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Non-autoimmune hyperthyroidism caused by a somatic mosaic GNAS gene mutation involving part of the thyroid gland

Franca, Monica M; Levine, Robert L; Pappa, Theodora; Ilaka-Chibuluzo, Sandra; Rothberger, Gary D; Dumitrescu, Alexandra M; Refetoff, Samuel
Non-autoimmune hyperthyroidism caused by activating mutations in the GNAS gene is a rare condition. Here we report a 5-year-old girl diagnosed with non-autoimmune hyperthyroidism and tall stature harboring a somatic mosaic gain-of-function mutation in the GNAS gene (NM_080425.3: c.2530C>T;p.Arg844Cys previously reported as NM_000516.5:c.601C>T;p.Arg201Cys) and referred thereafter as R201C, in three of four quadrants of the thyroid gland. Provision of a molecular diagnosis may avoid unnecessary complete ablation of the thyroid gland.
PMID: 31910104
ISSN: 1557-9077
CID: 4294852

An evaluation of a 'BE NICE Champion' program: A bullying intervention program for registered nurses

Keller, Ronald; Allie, Tammy; Levine, Robert
AIM/OBJECTIVE:To explore the experiences, perceptions, and attitudes of registered nurses (RNs) who completed the BE NICE Champion training program; a home-grown program that provides RNs tools to intervene when bullying is observed; using the -4S's-: Stand-by, Support, Speak up, and Sequester. BACKGROUND:The growing body of literature surrounding the negative impact bullying has on individuals and organizations suggests the need to develop more effective prevention and intervention programs. METHOD/METHODS:A qualitative focus group approach utilizing a purposive sample of 25 RNs who participated in the training program. RESULTS:Three consistent themes emerged from a content analysis of the transcripts: (a) awareness and understanding, (b) applying the 4S's, and (c) feeling prepared and empowered. Additional themes included: impact on the work environment and additional program recommendations tailored to nursing leadership. IMPLICATIONS FOR NURSING MANAGEMENT/CONCLUSIONS:Leaders need to demonstrate a commitment to address bullying. Implementing this program can positively impact their environment. CONCLUSION/CONCLUSIONS:The program and use of the 4S's adequately provided RNs with confidence to intervene when bullying was observed. RNs felt better equipped to respond due to the techniques learned and appreciated our organizational commitment to address bullying. Furthermore, the program may be strengthened by incorporating recommendations discussed.
PMID: 30615232
ISSN: 1365-2834
CID: 3579802