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Encapsulated anaplastic thyroid carcinoma transformed from follicular carcinoma: a case report [Case Report]

Rapkiewicz, Amy; Roses, Daniel; Goldenberg, Alec; Levine, Pascale; Bannan, Michael; Simsir, Aylin
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is rare but is one of the most aggressive and lethal human malignancies. Cytologically, ATC has a variable morphologic appearance, including squamoid, giant, spindled and pleomorphic cells. The coexistence of ATC and differentiated or poorly differentiated thyroid carcinoma has been described and usually is diagnosed when the disease is locally advanced. CASE: We describe a case of surgically resectable, encapsulated, well-circumscribed ATC occurring in association with a better differentiated follicular carcinoma diagnosed by fine needle aspiration in a patient exposed to external ionizing radiation. CONCLUSION: Encapsulated variants of anaplastic carcinoma can be seen in association with lower grade thyroid carcinoma such as follicular carcinoma. Accurate diagnosis is dependent on adequate sampling
PMID: 19534279
ISSN: 0001-5547
CID: 100202

Non-image guided fine needle aspiration of palpable axillary lymph nodes in breast cancer patients [Meeting Abstract]

Marti, JL; Ayo, D; Levine, P; Hernandez, O; Rescigno, J; Axelrod, DM
ISI:000262583200147
ISSN: 0008-5472
CID: 93514

Diagnosis of Schistosoma haematobium on voided urine cytology: a case report with radiologic correlation [Case Report]

Laser, Alice; Kacher, John; Amodio, John; Strubel, Naomi; Elgert, Paul; Levine, Pascale
BACKGROUND: Infection with schistosomal species is becoming a more frequent finding in hospitals throughout the United States. Some causes that can be attributed to the rise include increased immigration from and travel to endemic areas. CASE: We report a case of urinary schistosomiasis diagnosed on urine cytology in a 7-year-old Nigerian boy. Infection was suspected after review of the clinical history and correlation with radiologic images. CONCLUSION: The rise in incidence has made it necessary for cytopathologists to be increasingly aware of these infections, in particular, Schistosoma haematobium, because it is the most frequent agent to be encountered on a cytology specimen, particularly urine. Similar cases have been published, one with specimen concentration and one without. However, no cases of cytology diagnosis with radiologic correlation are seen in the English literature
PMID: 19248562
ISSN: 0001-5547
CID: 97785

Origin, frequency and clinical significance of glandular cells in liquid-based pap tests from patients posthysterectomy

Ramdall, Risha B; Wallach, Robert C; Cangiarella, Joan; Cai, Guoping; Elgert, Paul; Simsir, Aylin; Levine, Pascale
OBJECTIVE: To quantify the frequency and significance of glandular cells in posthysterectomy liquid-based (SurePath, TriPath Imaging, Burlington, North Carolina, U.S.A.) vaginal Pap tests. STUDY DESIGN: The presence of benign glandular cells in vaginal Pap tests from posthysterectomy patients represents a diagnostic challenge and may pose management issues. We investigated the presence, frequency and significance of glandular cells in 52 liquid-based (SurePath) vaginal Pap tests from posthysterectomy patients by combining cytomorphologic findings with adjunctive immunohistochemistry and mucin stains performed on cell block preparations and correlated the findings with clinical data. RESULTS: After performing these special studies, the frequency of reporting glandular cells in posthysterectomy Pap tests decreased from 3.5% to 1.2% of all vaginal Pap tests performed in a 6-month period. CONCLUSION: A strong association of the presence of benign appearing glandular cells and a previous history of gynecological malignancy (71%) and chemotherapy/radiation (59%) were noted, likely representing a regenerative process in response to injury or therapy
PMID: 19248548
ISSN: 0001-5547
CID: 94186

Fine-needle aspiration of metastatic prostatic neuroendocrine carcinomas: cytomorphologic and immunophenotypic features

Cai, Guoping; Ramdall, Risha B; Levine, Pascale; Yang, Grace C H
Metastatic prostatic carcinoma may, in rare occasions, present as a neuroendocrine tumor. Its recognition is crucial to avert a wrongful exclusion of prostate as a primary site. We report five cases of metastatic prostatic neuroendocrine carcinoma diagnosed by image-guided fine-needle aspiration biopsy. The aspirate smears showed loosely cohesive or dyscohesive clusters of tumor cells with scanty (three cases) to moderate amount (two cases) of cytoplasm, speckled or coarse chromatin and inconspicuous nucleoli. Nuclear molding and necrosis were focally present in two cases. Immunohistochemically, the tumor cells were positive for synaptophysin or/and chromogranin, but negative for prostatic specific antigen and prostatic specific acid phosphatase. Review of prior prostate biopsies/resections revealed adenocarcinoma with focal neuroendocrine differentiation in all cases, with two cases being newly recognized on retrospective review. Confirming neuroendocrine differentiation in the prior biopsy/resection may help to establish a link between metastasis and prostate primary
PMID: 18618716
ISSN: 1097-0339
CID: 81355

Diagnosis of myeloid sarcoma involving salivary glands by fine-needle aspiration cytology and flow cytometry: report of four cases [Case Report]

Cai, Guoping; Levine, Pascale; Sen, Filiz
Myeloid sarcoma involving salivary glands is extremely rare. Here, we report four cases of this rare occurrence, diagnosed by fine-needle aspiration biopsy. All of four patients had previous diagnoses of myeloid neoplasms. They presented with a solitary mass in the parotid or submandibular salivary gland. The cytological evaluation of the aspirates revealed scattered salivary gland acini admixed with dispersed atypical cells. In three cases, the atypical cells appeared to be heterogeneous, intermediate to large in size, and have folded nuclei with fine chromatin. In another case the atypical cells were monotonous and had round nuclei with fine chromatin. The myeloid lineage of the atypical cells was demonstrated by flow cytometric analysis. High clinical suspicion, careful cytological evaluation, and concurrent ancillary studies are essential for establishing a diagnosis of myeloid sarcoma
PMID: 18181186
ISSN: 8755-1039
CID: 76339

Inflammatory breast cancer pathogenesis is mediated in significant part by translation initiation factor eIF4G amplification and unorthodox protein synthesis [Meeting Abstract]

Silvera, D; Arju, R; Darvishian, F; Levine, PH; Formenli, SC; Schneider, RJ
ISI:000251398500048
ISSN: 0167-6806
CID: 75798

Spectrum of head and neck lesions diagnosed by fine-needle aspiration cytology in the pediatric population

Rapkiewicz, Amy; Thuy Le, Bich; Simsir, Aylin; Cangiarella, Joan; Levine, Pascale
Fine-needle aspiration cytology (FNAC) of the head and neck region is well accepted as a diagnostic procedure in the adult population. FNAC in the pediatric population is gaining acceptance as clinicians add this technique to the diagnostic armamentarium. An experience with FNAC of the head and neck region in the pediatric population is described from 2 large inner-city hospitals. Eighty-five cases were retrieved from patients age <18 years. In 52 cases, clinical or surgical follow-up was obtained and among these cases the specificity and sensitivity of FNA was 93% and 100%, respectively. The high specificity of FNAC allows the clinician to be confident of malignancy in a clinically suspicious lesion of the head and neck in a pediatric patient. Cancer (Cancer Cytopathol) 2007. (c) 2007 American Cancer Society.
PMID: 17554755
ISSN: 0008-543x
CID: 72983

Pulmonary metastasis of giant cell tumor of the bone diagnosed by fine-needle aspiration biopsy [Case Report]

Cai, Guoping; Ramdall, Risha; Garcia, Roberto; Levine, Pascale
Giant cell tumor is a benign but locally aggressive tumor that primarily affects the epiphyses of long bones of young adults. Pulmonary metastases in giant cell tumor are rare (about 1-9%). Here, we report a case of metastatic pulmonary giant cell tumor in a patient who had a previous history of giant cell tumor of the distal femur with multiple recurrences. The diagnosis of pulmonary metastasis was achieved by cytologic evaluation with concurrent immunohistochemical studies in material obtained by fine-needle aspiration biopsy. The aspirate smears contained clustered and dispersed mononuclear and osteoclast-like giant cells that had bland nuclei with inconspicuous nucleoli. All multinucleated cells showed immunoreactivity to KP-1 antibody, a histiocytic marker (not lineage specific) and only a subset of mononuclear cells (30%) stained with this marker. Twenty percent of the mononuclear cells also displayed increased Ki-67 and p53 protein expression. The pulmonary metastasis was similar morphologically and immunophenotypically to the recurrent giant cell tumor of the bone. Diagn. Cytopathol. 2007;35:358-362. (c) 2007 Wiley-Liss, Inc.
PMID: 17497658
ISSN: 8755-1039
CID: 72750

Intraparenchymal leiomyoma of the breast: a case report and review of the literature [Case Report]

Ende, Lauren; Mercado, Cecilia; Axelrod, Deborah; Darvishian, Farbod; Levine, Pascale; Cangiarella, Joan
We report a case of an intraparenchymal leiomyoma of the breast with description of the radiologic, histopathologic, and immunohistochemical findings. To the best of our knowledge, this is the first case of an intraparenchymal leiomyoma of the breast diagnosed by core needle biopsy and the 22nd case described in the literature. In addition, we review the literature on this uncommon breast neoplasm
PMID: 17709693
ISSN: 0091-7370
CID: 73878