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Botulinum toxin improves forehead scars after Mohs surgery: A randomized, double-blinded, controlled study [Letter]

Lin, Matthew J; Bernstein, Daniel M; Torbeck, Richard L; Dubin, Danielle P; Rosenberg, Joshua D; Khorasani, Hooman
PMID: 33848604
ISSN: 1097-6787
CID: 5221592

The effect of platelet-rich plasma on female androgenetic alopecia: A randomized controlled trial

Dubin, Danielle P; Lin, Matthew J; Leight, Hayley M; Farberg, Aaron S; Torbeck, Richard L; Burton, William B; Khorasani, Hooman
BACKGROUND:Platelet-rich plasma (PRP) may be a useful treatment for androgenetic alopecia (AGA), although objective studies are needed. OBJECTIVE:To determine whether PRP injections improve female AGA. METHOD/METHODS:), hair caliber (mm), and blinded global photographic assessment (improved or not improved) at week 24. RESULTS:; P < .01). Compared to baseline, there was improvement in mean caliber in the PRP group versus the placebo group at week 8 (+0.0043 vs -0.0034 mm; P < .01) and week 24 (+0.0053 vs -0.0060 mm; P < .01). Adverse effects included headache, scalp tightness, swelling, redness, and postinjection bleeding. LIMITATIONS/CONCLUSIONS:Two patients lost to follow-up. CONCLUSIONS:PRP with the Eclipse system is a safe and effective intervention for female AGA.
PMID: 32649961
ISSN: 1097-6787
CID: 5221512

Emerging off-label esthetic uses of botulinum toxin in dermatology

Phan, Kevin; Younessi, Shannon; Dubin, Danielle; Lin, Matthew J; Khorasani, Hooman
Botulinum toxin is a neurotoxic protein produced by Clostridium botulinum, the bacterium responsible for botulism. Botulinum toxin was first used for therapeutic indications in the 1970s for the treatment of strabismus. With greater understanding of its underlying physiology and safety profile, the use of botulinum toxin has now expanded to a range of cosmetic and medical indications. We performed a systematic review of current literature on the applications of botulinum toxin on off-label esthetic uses. Electronic databases were searched for original published studies including randomized trials, observational or cohort studies, as well as relevant case reports. To add to the body of evidence, our review summarizes and synthesizes key study characteristics, results, and level of evidence for each use case. Although the body of evidence remains weak, there is increasing support for the use of botulinum toxin in emerging off-label esthetic uses of botulinum toxin in dermatology.
PMID: 34792262
ISSN: 1529-8019
CID: 5221612

Buccal Fat Pad Reduction With Intraoperative Fat Transfer to the Temple

Lin, Matthew J; Hazan, Ezra; John, Ann M; Dubin, Danielle P; Younessi, Shannon; Khorasani, Hooman
There is now a growing trend for buccal fat pad reduction in patients who desire a decrease in midface and lower face volume, refinement, sculpting, or enhancement of facial features. The buccal fat pad is connected to the temporal fat, and therefore buccal fat pad reduction can result in volume depletion of the temporal fossae. In addition, most patients undergoing this procedure already have pre-existing temporal volume depletion due to aging. We describe a technique in which we remove part of the buccal fat pad and transfer the fat to the temple to achieve aesthetically pleasing facial contouring.
PMID: 35180056
ISSN: 2326-6929
CID: 5221622


Chapter by: Hazan, Ezra; Khorasani, H
in: Treatment of skin disease : comprehensive therapeutic strategies by Lebwohl, Mark G; et al [Eds]
Philadelphia, PA : Elsevier, 2022
pp. ?-
ISBN: 9780702082108
CID: 5364202

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Dubin, Danielle P; Lin, Matthew J; Leight, Hayley M; Farberg, Aaron S; Torbeck, Richard L; Burton, William B; Khorasani, Hooman
PMID: 33549651
ISSN: 1097-6787
CID: 5221582

A survey of long-term results with microwave energy device for treating axillary hyperhidrosis

Lin, Matthew J; Dubin, Danielle P; Genece, Jordan; Younessi, Shannon; Rai, Sweta; Khorasani, Hooman
Microwave energy technology treats axillary hyperhidrosis through thermolysis of the apocrine and eccrine glands. Successful short-term reduction of sweating has been studied, but there is limited information on long-term efficacy and safety. To evaluate patient satisfaction with microwave energy device for axillary hyperhidrosis performed within the last 5 years. From June to August 2019, a standardized telephone survey was conducted of 24 patients who received microwave energy device treatment for bilateral axillary hyperhidrosis between June 2014 and June 2018. Demographic information, previous treatment modalities, sweat reduction scores, and side effects were reported. Eighteen patients completed the survey with a mean follow-up of 38 months (range 12-52). The mean hyperhidrosis disease severity scale (HDSS) was reduced by 1.6 (95% CI 1.2-2.0, p < .01). The mean sweat reduction was 61-70%. Sixty-seven percent of patients experienced a reduction in odor and 54% did not require deodorant after treatment. Adverse effects included bruising (67%), pain (56%), swelling (44%), numbness (28%), and nodules (22%). Sixty-six percent of side effects resolved within 2 weeks and all side effects resolved within 12 weeks. The microwave energy device is an effective, durable therapy for axillary hyperhidrosis associated with minimal downtime and a high degree of long-term patient satisfaction.
PMID: 34409892
ISSN: 1476-4180
CID: 5221602

Polydioxanone Threads for Atrophic Neck Scars

Dubin, Danielle P; Lin, Matthew J; Akselrad, Melissa D; Khorasani, Hooman
PMID: 32769520
ISSN: 1524-4725
CID: 5221522

Brief Educational Video Improves Patient Understanding of Mohs Surgery: A Randomized Controlled Trial

Lin, Matthew J; Dubin, Danielle P; Younessi, Shannon; Khorasani, Hooman
BACKGROUND:Patient's retention and recall of material discussed in a medical consultation is often inadequate. OBJECTIVE:To assess patient's knowledge, anxiety, and understanding of Mohs surgery after viewing a brief educational video. METHOD:A prospective, investigator-blinded, randomized controlled trial of 120 consecutive patients before the first Mohs surgery procedure. Sixty subjects viewed an instructional video and 60 subjects did not. A survey was administered to both groups, measuring knowledge, anxiety, and understanding of Mohs surgery. RESULTS:The video group scored higher than the control group on the knowledge portion of the survey (median score 78% vs 56%, p < .01), but there were no differences in anxiety or understanding scores between groups. The percentage of subjects who answered each knowledge question correctly was greater in the video group than in the control group. In the subgroup of patients who had not previously had a consultation with a Mohs surgeon, the video group had higher median knowledge scores (67% vs 44%, p < .01), higher median understanding scores (8 vs 6, p = .05), and lower median visual analogue anxiety scores (4 vs 6, p = .01) compared with the control group. CONCLUSION:A brief educational video increases patient's knowledge of Mohs surgery. For patients who have not yet had a consultation with a Mohs surgeon, the video may also reduce anxiety.
PMID: 33337731
ISSN: 1524-4725
CID: 5221572

The potential role of cannabinoids in dermatology

Sheriff, Tabrez; Lin, Matthew J; Dubin, Danielle; Khorasani, Hooman
Cannabis is increasingly being used world-wide to treat a variety of dermatological conditions. Medicinal cannabis is currently legalized in Canada, 31 states in America and 19 countries in Europe. The authors reviewed the literature on the pharmacology and use of cannabinoids in treating a variety of skin conditions including acne, atopic dermatitis, psoriasis, skin cancer, pruritus, and pain. Cannabinoids have demonstrated anti-inflammatory, antipruritic, anti-ageing, and antimalignancy properties by various mechanisms including interacting with the newly found endocannabinoid system of the skin thereby providing a promising alternative to traditional treatments.
PMID: 31599175
ISSN: 1471-1753
CID: 5221462