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Impact of COVID-19 on HPV Vaccination Rates in New York City and Long Island

Bower, Maria; Kothari, Ulka; Akerman, Meredith; Krilov, Leonard R; Fiorito, Theresa M
BACKGROUND:In the United States, uptake of human papillomavirus (HPV) vaccination has been exceptionally low as compared with other vaccines. During the coronavirus disease (COVID-19) pandemic, routine vaccinations were deferred or delayed, further exacerbating HPV vaccine hesitancy. The specific effect of the pandemic on HPV vaccination rates in the United States has not been yet described. METHODS:We aimed to determine the percentage of children achieving full HPV vaccination (2 doses) by age 15 years and to compare prepandemic to pandemic rates of HPV vaccination at pediatric practices across our institution. A retrospective chart review was performed to compare HPV vaccination rates in the "prepandemic" and "pandemic" periods for all children 9 through 14 years of age. Additionally, peaks in COVID-19 positivity were compared with HPV vaccination rates. RESULTS:Of children 9-14 years old, 49.3% received at least 1 dose of HPV vaccine in the prepandemic period, compared with 33.5% during the pandemic ( P < 0.0001). Only 33.5% of patients received the full 2-dose series of HPV prepandemic, compared with 19.0% of patients during the pandemic ( P < 0.0001). When COVID-19 positivity rates peaked, HPV vaccination also declined. CONCLUSIONS:The issue of low HPV vaccination rates was amplified due to the COVID-19 pandemic, as illustrated by the correlation between peaks in COVID-19 positivity and low rates of HPV vaccination.
PMID: 37963272
ISSN: 1532-0987
CID: 5610662

Pneumocystis Pneumonia

Noor, Asif; Krilov, Leonard R
PMID: 38036438
ISSN: 1526-3347
CID: 5590432


Noor, Asif; Krilov, Leonard R
PMID: 37907416
ISSN: 1526-3347
CID: 5609672

Increasing Rates of RSV Hospitalization among Preterm Infants: A Decade of Data

Kong, Amanda M; Winer, Isabelle H; Zimmerman, Nicole M; Diakun, David; Bloomfield, Adam; Gonzales, Tara; Fergie, Jaime; Goldstein, Mitchell; Krilov, Leonard R
OBJECTIVE: In 2014, the American Academy of Pediatrics (AAP) changed its policy on the use of respiratory syncytial virus immunoprophylaxis (RSV-IP) so that RSV-IP was no longer recommended for use among infants without other medical conditions born >29 weeks gestational age (wGA). This study examines 10-year trends in RSV-IP and RSV hospitalizations among term infants and preterm infants born at 29 to 34 wGA, including the 5 RSV seasons before and 5 RSV seasons after the AAP guidance change. STUDY DESIGN/METHODS: A retrospective observational cohort study of a convenience sample of infants less than 6 months of age during RSV season (November-March) born between July 1, 2008, and June 30, 2019, who were born at 29 to 34 wGA (preterm) or >37 wGA (term) in the IBM MarketScan Commercial and Multi-State Medicaid databases. We excluded infants with medical conditions that would independently qualify them for RSV-IP. We identified RSV-IP utilization along with RSV and all-cause bronchiolitis hospitalizations during each RSV season. A difference-in-difference model was used to determine if there was a significant change in the relative rate of RSV hospitalizations following the 2014 policy change. RESULTS:<0.001, respectively). Findings were similar for all-cause bronchiolitis hospitalizations. CONCLUSION/CONCLUSIONS: We found that the previously identified increase in RSV hospitalization rates among infants born at 29 to 34 wGA persisted for at least 5 years following the policy change. KEY POINTS/CONCLUSIONS:· Immunoprophylaxis rates decreased after the 2014 American Academy of Pediatrics guidelines update.. · Rate of RSV hospitalization increased among preterm infants after the 2014 AAP guidelines update.. · Increase in RSV hospitalization persisted for at least 5 years after AAP guidelines update..
PMID: 34704241
ISSN: 1098-8785
CID: 5042452

Messenger RNA Vaccine in Mother's Milk-Reply

Hanna, Nazeeh; Clauss, Christie; Krilov, Leonard R
PMID: 36804769
ISSN: 2168-6211
CID: 5433782

Rabies: Reality Bites

Fiorito, Theresa M; Krilov, Leonard R
PMID: 36720676
ISSN: 1526-3347
CID: 5420012

Clinical Outcomes of Children With Extended-spectrum ß -Lactamase Urinary Tract Infection Receiving Discordant Empiric Antibiotic: A Comparative Study of Fever Duration, Length of Stay, and Readmissions

Begaj, Xhesika; Lee, Hannah; Noor, Asif; Fiorito, Theresa; Agarwalla, Vipin; Kambhampati, Ooha; Islam, Shahidul; Krilov, Leonard R
There has been a recent increase in the incidence of urinary tract infections (UTIs) caused by extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae, which are resistant to third-generation cephalosporins. Our goal was to compare the clinical responses of patients with ESBL UTI and non-ESBL UTI who received empiric third-generation cephalosporins. A retrospective analysis was performed on data collected between June 1, 2013, and June 30, 2017, from children aged 0 days to 19 years old who presented to NYU Langone Long Island Hospital's pediatric ED and/or were admitted with a UTI caused by Enterobacteriaceae. There was no significant difference in median length of fever duration. However, ESBL patients had significantly longer hospital stays, higher 30-day readmission rate, and higher 7-day revisit rate. It is reasonable to maintain an empiric UTI antibiotic choice rather than selecting a broad-spectrum antibiotic, such as carbapenem for children at high risk of ESBL UTI.
PMID: 36199269
ISSN: 1938-2707
CID: 5351642

Respiratory Syncytial Virus (RSV) Update [Editorial]

Krilov, Leonard R; Roberts, Norbert J
Since the initial identification of respiratory syncytial virus (RSV) in 1956, much has been learned about the epidemiological impact and clinical manifestations of RSV infections [...].
PMID: 36298665
ISSN: 1999-4915
CID: 5358132

EDP-938 demonstrates efficacy against RSV [Comment]

Krilov, Leonard R
PMID: 36058600
ISSN: 1097-6833
CID: 5335982

Diagnosing PFAPA during the COVID-19 era: clarity during quarantine [Letter]

Fiorito, Theresa; Akerman, Meredith; Noor, Asif; Krilov, Leonard R
PMID: 35190384
ISSN: 1468-2044
CID: 5172042