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Myocardial Injury in Adults Hospitalized with COVID-19 [Letter]

Smilowitz, Nathaniel R; Jethani, Neil; Chen, Ji; Aphinyanaphongs, Yindalon; Zhang, Ruina; Dogra, Siddhant; Alviar, Carlos L; Keller, Norma Mary; Razzouk, Louai; Quinones-Camacho, Adriana; Jung, Albert S; Fishman, Glenn I; Hochman, Judith S; Berger, Jeffrey S
PMID: 33151762
ISSN: 1524-4539
CID: 4664312

A case of nonvalvular endocarditis with biventricular apical infected thrombi [Case Report]

Vani, Anish; Ahluwalia, Monica; Donnino, Robert; Jung, Albert; Vaynblat, Mikhail; Latson, Larry; Saric, Muhamed
We report what appears to be the first case of biopsy-proven nonvalvular endocarditis with biventricular apical infected thrombi. A 47-year-old man presented with hypoxic respiratory failure from a multilobar pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). Transthoracic echocardiography and cardiac magnetic resonance imaging revealed biventricular apical masses suggestive of nonvalvular endocarditis with infected thrombi. Given concern for ongoing septic embolization to the lungs and brain despite appropriate antimicrobial therapy, the masses were surgically resected. Culture and histopathology confirmed MRSA-positive infected thrombi. In this case report, we highlight the differential diagnosis of apical masses and the role of multimodality imaging.
PMID: 32654168
ISSN: 1540-8175
CID: 4527722

Radiation-Induced Left Main Coronary Artery Stenosis in a Patient with Atretic Internal Mammary Arteries [Case Report]

Dogra, Siddhant; Mahajan, Asha M; Jung, Albert; Attubato, Michael; Saric, Muhamed; Shah, Alan
Coronary artery disease (CAD) is a known potential complication of thoracic radiation treatment that typically affects the proximal segments of the coronary arteries, requiring coronary artery bypass grafting (CABG). We present a case of acute coronary syndrome occurring in a 57-year-old man with prior thoracic radiation therapy following resection of a chest wall chondrosarcoma. Coronary angiogram demonstrated significant areas of stenosis in the left main coronary artery (LMCA) and ostial left anterior descending (LAD) coronary artery. The patient was also found to have atretic bilateral internal mammary arteries as a consequence of his radiation therapy, rendering them unsuitable as grafts. Percutaneous coronary intervention (PCI) was thus performed with a successful outcome. To our knowledge, this is the first case of radiation-induced CAD of the LMCA with atretic internal mammary arteries treated successfully with PCI.
PMID: 32455030
ISSN: 2090-6404
CID: 4451702

The Tale of Two Chambers : Late Diagnosis of a Young Condition [Meeting Abstract]

Dwivedi, Aeshita; Weinberg, Catherine; Jung, Albert
ISSN: 0009-7322
CID: 3130092

Complete Resolution of Tumor Burden of Primary Cardiac Non-Hodgkin's Lymphoma

Mauricio, Rina; Mgbako, Ofole; Buntaine, Adam; Moreira, Andre; Jung, Albert
Primary cardiac tumors are a rare set of benign and malignant neoplasms found in the heart or pericardium. We describe a patient presenting with nonspecific symptoms and ultimately diagnosed with primary cardiac non-Hodgkin's lymphoma (PCL). Our patient had extensive tumor in the right ventricle, which extended into the right atrium and right ventricular outflow tract. The tumor also encased the right coronary artery, which manifested as ischemic changes on EKG and cardiac MRI. The patient was treated with chemotherapy and achieved complete remission, with dramatic and full resolution of the mass on repeat echocardiography in nine weeks. More studies are needed to understand the optimal management and prognosis of patients with PCL.
PMID: 28101382
ISSN: 2090-6404
CID: 2413032

Mast cells: a pivotal role in pulmonary fibrosis

Veerappan, Arul; O'Connor, Nathan J; Brazin, Jacqueline; Reid, Alicia C; Jung, Albert; McGee, David; Summers, Barbara; Branch-Elliman, Dascher; Stiles, Brendon; Worgall, Stefan; Kaner, Robert J; Silver, Randi B
Pulmonary fibrosis is characterized by an inflammatory response that includes macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study was to evaluate whether mast cells play a role in initiating pulmonary fibrosis. Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient WBB6F1-W/W(v) (MCD) mice and their congenic controls (WBB6F1-(+)/(+)). Mast cell deficiency protected against bleomycin-induced pulmonary fibrosis, but protection was reversed with the re-introduction of mast cells to the lungs of MCD mice. Two mast cell mediators were identified as fibrogenic: histamine and renin, via angiotensin (ANG II). Both human and rat lung fibroblasts express the histamine H1 and ANG II AT1 receptor subtypes and when activated, they promote proliferation, transforming growth factor β1 secretion, and collagen synthesis. Mast cells appear to be critical to pulmonary fibrosis. Therapeutic blockade of mast cell degranulation and/or histamine and ANG II receptors should attenuate pulmonary fibrosis.
PMID: 23570576
ISSN: 1557-7430
CID: 3239642

Mast Cell and Fibroblast Infiltration in Laser-Induced Choroidal Neovascularization [Meeting Abstract]

Skondra, D.; O'Connor, N. J.; Jung, A.; Veerappan, A.; Rosenblatt, M. I.; D'Amico, D. J.; Silver, R. B.
ISSN: 0146-0404
CID: 3726482


Veerappan, A.; O'Connor, N.; Jung, A.; Brazin, J.; Reid, A. C.; Kaner, R. J.; Silver, R. B.
ISSN: 1073-449x
CID: 3242722

Effect of mast cell mediators on fibroblast activation: Role in renal fibrosis [Meeting Abstract]

Silver, RB; Veerappan, Arul; Jung, A; Janssen, R; Felsen, D; Chen, J; Rhoades, DP
ISSN: 1533-3450
CID: 3696752

Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium

Jung, Albert S; Kubo, Hajime; Wilson, Rachel; Houser, Steven R; Margulies, Kenneth B
L-Arginine, the sole substrate for the nitric oxide (NO) synthase (NOS) enzyme in producing NO, is also a substrate for arginase. We examined normal feline hearts and hearts with compensated left ventricular (LV) hypertrophy (LVH) produced by ascending aorta banding. Using Western blot analysis, we examined the abundance of arginase isozymes in crude homogenates and isolated cardiac myocytes obtained from the LVs of normal and LVH hearts. We examined the functional significance of myocyte arginase via measurement of shortening and intracellular calcium in isolated myocytes in the presence and absence of boronoethyl chloride (BEC), a specific pharmacological inhibitor of arginase. Both arginase I and II were detected in crude myocardial homogenates, but only arginase I was present in isolated cardiac myocytes. Arginase I was downregulated in LVH compared with normal. Inhibition of arginase with BEC reduced fractional shortening, maximal rate of shortening (+dL/dt) and relengthening (-dL/dt), and the peak of the free cytosolic calcium transient in normal myocytes but did not affect these parameters in LVH myocytes. These negative inotropic actions of arginase inhibition were associated with increases in cGMP generation. These studies indicate that only arginase I is present in cardiac myocytes where it tends to limit NO and cGMP production with the effect of supporting basal contractility. In experimental LVH induced by pressure overload, our studies demonstrate reduced arginase I expression and reduced functional significance, allowing greater arginine substrate availability for NO/cGMP signaling.
PMID: 16327014
ISSN: 0363-6135
CID: 1072112