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Congenitally corrected transposition of the great arteries

Kumar, T K Susheel
Congenitally corrected transposition of the great arteries (CCTGA) is a rare congenital heart lesion with varied morphological presentation and can often by asymptomatic. A failing systemic right ventricle (RV) or increasing tricuspid regurgitation are generally indications for surgical intervention. The surgical approach depends upon the age of the patient and morphology of the lesion. Anatomical correction is associated with satisfactory long-term results.
PMCID:7139005
PMID: 32274202
ISSN: 2072-1439
CID: 4379062

Practical conduct of open heart procedures for congenital heart lesions

Kumar, T K Susheel
Open heart surgery on infants with congenital heart lesions can be challenging not only in terms of the surgical procedure itself but also for setting up ideal conditions for safe and smooth conduct of cardiopulmonary bypass (CPB). The surgeon has to deal with a variety of lesions in a subgroup of patients who offer little room for any error. Familiarity with the principles of CPB, check lists and protocols go a long way in improving outcome in this critical group of patients.
PMCID:7139054
PMID: 32274205
ISSN: 2072-1439
CID: 4379072

Investigation of a novel method for improving the hemodynamics of the failing Fontan circuit using an experimental model [Meeting Abstract]

Kumar, T K S; Katre, N R
Objective: The objective of this experimental study was to test the underlying physical laws behind a proposed novel device for failing Fontan and to investigate whether the device could be implemented theoretically to improve hemodynamics in failing Fontan circulation.
Method(s): A 4-arm setup (Figure 1) was designed and fabricated to simulate an actual Fontan circuit in the form of a junction of the superior and inferior vena cava (SVC, IVC) and the right and left pulmonary arteries (RPA, LPA). A provision for placement of an oscillating ball along the RPA-LPA path to provide a push to the fluid away from SVC and IVC was created. The setup was designed to vary the rate of oscillation of the ball, and the initial pressure of the fluid on SVC and IVC limbs. The time for pressure drop at the SVC and IVC was measured at varying oscillations of the ball and varying resistances in the RPA-LPA pathway. The test was considered positive if increasing oscillations of the ball allowed for quicker pressure drop in the SVC and IVC (indicating quicker discharge of fluid through the LPA and RPA). A total of 48 different experiments were conducted to simulate different physical conditions including without the ball and a graph of the results was plotted and analyzed to conclude (Graph 1).
Result(s): The time required for pressure drop in the experiment without the ball was the least across all set of readings. This meant that placing an oscillating ball along the RPA-LPA path obstructed fluid flow rather than enhancing it. It was also observed that increasing the rate of oscillation of the ball increased the degree of obstruction to flow.
Conclusion(s): The proposed novel method for intervention is not a suitable option for improving hemodynamics in failing Fontan circulation. (Figure Presented)
EMBASE:631570601
ISSN: 1525-1594
CID: 4416572

Commentary: Devil is in the details...and good judgment! [Editorial]

Kumar, T K S; Knott-Craig, C J
EMBASE:2006115768
ISSN: 2666-2507
CID: 4549722

Experience of a single institution with femoral vein homograft as right ventricle to pulmonary artery conduit in stage 1 Norwood operation

Kumar, T K Susheel; Zurakowski, David; Briceno-Medina, Mario; Shah, Aditya; Sathanandam, Shyam; Allen, Jerry; Sandhu, Hitesh; Joshi, Vijaya M; Boston, Umar; Knott-Craig, Christopher J
OBJECTIVE:Femoral vein homograft can be used be used as valved right ventricle to pulmonary artery conduit in the Norwood operation. We describe the results of this approach, including pulmonary artery growth and ventricular function. METHODS:A retrospective chart review of 24 consecutive neonates with hypoplastic left heart syndrome or complex single ventricle undergoing this approach between June 2012 and December 2017 was performed. Conduit valve competency and ventricular function were estimated using transthoracic echocardiogram, and pulmonary artery growth was measured using Nakata's index. Changes in ventricular function pre-Glenn and at latest follow-up were assessed by ordinal logistic regression with a general linear model to account for the correlation within the same patient over time. RESULTS:). Right ventricular function was preserved in 83% of patients at a median follow-up of 34 (interquartile range, 10-46) months. CONCLUSIONS:Femoral vein homograft as a right ventricle to pulmonary artery conduit in the Norwood operation is safe and associated with good pulmonary artery growth and preserved ventricular function as assessed by subjective echocardiography. Catheter intervention of the conduit may be necessary.
PMID: 31204139
ISSN: 1097-685x
CID: 4418452

Utility of the Medtronic microvascular plugâ„¢ as a transcatheter implantable and explantable pulmonary artery flow restrictor in a swine model

Khan, Abdul H; Hoskoppal, Deepthi; Kumar, T K Susheel; Bird, Lindsey; Allen, Kimberly; Lloyd, Hannah; Knott-Craig, Christopher J; Waller, B Rush; Sathanandam, Shyam
BACKGROUND:A surgical pulmonary artery band (PAB) is used to control excessive pulmonary blood flow for certain congenital heart diseases. Previous attempts have been made to develop a transcatheter, implantable pulmonary flow restrictor (PFR) without great success. We modified a microvascular plug (MVP) to be used as a PFR. The objectives of this study were to demonstrate feasibility of transcatheter implantation and retrieval of the modified MVP as a PFR, and compare PA growth while using the PFR versus PAB. METHODS AND RESULTS/RESULTS:The PFR was implanted in eight newborn piglets in bilateral branch pulmonary arteries (PAs). Immediately post-PFR implantation, the right ventricular systolic pressure increased from a median of 20-51 mmHg. Transcatheter retrieval of PFR was 100% successful at 3, 6, and 9 weeks and 50% at 12-weeks post-implant. A left PAB was placed via thoracotomy in four other newborn piglets. Debanding was performed 6-weeks later via balloon angioplasty. On follow-up, the proximal left PA diameters in the PFR and the PAB groups were similar (median 8 vs. 7.1 mm; p = 0.11); albeit the surgical band sites required repeat balloon angioplasty secondary to recurrent stenosis. By histopathology, there was grade II vessel injury in two pigs immediately post-retrieval of PFR that healed by 12 weeks. CONCLUSIONS:Transcatheter implantation and retrieval of the MVP as a PFR is feasible. PA growth is comparable to surgical PAB, which is likely to require reinterventions. The use of the MVP as a PFR in humans has to be trialed before recommending its routine use.
PMID: 30828988
ISSN: 1522-726x
CID: 3961442

An Innovative Ventricular Assist Device Strategy as a Bridge-to-Recovery in an Infant with Glenn Physiology

Boston, Umar; Sun, John X; Kumar, T K Susheel; Knott-Craig, Christopher
Mechanical circulatory support for infants with single ventricle physiology remains challenging. Utilization of a ventricular assist device (VAD) has potential advantages over extracorporeal circulatory membrane oxygenation. As such, VAD utilization in single ventricle patients with refractory heart failure continues to be explored. Herein, we describe a novel VAD strategy to support an infant with Glenn physiology who presented in cardiogenic shock related to myocardial depression of unknown etiology. This VAD configuration supported the systemic circulation independent of the Glenn circulation. Seven days of VAD support resulted in recovery of myocardial and end-organ function leading to VAD removal. The patient remains alive and free from transplantation 16 months post VAD explantation.
PMID: 30281543
ISSN: 1538-943x
CID: 3664592

Successful Heart Transplantation in Two Infants With Dextrocardia-Heterotaxy Syndrome

Boston, Umar; Kumar, Tk Susheel; Shah, Jignesh; Street, Tiffany; Towbin, Jeffrey; Knott-Craig, Christopher J
Infants with dextrocardia-heterotaxy syndrome pose significant surgical challenges to a successful orthotopic heart transplant. Herein we report on 2 infants with dextrocardia-heterotaxy syndrome who underwent complex heart transplantation. A combination of preoperative 3-dimensional chest computed tomography to predict optimal donor size and unique surgical technique resulted in successful outcomes.
PMID: 30081023
ISSN: 1552-6259
CID: 3664612

Biventricular root replacement for transcatheter pulmonary valve endocarditis after Ross operation: Double the trouble

Kumar, T K Susheel; Balduf, Kaitlin; Boston, Umar; Knott-Craig, Christopher
PMID: 30391009
ISSN: 1097-685x
CID: 3664602

Surgical management of patent ductus arteriosus

Susheel Kumar, Thittamaranahalli Kariyappa
Surgical ligation of patent ductus arteriosus can be performed safely by following standard steps of operation. Familiarity of the anatomical landmarks and simple precautions result in high degree of safety. The technique of surgical ligation varies with the age of the patient. Surgical ligation of ductus is associated with well-recognized complications, although they occur only in a small number of patients.
PMID: 30811804
ISSN: 1747-0803
CID: 4418472