertebral body aspirations if volume, cells, and presumably performance, of this potential bone graft option are to be optimized for spine cases. Our data show a direct relationship between increasing aspiration number and decreasing osteoprogenitor cellular concentration, with a drop to 50% of the original aspirate cell count by the 4th mL aspirate. The vertebral body is a potentially exciting source of osteoprogenitor cells that can be implemented for a variety of spinal uses.
PMID: 24075028
ISSN: 1878-1632
CID: 2675862

Biomechanical comparison of endplate forces generated by uniaxial screws and monoaxial pedicle screws

Essig, David A; Miller, Christopher P; Xiao, Ming; Ivancic, Paul; Jegede, Kola; Badrinath, Raghav; Smith, Brian G; Grauer, Jonathan N
Current surgical treatment of idiopathic scoliosis involves the use of various segmental instrumentation. Various pedicle screws have allowed for improved correction. Although monoaxial screws have improved rotational control compared with polyaxial screws, their use may increase screw-bone interface or vertebral endplate forces if not inserted in an exactly straight trajectory. Uniaxial screws potentially decrease these forces while retaining the advantages of monoaxial screws with respect to better rotational control. The purpose of this study was to compare the vertebral endplate forces with monoaxial or uniaxial screws when being reduced to a rod. Thirty-two plastic, surrogate T11 vertebrae were prepared with monoaxial (n=16) or uniaxial (n=16) screws. Screw angles relative to inferior vertebral endplates were assessed with lateral radiographs. The vertebrae were fixed to a load cell, and loads were measured as the screw was reduced to a rod. Monoaxial screws demonstrated a linear progression of endplate force with increasing screw angle. Uniaxial screws demonstrated minimal endplate force until approximately 20 degrees , coinciding with screwhead excursion angle. As this maximum excursion angle was passed, uniaxial screws demonstrated a force slope similar to the monoaxial screws.The measured endplate forces should be equivalent to forces at the screw-bone interface. The reduced force with uniaxial screws is expected to have less cranial-caudal plow potential as the screw is coupled to a rod for deformity correction. This could have potential implications for screw failure, especially in less dense bone.
PMID: 23027492
ISSN: 1938-2367
CID: 2675852

Recovery room radiographs after total hip arthroplasty: tradition vs utility?

Ndu, Anthony; Jegede, Kolawole; Bohl, Daniel D; Keggi, Kristaps; Grauer, Jonathan N
Routine inpatient radiographs after total hip arthroplasty can be taken in the recovery room immediately after surgery or in the radiology suite later in the hospital stay. In a review of 632 consecutive recovery room series, we found that 17% of series were inadequate to detect technical issues. We identified technical issues on 12 series (1.9%) and technical issues that impacted inpatient management on 2 series (0.3%). One of these 2 was a dislocation that was detected clinically before imaging. The other was a medial penetration of an acetabular screw that probably did not require the immediate revision that it received. Findings suggest that the single routine inpatient series should be taken in the radiology suite, rather than in the recovery room.
PMID: 22305435
ISSN: 1532-8406
CID: 2209292

The efficacies of 2 ceramic bone graft extenders for promoting spinal fusion in a rabbit bone paucity model

Miller, Christopher P; Jegede, Kolawole; Essig, David; Garg, Hitesh; Bible, Jesse E; Biswas, Debdut; Whang, Peter G; Grauer, Jonathan N
STUDY DESIGN: Prospective, randomized, controlled animal study. OBJECTIVE: To determine the efficacies of 2 ceramic composite bone graft extenders for promoting spinal fusion. SUMMARY OF BACKGROUND DATA: Although autogenous bone is still considered the "gold standard" graft material for fusion procedures, its use is associated with a number of limitations. Synthetic ceramic composites represent a class of osteoconductive materials that may be employed as supplements or even alternatives to autograft. In this study, we compared the fusion rates generated by 2 ceramic composite bone graft extenders (MasterGraft and Mozaik Strips) with that obtained with autograft in a rabbit bone paucity model. METHODS: Thirty-two New Zealand white rabbits undergoing noninstrumented posterolateral lumbar fusion were randomized to 1 of the following 4 groups: 100% autograft, 50% autograft, 50% autograft with Mozaik Strip, and 50% autograft with MasterGraft Strip. The rabbits were followed postoperatively for 8 weeks at which time the spinal segments were explanted and assessed for the presence of a solid fusion. RESULTS: The arthrodesis rates by manual palpation of the 100% and 50% autograft controls were 75% (6 of 8 animals) and 12.5% (1 of 8), respectively (P < 0.01). In the 50% autograft/Mozaik and 50% autograft/MasterGraft groups, 3/8 and 1/8 of the rabbits were determined to have fused successfully, respectively (P = 0.569). However, there were no significant differences between the fusion rate of the 50% autograft cohort and those exhibited by the Mozaik or MasterGraft animals (P = 0.569 and 1.00, respectively). CONCLUSION: This study provides further evidence that the quantity of autograft may influence the process of spinal fusion such that the arthrodesis rate was significantly lower when less bone was implanted. Neither of the ceramic composite scaffolds seemed to enhance the fusion response compared to an equivalent amount of autograft alone, suggesting that these substances may need to be combined with other osteogenic materials to optimize bone production.
PMID: 21857402
ISSN: 1528-1159
CID: 2209282

The effects of three different types of orthoses on the range of motion of the lumbar spine during 15 activities of daily living

Jegede, Kolawole A; Miller, Christopher P; Bible, Jesse E; Whang, Peter G; Grauer, Jonathan N
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To quantify which 3 common lumbar orthoses of varying rigidity restrict both full, active range of motion (ROM) and functional ROM required for activities of daily living (ADL). SUMMARY OF BACKGROUND DATA: Spinal orthoses are implemented to restrict lumbar motion. Despite widespread prevalence of lumbar bracing, the efficacy of these appliances for immobilizing the spine has not been definitively established. METHODS: The full, active ROM of 10 asymptomatic individuals was quantified using an electrogoniometer that registered maximum rotation in all planes. Subjects subsequently completed 15 simulated ADLs during which time their functional ROM was measured; performed without a brace and while wearing a corset, semirigid lumbosacral orthosis (LSO), and rigid custom-molded LSO. RESULTS: For flexion/extension, the mean percentage decreases (with SDs) in full, active ROM that were recorded with corset, semirigid, and a custom orthosis were 24.1 +/- 7.9%, 46.8 +/- 7.1%, and 64.7 +/- 8%, respectively (P < 0.001 relative to no brace). In the coronal plane, motion was restricted by 33.9 +/- 8.8%, 51.9 +/- 9.4%, and 49.1 +/- 11.8%, respectively (P < 0.001). Finally, rotation was limited by 39.6 +/- 8.8%, 59.2 +/- 10.2%, and 70.6 +/- 5.4%, respectively (P < 0.001). There were no significant discrepancies between the ROM recorded in the semirigid and custom LSOs for the ADLs. Likewise, functional ROM associated with corset and semirigid LSOs were only different for 2 ADLs whereas significant disparities between values with corset and custom LSOs were observed for 4 simulations. CONCLUSION: The full, active ROM allowed by lumbar braces evaluated was greater than employed during ADLs in absence of any brace. The motion decrease beyond actual restriction of the braces suggests they will act primarily as proprioceptive guides to regulate movement.
PMID: 21358469
ISSN: 1528-1159
CID: 2209272