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No Effect Of Resistin Deficiency On Airway Responses To Acute Ozone Exposure [Meeting Abstract]

Razvi, S. S.; Cockerill, K. J.; Alexander, A. L.; Price, R. E.; Cromar, K. R.; Malik, F.; Dahm, P. H.; Haque, I. U.; Lazar, M. A.; Johnston, R. A.
ISSN: 1073-449x
CID: 2960122

Multivariate analysis of factors associated with kyphosis maintenance in adolescent idiopathic scoliosis

Lonner, Baron S; Lazar-Antman, Meredith A; Sponseller, Paul D; Shah, Suken A; Newton, Peter O; Betz, Randal; Shufflebarger, Harry S
STUDY DESIGN.: Multicenter retrospective cohort study of 269 patients. OBJECTIVE.: The purpose of this study is to evaluate the surgical and radiographical factors in adolescent idiopathic scoliosis (AIS) surgery that significantly affect kyphosis maintenance. SUMMARY OF BACKGROUND DATA.: Decreased kyphosis in the thoracic spine is a component of the 3-dimensional deformity in AIS. Suboptimal sagittal alignment after spinal fusion has been identified as a possible cause of lumbar and cervical spinal degeneration and junctional malalignment. Segmental spinal instrumentation continues to evolve, and although excellent coronal plane correction is readily achieved, sagittal plane thoracic hypokyphosis may be seen postoperatively. METHODS.: A retrospective analysis of prospectively collected data from a multicenter AIS database was performed to evaluate factors associated with kyphosis maintenance. A total of 526 patients were enrolled in the database and had a mean thoracic kyphosis (T5-T12) of 22 degrees . In total, 269 patients were identified who had kyphosis of less than 22 degrees and thus comprised the group to be included in this analysis. A complete radiographical series was obtained for each patient preoperatively, immediately postoperatively, and at 2 years postoperatively. All operative data, including the number of levels fused and implant type and density, were also recorded. Multivariate and regression analysis were performed. RESULTS.: Eight variables were found to be significantly correlated with kyphosis maintenance at 2 years postoperatively. Anterior approach (r = 0.37, P < 0.001), increased thoracic coronal curve (r = 0.20, P = 0.001), and a greater percentage of hooks in the construct (r = 0.18, P = 0.034) were associated with increased kyphosis at follow-up. A greater number of levels fused (r = -0.33, P < 0.001), preoperative kyphosis (r = -0.39, P < 0.001), percentage of screws in the construct (r = -0.18, P = 0.03), using standard stainless steel rods (r = -0.47, P = 0.011), and percent decrease in thoracic curve (r = -0.23, P < 0.001) all were correlated with hypokyphosis at follow-up. CONCLUSION.: Our multivariate analysis demonstrates that in patients with AIS who have thoracic hypokyphosis as part of their deformity, certain factors must be taken into account in the preoperative planning to prevent hypokyphosis after surgical correction.
PMID: 22228329
ISSN: 0362-2436
CID: 173973

Effects of obesity on pediatric fracture care and management

Lazar-Antman, Meredith A; Leet, Arabella I
Obese children have a theoretically increased risk of sustaining an extremity fracture because of potential variations in their bone mineral density, serum leptin levels, and altered balance and gait. Trauma databases suggest an increased rate of extremity fractures in obese children and adolescents involved in polytrauma compared with nonobese children and adolescents. Anesthetic and other perioperative concerns for obese pediatric trauma patients undergoing surgery include higher baseline blood pressures, increased rates of asthma, and obstructive sleep apnea. A child's weight must be considered when choosing the type of implant for fixation of pediatric femoral fractures. Fracture prevention strategies in obese pediatric patients consist of ensuring properly sized safety gear for both motor vehicles and sporting activities and implementing structured weight-loss programs.
PMID: 22552676
ISSN: 1535-1386
CID: 4485402

Treatment of SCFE in a healthy 5-year-old child: case report and review

Lazar, Meredith A; Van Gelderen, Jeffrey T; Chu, Alice
Slipped capital femoral epiphysis is a common adolescent hip disorder and when patients present at an age younger than 10 years, it is atypical and there is often some identifiable associated metabolic or endocrinologic abnormality. We present the case of a 5-year-old boy with idiopathic bilateral slipped capital femoral epiphysis. This patient underwent staged bilateral pinning in situ using a uniquely modified screw where the distal threads were machined-off for smooth fixation across the physis. The patient had an unremarkable postoperative course and showed evidence of remodeling and patent physes at 1-year follow-up
PMID: 20847702
ISSN: 1473-5865
CID: 134303

Obesity and its relationship with pelvic and lower-extremity orthopedic trauma

Lazar, Meredith A; Plocher, Elizabeth K; Egol, Kenneth A
Obesity has been increasing steadily in the US population over the past 50 years. In trauma patients, obesity is associated with higher morbidity and mortality. There are reported increases in the incidence of cardiovascular, pulmonary, venous thromboembolic, and infectious complications in obese trauma patients. Obese patients who sustain high-energy traumatic injuries often sustain orthopedic injuries to the pelvis or lower extremities. Obese orthopedic trauma patients may be at higher risk for nerve injuries secondary to positioning, intraoperative complications, loss of reduction after surgery, increased intraoperative estimated blood loss, and increased operative times. Orthopedic surgeons must be aware of these results when treating these fractures in obese trauma patients
PMID: 20512170
ISSN: 1934-3418
CID: 109854

Snapping scapula syndrome

Lazar, Meredith A; Kwon, Young W; Rokito, Andrew S
Snapping scapula syndrome arises from either a soft-tissue or a skeletal anomaly within the scapulothoracic space that creates a cracking sound during scapulothoracic motion that patients associate with pain. Nonoperative measures consisting of supervised physical therapy, anti-inflammatory medications, and therapeutic injections are the mainstay of treatment. Open, arthroscopic, and combined operative approaches have been described for the treatment of refractory cases, with good overall outcomes in many relatively small case series. However, the optimal operative approach has yet to be determined
PMID: 19724005
ISSN: 1535-1386
CID: 101965

Bilateral THA in a patient with Waldenstrom's macroglobulinemia [Case Report]

Lazar, Meredith A; Levine, Brett R; Steiner, German; Jaffe, William L
PMID: 17539216
ISSN: 0147-7447
CID: 73114