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A Woman With Painful Digital Ulcers

Karagounis, Theodora; Belmont, H Michael; Caplan, Avrom S
PMID: 35344026
ISSN: 1538-3598
CID: 5200912

Chronic tongue pain and alopecia

Karagounis, Theodora; Yan, Di; Oza, Vikash; Kim, Randie
PMID: 34931369
ISSN: 1525-1470
CID: 5108762

Response to "Patient preference for cellulitis treatment: at-home care is preferred to hospital-based treatment" [Letter]

Shaw, Katharina S; Karagounis, Theodora K; Yin, Lu; Gibbon, Grace; Betensky, Rebecca A; Lo Sicco, Kristen I; Femia, Alisa N
PMCID:7413198
PMID: 32777319
ISSN: 1097-6787
CID: 4556092

Viral Venereal Diseases of the Skin

Karagounis, Theodora K; Pomeranz, Miriam K
Viral venereal diseases remain difficult to treat. Human papilloma virus (HPV) and herpes simplex virus (HSV) are two common viral venereal diseases. HPV infections are characterized by anogenital warts and less commonly by premalignant or malignant lesions. HSV infections classically present as grouped vesicles on an erythematous base with associated burning or pain; however, immunosuppressed patients may have atypical presentations with nodular or ulcerative lesions. This review discusses the epidemiology, diagnosis, and management of anogenital HPV and HSV infections with an emphasis on treatment modalities for the practicing dermatologist. Diagnosis of these diseases typically relies on clinical assessment, although multiple diagnostic techniques can be utilized and are recommended when diagnosis is uncertain or evaluating an individual with increased risk of malignancy. Management of HPV and HSV infections involves appropriate counseling, screening, and multiple treatment techniques. Particularly for HPV infections, a practitioner may need to use a combination of techniques to achieve the desired outcome.
PMID: 34008162
ISSN: 1179-1888
CID: 4878702

Acrofacial purpura and necrotic ulcerations in COVID-19: a case series from New York City

Karagounis, Theodora K; Shaw, Katharina S; Caplan, Avrom; Lo Sicco, Kristen; Femia, Alisa N
PMID: 32966592
ISSN: 1365-4632
CID: 4615722

Exchanging Dermatoscopes for Stethoscopes: Has the COVID-19 Pandemic Highlighted Gaps in US Dermatology Residency Training?

Shaw, Katharina S; Karagounis, Theodora K; Yin, Lu; Svigos, Katerina; Gibbon, Grace T; Betensky, Rebecca A; Lo Sicco, Kristen I
PMID: 33026742
ISSN: 1545-9616
CID: 4626932

Recurrent spontaneous pneumothoraces and vaping in an 18-year-old man: a case report and review of the literature [Case Report]

Bonilla, Alex; Blair, Alexander J; Alamro, Suliman M; Ward, Rebecca A; Feldman, Michael B; Dutko, Richard A; Karagounis, Theodora K; Johnson, Adam L; Folch, Erik E; Vyas, Jatin M
BACKGROUND:Primary spontaneous pneumothorax is a common disorder occurring in young adults without underlying lung disease. Although tobacco smoking is a well-documented risk factor for spontaneous pneumothorax, an association between electronic cigarette use (that is, vaping) and spontaneous pneumothorax has not been noted. We report a case of spontaneous pneumothoraces correlated with vaping. CASE PRESENTATION/METHODS:An 18-year-old Caucasian man presented twice with recurrent right-sided spontaneous pneumothoraces within 2 weeks. He reported a history of vaping just prior to both episodes. Diagnostic testing was notable for a right-sided spontaneous pneumothorax on chest X-ray and computed tomography scan. His symptoms improved following insertion of a chest tube and drainage of air on each occasion. In the 2-week follow-up visit for the recurrent episode, he was asymptomatic and reported that he was no longer using electronic cigarettes. CONCLUSIONS:Providers and patients should be aware of the potential risk of spontaneous pneumothorax associated with electronic cigarettes.
PMCID:6732835
PMID: 31495337
ISSN: 1752-1947
CID: 5181772

Painless nodule on the leg [Case Report]

Karagounis, Theodora K; Rotemberg, Veronica
PMID: 31348456
ISSN: 2326-6929
CID: 5221242

Use of "natural" oils for moisturization: Review of olive, coconut, and sunflower seed oil

Karagounis, Theodora K; Gittler, Julia K; Rotemberg, Veronica; Morel, Kimberly D
Despite the availability of effective medications for the management of atopic dermatitis and xerosis, patients may use nonconventional therapies such as topical oils. Patients choose these treatments because of the perceived lower risk of natural products and the fear of potential adverse effects of topical steroids. We review the use of topical olive, coconut, and sunflower seed oil in the treatment of atopic dermatitis and xerosis with a focus on children Currently available evidence suggests that olive oil may exacerbate xerosis and atopic dermatitis. Further studies are needed to make definitive recommendations regarding the use of coconut and sunflower seed oil.
PMID: 30152555
ISSN: 1525-1470
CID: 5221232

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Bar-On, Yotam; Gruell, Henning; Schoofs, Till; Pai, Joy A; Nogueira, Lilian; Butler, Allison L; Millard, Katrina; Lehmann, Clara; Suárez, Isabelle; Oliveira, Thiago Y; Karagounis, Theodora; Cohen, Yehuda Z; Wyen, Christoph; Scholten, Stefan; Handl, Lisa; Belblidia, Shiraz; Dizon, Juan P; Vehreschild, Jörg J; Witmer-Pack, Maggi; Shimeliovich, Irina; Jain, Kanika; Fiddike, Kerstin; Seaton, Kelly E; Yates, Nicole L; Horowitz, Jill; Gulick, Roy M; Pfeifer, Nico; Tomaras, Georgia D; Seaman, Michael S; Fätkenheuer, Gerd; Caskey, Marina; Klein, Florian; Nussenzweig, Michel C
Monotherapy of HIV-1 infection with single antiretroviral agents is ineffective because error-prone HIV-1 replication leads to the production of drug-resistant viral variants1,2. Combinations of drugs can establish long-term control, however, antiretroviral therapy (ART) requires daily dosing, can cause side effects and does not eradicate the infection3,4. Although anti-HIV-1 antibodies constitute a potential alternative to ART5,6, treatment of viremic individuals with a single antibody also results in emergence of resistant viral variants7-9. Moreover, combinations of first-generation anti-HIV-1 broadly neutralizing antibodies (bNAbs) had little measurable effect on the infection10-12. Here we report on a phase 1b clinical trial ( NCT02825797 ) in which two potent bNAbs, 3BNC11713 and 10-107414, were administered in combination to seven HIV-1 viremic individuals. Infusions of 30 mg kg-1 of each of the antibodies were well-tolerated. In the four individuals with dual antibody-sensitive viruses, immunotherapy resulted in an average reduction in HIV-1 viral load of 2.05 log10 copies per ml that remained significantly reduced for three months following the first of up to three infusions. In addition, none of these individuals developed resistance to both antibodies. Larger studies will be necessary to confirm the efficacy of antibody combinations in reducing HIV-1 viremia and limiting the emergence of resistant viral variants.
PMID: 30258217
ISSN: 1546-170x
CID: 3314412