Faculty Bibliography

We aimed to determine whether a unique, ultra-high-field 7 T magnetic resonance imaging (MRI) scanner could detect occult cartilage and meniscal injuries in asymptomatic female dancers. This study had Institutional Review Board approval. We recruited eight pre-professional female dancers and nine non-athletic, female controls. We scanned the dominant knee on a 7 T MRI scanner using a three-dimensional fast low-angle shot sequence and a proton density, fast spin-echo sequence to evaluate cartilage and menisci, respectively. Two radiologists scored cartilage (International Cartilage Repair Society classification) and meniscal (Stoller classification) lesions. We applied two-tailed z- and t-tests to determine statistical significance. There were no cartilage lesions in dancers or controls. For the medial meniscus, the dancers demonstrated higher mean MRI score (2.38 +/- 0.61 vs 1.0 +/- 0.97, P < 0.0001) and higher frequency of mean grade 2 lesions (88% vs 11%, P < 0.01) compared with the controls. For the lateral meniscus, there was no difference in score (0.5 +/- 0.81 vs 0.5 +/- 0.78, P = 0.78) in dancers compared with the control groups. Asymptomatic dancers demonstrate occult medial meniscal lesions. Because this has been described in early osteoarthritis, close surveillance of dancers' knee symptoms and function with appropriate activity modification may help maintain their long-term knee health.

BACKGROUND: Fatigue is strongly linked to an increased risk of injuries, including anterior cruciate ligament (ACL) ruptures. Part 1 of this study identified differences in the biomechanics of landing from a jump between dancers and team athletes, particularly female athletes, which may explain the epidemiological differences in ACL injuries between dancers and team athletes and the lack of a sex disparity within dancers. However, it is not known if these biomechanical variables change differently between team athletes and dancers in the face of fatigue. PURPOSE/ HYPOTHESIS: The purpose of this study was to compare dancers' and team athletes' resistance to fatigue and its effect on the biomechanics of single-legged drop landings. The primary hypotheses were that dancers may be more resistant than team athletes to the onset of fatigue and/or may have different biomechanical responses than athletes in landing tasks once fatigue has been achieved. STUDY DESIGN: Controlled laboratory study. METHODS: Kinematics and kinetics were recorded as 40 elite modern and ballet dancers (20 men and 20 women) and 40 team sport athletes (20 men and 20 women; National Collegiate Athletic Association Division I-III) performed single-legged drop landings from a 30-cm platform before and after a fatigue protocol consisting of step-ups and vertical jumps. Unfatigued and fatigued joint kinematics and kinetics were compared between groups and sexes with multivariate analyses of variance, followed by pairwise t tests as appropriate. RESULTS: Dancers took longer (P = .023) than team athletes to reach a similar state of fatigue. Multiple kinetic (eg, increased peak knee valgus moment; P < .001) and kinematic (eg, increased lateral and forward trunk flexion; P < .001 and P = .002, respectively) parameters of landing changed with fatigue, such that both fatigued dancers and athletes landed with mechanics that were more at risk for ACL injuries as compared with before fatigue. CONCLUSION: Dancers took significantly longer to reach fatigue than team athletes. Female athletes consistently exhibited landing patterns associated with a risk for ACL injuries when compared with the other 3 groups. Fatigue changed landing mechanics similarly in both dancers and athletes, such that all groups landed with worse alignment after being fatigued. CLINICAL RELEVANCE: Dancers are more resistant to lower extremity fatigue than athletes, and this may partially explain the lower incidence of ACL injuries in both male and female dancers compared to team athletes. The extensive training in landing technique and daily practice that dancers undergo from a young age may be responsible for the higher levels of endurance.

BACKGROUND: The incidence of anterior cruciate ligament (ACL) injuries among dancers is much lower than among team sport athletes, and no clear disparity between sexes has been reported in the dance population. Although numerous studies have observed differences in landing biomechanics of the lower extremity between male and female team sport athletes, there is currently little research examining the landing biomechanics of male and female dancers and none comparing athletes to dancers. Comparing the landing biomechanics within these populations may help explain the lower overall ACL injury rates and lack of sex disparity. HYPOTHESIS: The purpose was to compare the effects of sex and group (dancer vs team sport athlete) on single-legged drop-landing biomechanics. The primary hypothesis was that female dancers would perform a drop-landing task without demonstrating typical sex-related risk factors associated with ACL injuries. A secondary hypothesis was that female team sport athletes would display typical ACL risk factors during the same task. STUDY DESIGN: Controlled laboratory study. METHODS: Kinematics and kinetics were recorded as 40 elite modern and ballet dancers (20 men and 20 women) and 40 team sport athletes (20 men and 20 women) performed single-legged drop landings from a 30-cm platform. Joint kinematics and kinetics were compared between groups and sexes with a group-by-sex multivariate analysis of variance (MANOVA) followed by pairwise t tests. RESULTS: Dancers of both sexes and male team sport athletes landed similarly in terms of frontal-plane knee alignment, whereas female team sport athletes landed with a significantly greater peak knee valgus (P = .007). Female dancers were found to have a lower hip adduction torque than those of the other 3 groups (P = .003). Dancers (male and female) exhibited a lower trunk side flexion (P = .002) and lower trunk forward flexion (P = .032) compared with team sport athletes. CONCLUSION: In executing a 30-cm drop landing, female team sport athletes displayed a greater knee valgus than did the other 3 groups. Dancers exhibited better trunk stability than did athletes. CLINICAL RELEVANCE: These biomechanical findings may provide insight into the cause of the epidemiological differences in ACL injuries between dancers and athletes and the lack of a sex disparity within dancers.

Despite its widespread and long term use, the effectiveness of iontophoresis to increase the delivery of dexamethasone sodium phosphate (DSP) remains controversial. The goal of this study was to quantitatively compare the DSP concentrations in dermis' dialysates in two delivery scenarios: with and without iontophoresis. Interstitial fluid concentrations were measured by cutaneous microdialysis. Passive and active iontophoresis were applied simultaneously on the skin of the forearm in eight healthy adult participants using each participant as his/her own control. The iontophoresis apparatus and procedures were identical to those used in common clinical practice. Iontophoresis electrodes were loaded with 2 mL of 4.4 mg/mL of preservative-free DSP solution. Electric current (4 mA) was applied for 20 min. Dialysate samples were collected for 2 h and analyzed for DSP and its active metabolite dexamethasone (DXM). Seven out of eight iontophoresis sites contained quantifiable levels of DSP and DXM, whereas none of the samples collected at the passive site contained either form of the drug. In conclusion, this study demonstrates that iontophoresis significantly (p < 0.0001) increases delivery of DSP to the dermis compared with passive delivery of the same, and that microdialysis can be used to monitor DSP delivery and DXM formation in skin. (c) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:191-196, 2014.