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Patient Outcomes After Single-level Coflex Interspinous Implants Versus Single-level Laminectomy

Zhong, Jack; O'Connell, Brooke; Balouch, Eaman; Stickley, Carolyn; Leon, Carlos; O'Malley, Nicholas; Protopsaltis, Themistocles S; Kim, Yong H; Maglaras, Constance; Buckland, Aaron J
STUDY DESIGN/METHODS:Retrospective cohort analysis. OBJECTIVE:The aim of this study was to compare postoperative outcomes of Coflex interspinous device versus laminectomy. SUMMARY OF BACKGROUND DATA/BACKGROUND:Coflex Interlaminar Stabilization device (CID) is indicated for one- or two-level lumbar stenosis with grade 1 stable spondylolisthesis in adult patients, as an alternative to laminectomy, or laminectomy and fusion. CID provides stability against progressive spondylolisthesis, retains motion, and prevents further disc space collapse. METHODS:Patients ≥18 years' old with lumbar stenosis and grade 1 stable spondylolisthesis who underwent either primary single-level decompression and implantation of CID, or single-level laminectomy alone were included with a minimum 90-day follow-up at a single academic institution. Clinical characteristics, perioperative outcomes, and postoperative complications were reviewed until the latest follow-up. χ2 and independent samples t tests were used for analysis. RESULTS:Eighty-three patients (2007-2019) were included: 37 cases of single-level laminectomy (48.6% female) were compared to 46 single-level CID (50% female). CID cohort was older (CID 69.0 ± 9.4 vs. laminectomy 64.2 ± 11.0, P = 0.042) and had higher American Society of Anesthesiologists (ASA) grade (CID 2.59 ± 0.73 vs. laminectomy 2.17 ± 0.48, P = 0.020). CID patients had higher estimated blood loss (EBL) (97.50 ± 77.76 vs. 52.84 ± 50.63 mL, P = 0.004), longer operative time (141.91 ± 47.88 vs. 106.81 ± 41.30 minutes, P = 0.001), and longer length of stay (2.0 ± 1.5 vs. 1.1 ± 1.0 days, P = 0.001). Total perioperative complications (21.7% vs. 5.4%, P = 0.035) and instrumentation-related complication was higher in CID (10.9% vs. 0% laminectomy group, P = 0.039). There were no other significant differences between the groups in demographics or outcomes. CONCLUSION/CONCLUSIONS:Single-level CID devices had higher perioperative 90-day complications, longer operative time, length of stay, higher EBL compared to laminectomies alone. Similar overall revision and neurologic complication rates were noted compared to laminectomy at last follow-up.Level of Evidence: 3.
PMID: 33395022
ISSN: 1528-1159
CID: 4923872

Anterior Approach to the Subaxial Cervical Spine: Pearls and Pitfalls

Razi, Afshin; Saleh, Hesham; DeLacure, Mark D; Kim, Yong
Since its introduction by Smith and Robinson, the anterior approach to the subaxial cervical spine has become one of the standard procedures for numerous cervical spine pathologies, including, but not limited to degenerative disease, trauma, tumor, deformity, and instability. Along with its increasing popularity and improvements in anterior instrumentation techniques, a comprehensive knowledge of the surgical anatomy during the anterior exposure is critical for trainees and experienced spine surgeons alike to minimize the infrequent but potentially devastating risks associated with this approach. Understanding the anatomy and techniques to minimize damage to relevant structures can reduce the risks of developing notable postoperative complications and morbidity.
PMID: 33587498
ISSN: 1940-5480
CID: 4786492

Lumbar Endoscopic Spine Surgery A Comprehensive Review

Shepard, Nicholas A; Protopsaltis, Themistocles; Kim, Yong
Endoscopic spine surgery (ESS) is growing in popularity as a minimally invasive approach to a variety of spinal conditions. Similar to other types of minimally invasive spine surgery (MISS), ESS aims to address the underlying pathology while minimizing surrounding tissue disruption. Its use in the lumbar spine has progressed over the past 50 years and is now routinely used in cases of lumbar disc herniations and stenosis. This review defines common terminology, highlights important developments in the history of ESS, and discusses its current and future application in the lumbar spine.
PMID: 33704036
ISSN: 2328-5273
CID: 4835962

P138. Crossing the junction: effect of fusion length on reoperations for revision thoracolumbar fusion to sacrum [Meeting Abstract]

Zhong, J; Balouch, E; O'Malley, N; Leon, C; Stickley, C; Maglaras, C; Ayres, E W; Patel, K S; Kim, Y H; Protopsaltis, T S; Buckland, A J
BACKGROUND CONTEXT: The thoracolumbar junction poses increased risk for high stress on upper lumbar discs when not adequately fused. However, controversy persists. This study evaluates outcomes of upper instrumented vertebrae (UIV) selection in the thoracic versus the upper lumbar spine when fusing to the sacrum. PURPOSE: To compare revision rates for thoracolumbar fusions to the sacrum and pelvis at 1- and 2-year follow-up, stratified by UIV selection. STUDY DESIGN/SETTING: Retrospective cohort study at a single institution. PATIENT SAMPLE: A total of 968 patients who had thoracolumbar fusion surgery between 2012-2018 with at least one year of postoperative follow-up. OUTCOME MEASURES: Reoperation rates from 1 and 2 years after revision surgery, reoperation diagnoses, body mass index (BMI), gender, Charleston Comorbidity Index (CCI), perioperative complications, ASA grade (ASA), operative time (OT), and blood loss (EBL).
METHOD(S): A retrospective review of patients undergoing revision spinal fusion with lower instrumented vertebra of S1 or pelvis between 2012-2018 at a single institution was performed. Patients with less than 1 year of follow-up after their index procedure were excluded from the analysis. Patients were categorized based on UIV into 6 groups: T9-T11, L1, L2, L3, L4, and L5. Demographic and operative data were collected and compared between the different UIV groups in each cohort using chi-squared and ANOVA tests. Revision rates at 1- and 2-year follow-up and the reasons for revision were compared between groups.
RESULT(S): There were 168 revision spinal fusions that reached 1-year follow-up, with 54 having UIV at T9-T11, 2 fusions L1 to sacrum, 26 fusions L2 to sacrum, 25 fusions L3 to sacrum, 36 fusions L4 to sacrum, 23 fusions L5 to sacrum. There was significant difference in patient age, with oldest in the L1 group (65.5+/-3.5) and youngest in the L5 group (51+/-15.4 p<0.001). There was significant difference in gender as both cases in L2 was female and L5 fusions only had 39.1% females (p = 0.006). There were no differences in BMI, CCI, and ASA. EBL (1891.6mL+/-1226.9mL p <0.001) and length of stay (7.7+/-3.0 p <0.001) was highest in the T9-11 UIV group. Operative time was highest in the L1 (464.5+/-174.7 p<0.001) UIV group. Levels added on top of prior fusion were calculated by subtracting UIV of index fusion to past UIV. Adding on 2 levels had a 1-year revision rate of 14.3% (p = 0.032), while adding on 1 level had a 0% 1-year revision rate. Adding on 4 levels had a revision rate of 12.5%, and adding on 7 levels had a 50% 1-year revision rate. At 2 years, adding on 1 level had revision rate of 25% and adding on 2 levels had a revision rate of 20% (p = 0.769). There is no statistically significant difference in perioperative complication rates between UIV groups (p = 0.114). The reoperation rate at 1 year for all levels was 9% and highest in UIV at L1 (50%, p=0.06). At 2-year follow-up, the reoperation rate for the total cohort was 32.34% with the highest revision rate for fusion from L2 to sacrum (53.85%) followed by (T9-T11 sacrum fusion 42.31%, L4 to sacrum31.71%, L3 to sacrum 30%, L5 to sacrum 25.04%, L1 to sacrum 25%, p=0.195). Grouping the UIV into lower thoracic (T9-T11), upper lumbar (L2-L3), and lower lumbar (L4-L5) showed similar revision rates at one year (p=0.697). At two years, lower thoracic group had a revision rate of 40% versus, 23.3% in the upper lumbar group (p =0.399).
CONCLUSION(S): There is no statistically significant difference in reoperation rates for revision thoracolumbar fusions to the sacrum/pelvis associated with different UIV selection. FDA DEVICE/DRUG STATUS: This abstract does not discuss or include any applicable devices or drugs.
Copyright
EMBASE:2007747344
ISSN: 1878-1632
CID: 4597372

123. Residual foraminal stenosis and increasing levels decompressed are risk factors for postoperative C5 palsy [Meeting Abstract]

Brenner, R; Stickley, C; Balouch, E; O'Malley, N; Zhong, J; Leon, C; Maglaras, C; Ayres, E W; Kim, Y H; Buckland, A J
BACKGROUND CONTEXT: C5 palsy stands as a known but poorly understood complication of cervical spine surgery with rates reported as high as 30%. Although there are multiple studies presenting different risk factors, variability in findings have led to controversy in the etiology of postoperative C5 palsy. PURPOSE: To evaluate factors that predispose a patient to developing C5 palsy following cervical spine surgery. STUDY DESIGN/SETTING: Retrospective review of a large single center academic institution. PATIENT SAMPLE: This study included 239 cervical spinal procedures from 2013 to 2018. OUTCOME MEASURES: Patient demographics, surgical procedure and approach, perioperative clinical characteristics, postoperative rate of C5 palsy, C5 palsy resolution, and radiographic outcomes.
METHOD(S): Patients >=18 years of age who underwent cervical spinal surgery including the C4/C5 level, with minimum 1-year follow-up were included. C5 palsy was defined as deltoid +/- bicep weakness with Modified Rankin Scale grading at least 1 point below baseline (BL). Characteristics studied include: demographics, surgical procedure and approach (decompression and/or fusion). Radiographic analyses of MRI and CT measurements of foramen dimensions and spinal cord drift at BL and follow-up were performed. Statistical analyses included t-tests, chi-square analysis, and multivariate logistic regression to determine independent predictive factors. A receiver operating characteristic curve was run to determine the cutoff levels for predictive factors. Significance set at p<0.05.
RESULT(S): A total of 239 patients were included, with a C5 palsy rate of 6.3% for all cases. Subjects that developed C5 palsy were older (64.67+/-8.61 vs 57.56+/-11.61, p=0.021), had more levels decompressed posteriorly (3.20+/-1.82 vs 1.12+/-1.74, p<0.001), a higher rate of preoperative myelomalacia (60% vs 19.6%, p=0.008), and higher CCI (3.80+/-1.97 vs 2.35+/-1.95, p=0.005). Anterior cervical discectomy and fusion (ACDF) surgeries had a 2.4% rate of C5 palsy while the posterior approach rate was 11.9% (p<0.007). The highest rate was in laminectomy and posterior fusion at 15.2% (p<0.001). There were no significant differences in palsy resolution between those treated surgically compared to those not treated. Radiographically, C5 palsy patients had smaller postoperative foramen width measurements than those who did not develop C5 palsy (2.16+/-1.04 vs 3.31+/-1.25, p=0.023 on the right; 1.84+/-0.80 vs 3.02+/-1.25, p=0.014 on the left). When controlling for technique, CCI, age, BMI, and myelomalacia, multivariate regression analysis revealed increasing levels of laminectomy to be a significant independent predictor of C5 palsy (1.602 (2.258-1.136) for each additional level decompressed, p=0.007). The cut-off value for levels decompressed via laminectomy was determined to be 3.50 levels (>=0.7 AUC <=0.8). Postoperative foramen width was also an independent risk factor for C5 palsy (0.009 (0.000-0.726), p=0.035), it was determined that risk of C5 palsy increases at <2.625mm foramen width (>=0.8 AUC <=0.9).
CONCLUSION(S): C5 palsy following cervical spine surgery is correlated with residual postoperative foraminal stenosis and posterior surgery with increasing number levels decompressed. Patients undergoing more than 3.5 level laminectomy with less than 2.625mm foramen width postoperatively are at highest risk of developing C5 palsy. FDA DEVICE/DRUG STATUS: This abstract does not discuss or include any applicable devices or drugs.
Copyright
EMBASE:2007747285
ISSN: 1878-1632
CID: 4597472

Preoperative MRI Predictors of Health Related Quality of Life Improvement after Microscopic Lumbar Discectomy

Varlotta, Christopher G; Manning, Jordan H; Ayres, Ethan W; Wang, Erik; Woo, Dainn; Vasquez-Montes, Dennis; Alas, Haddy; Brown, Avery; Egers, Max; Kim, Yong; Bendo, John A; Fischer, Charla R; Protopsaltis, Themistocles S; Stieber, Jonathan R; Buckland, Aaron J
BACKGROUND:Lumbar herniated nucleus pulposus (HNP) is a common spinal pathology often treated by microscopic lumbar discectomy (MLD), though prior reports have not demonstrated which preoperative MRI factors may contribute to significant clinical improvement after MLD. PURPOSE/OBJECTIVE:To analyze the MRI characteristics in patients with HNP that predict meaningful clinical improvement in Health Related Quality of Life scores (HRQoL) after MLD. STUDY DESIGN/SETTING/METHODS:Retrospective clinical and radiological study of patients undergoing MLD for HNP at a single institution over a two-year period. PATIENT SAMPLE/METHODS:88 patients receiving MLD treatment for HNP. OUTCOME MEASURES/METHODS:Cephalocaudal Canal Migration; Canal & HNP Anterior-Posterior (AP) Lengths and Ratio; Canal & HNP Axial Areas and Ratio; Hemi-Canal & Hemi-HNP Axial Areas and Ratio; Disc appearance (black, grey or mixed), Baseline (BL) and 3-Month (3M) postoperative Health Related Quality of Life Scores. METHODS:Patients > 18 years old who received MLD for HNP with BL and 3M HRQoL scores of PROMIS (Physical Function, Pain Interference, and Pain Intensity), ODI, VAS Back, and VAS Leg scores were included. HNP and spinal canal measurements of cephalocaudal migration, AP length, area, hemi-area, and disc appearance were performed using T2 axial and sagittal MRI. HNP measurements were divided by corresponding canal measurements to calculate AP, Area, and Hemi-Area ratios. Using known minimal clinically important differences (MCID) for each ΔHRQoL score, patients were separated into two groups based on whether they reached MCID (MCID+) or did not reach MCID (MCID-). The MCID for PROMIS Pain Intensity was calculated using a decision tree. A linear regression illustrated correlations between PROMIS vs ODI and VAS Back/Leg scores. Independent t-tests and chi [2] tests were utilized to investigate significant differences in HNP measurements between the MCID+ and MCID- groups. RESULTS:± 43.2, p<.04). MCID+ patients had a greater Hemi-Area Ratio than MCID- patients had in 4 out of 6 HRQoL score comparisons (51.8% ± 14.7 vs 43.9% ± 14.9, p<.05). CONCLUSIONS:Patients who met MCID after MLD had larger HNP areas and larger Hemi-HNP Areas than those who did not meet MCID. These patients were also 2.7x more likely to have a grey MRI signal than a mixed or black MRI signal. When accounting for HNP area relative to canal area, patients who met MCID had greater Hemi-HNP canal occupation than patients who did not meet MCID. The results of this study suggest that preoperative MRI parameters can be useful in predicting patient reported improvement after MLD.
PMID: 31580903
ISSN: 1878-1632
CID: 4116372

A Practical Approach to Spine Magnetic Resonance Imaging

Shepard, Nicholas; Samim, Mohammad; Kim, Yong; Razi, Afshin
PMID: 32224632
ISSN: 2329-9185
CID: 4371252

MRI Radiological Predictors of Requiring Microscopic Lumbar Discectomy After Lumbar Disc Herniation

Varlotta, Christopher G; Ge, David H; Stekas, Nicholas; Frangella, Nicholas J; Manning, Jordan H; Steinmetz, Leah; Vasquez-Montes, Dennis; Errico, Thomas J; Bendo, John A; Kim, Yong H; Stieber, Jonathan R; Varlotta, Gerard; Fischer, Charla R; Protopsaltis, Themistocles S; Passias, Peter G; Buckland, Aaron J
Study Design/UNASSIGNED:Retrospective cohort study. Objective/UNASSIGNED:To investigate radiological differences in lumbar disc herniations (herniated nucleus pulposus [HNP]) between patients receiving microscopic lumbar discectomy (MLD) and nonoperative patients. Methods/UNASSIGNED:test and chi-square analyses compared differences in the groups, binary logistic regression analysis determined odds ratios (ORs), and decision tree analysis compared the cutoff values for risk factors. Results/UNASSIGNED:< .01). Conclusion/UNASSIGNED:Patients who underwent MLD treatment had significantly different axial HNP area, frequency of caudal migration, magnitude of cephalad/caudal migration, and disc herniation MRI signal compared to patients with nonoperative treatment.
PMCID:6963358
PMID: 32002351
ISSN: 2192-5682
CID: 4294392

Acoustofluidic Salivary Exosome Isolation: A Liquid Biopsy Compatible Approach for Human Papillomavirus-Associated Oropharyngeal Cancer Detection

Wang, Zeyu; Li, Feng; Rufo, Joseph; Chen, Chuyi; Yang, Shujie; Li, Liang; Zhang, Jinxin; Cheng, Jordan; Kim, Yong; Wu, Mengxi; Abemayor, Elliot; Tu, Michael; Chia, David; Spruce, Rachel; Batis, Nikolaos; Mehanna, Hisham; Wong, David T W; Huang, Tony Jun
Previous efforts to evaluate the detection of human papilloma viral (HPV) DNA in whole saliva as a diagnostic measure for HPV-associated oropharyngeal cancer (HPV-OPC) have not shown sufficient clinical performance. We hypothesize that salivary exosomes are packaged with HPV-associated biomarkers, and efficient enrichment of salivary exosomes through isolation can enhance diagnostic and prognostic performance for HPV-OPC. In this study, an acoustofluidic (the fusion of acoustics and microfluidics) platform was developed to perform size-based isolation of salivary exosomes. These data showed that this platform is capable of consistently isolating exosomes from saliva samples, regardless of viscosity variation and collection method. Compared with the current gold standard, differential centrifugation, droplet digital RT-PCR analysis showed that the average yield of salivary exosomal small RNA from the acoustofluidic platform is 15 times higher. With this high-yield exosome isolation platform, we show that HPV16 DNA could be detected in isolated exosomes from the saliva of HPV-associated OPC patients at 80% concordance with tissues/biopsies positive for HPV16. Overall, these data demonstrated that the acoustofluidic platform can achieve high-purity and high-yield salivary exosome isolation for downstream salivary exosome-based liquid biopsy applications. Additionally, HPV16 DNA sequences in HPV-OPC patients are packaged in salivary exosomes and their isolation will enhance the detection of HPV16 DNA.
PMID: 31843276
ISSN: 1943-7811
CID: 4242292

The Military Medical System and Wartime Injuries to the Spine

Shenoy, Kartik; Kim, Yong H
War has historically been a major catalyst for advancement in military medical care and medicine in general. In our current conflicts, advances in battlefield medicine, evacuation techniques, and personal protective equipment have improved survival rates among members of the armed services. With increased survival, there has been increased prevalence of serious but nonfatal injuries, particularly from blunt and penetrating trauma. Blast injuries are the major cause of trauma and have both blunt and penetrating components. With respect to the spine, blasts have led to open, contaminated wounds that are complex and difficult to treat. Additionally, blasts have led to an increased incidence of lower lumbar burst fractures and lumbosacral dissociation. As these and other injuries are being seen more commonly during war, we must ensure that our military medical system is adapting to ensure we are taking care of our military personnel at the highest level.
PMID: 32144962
ISSN: 2328-5273
CID: 4390232