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Removing geographic boundaries from liver allocation: A method for designing continuous distribution scores

Mankowski, Michal A; Wood, Nicholas L; Segev, Dorry L; Gentry, Sommer E
BACKGROUND:The Organ Procurement and Transplantation Network (OPTN) is eliminating geographic boundaries in liver allocation, in favor of continuous distribution. Continuous distribution allocates organs via a composite allocation score (CAS): a weighted sum of attributes like medical urgency, candidate biology, and placement efficiency. The opportunity this change represents, to include new variables and features for prioritizing candidates, will require lengthy and contentious discussions to establish community consensus. Continuous distribution could instead be implemented rapidly by computationally translating the allocation priorities for pediatric, status 1, and O/B blood type liver candidates that are presently implemented via geographic boundaries into points and weights in a CAS. METHODS:Using simulation with optimization, we designed a CAS that is minimally disruptive to existing prioritizations, and that eliminates geographic boundaries and minimizes waitlist deaths without harming vulnerable populations. RESULTS:Compared with Acuity Circles (AC) in a 3-year simulation, our optimized CAS decreased deaths from 7771.2 to 7678.8 while decreasing average (272.66 NM vs. 264.30 NM) and median (201.14 NM vs. 186.49 NM) travel distances. Our CAS increased travel only for high MELD and status 1 candidates (423.24 NM vs. 298.74 NM), and reduced travel for other candidates (198.98 NM vs. 250.09 NM); overall travel burden decreased. CONCLUSION/CONCLUSIONS:Our CAS reduced waitlist deaths by sending livers for high-MELD and status 1 candidates farther, while keeping livers for lower MELD candidates nearby. This advanced computational method can be applied again after wider discussions of adding new priorities conclude; our method designs score weightings to achieve any specified feasible allocation outcomes.
PMID: 37204074
ISSN: 1399-0012
CID: 5486532

Designing Continuous Distribution for Liver Allocation [Meeting Abstract]

Mankowski, Michal; Wood, Nicholas; Segev, Dorry; Gentry, Sommer
ISI:000739470700008
ISSN: 1600-6135
CID: 5133502

Successful Transplantation of cPRA 95 to 100% HLA Incompatible (HLA I) KPD Candidates: A new combined Strategy at a Single Centre [Meeting Abstract]

Al Meshari, Khalid; Broering, Dieter; Alahmadi, Ibrahim; Ali, Tariq; Alzayer, Fadi; Mankowski, Michal; Algharabl, Amal
ISI:000739470700023
ISSN: 1600-6135
CID: 5456232

Prevalence of anti-SARS-CoV-2 antibody in hemodialysis facilities: a cross-sectional multicenter study from Madinah

Housawi, Abdulrahman A; Qazi, Shazada Junaid S; Jan, Abdulhalem A; Osman, Rashid A; Alshamrani, Mashil M; AlFaadhel, Talal A; AlHejaili, Fayez F; Al-Tawfiq, Jaffar A; Wafa, Ahmed A; Hamza, Abdulmageed E; Hassan, Moustafa A; Alharbi, Suliman A; Albasheer, Hamza; Almohmmdi, Majed M; Alsisi, Salem A; Mankowski, Michal; Van de Klundert, Joris; Alhelal, Amal M; Sala, Fatima H; Kheyami, Ali; Alhomayeed, Bader A
BACKGROUND:Since the occurrence of coronavirus disease in 2019 (COVID-19), the global community has witnessed its exponential spread with devastating outcomes within the general population and specifically within hemodialysis patients. OBJECTIVES/OBJECTIVE:Compare the state of immunity to SARS-CoV-2 among hemodialysis patients and staff. DESIGN/METHODS:Cross-sectional study with a prospective follow-up period. SETTING/METHODS:Hemodialysis centers in Madinah region. PATIENTS AND METHODS/METHODS:We prospectively tested for SARS-CoV-2 antibodies in dialysis patients using dialysis centers staff as controls. The participants were tested on four occasions when feasible for the presence of anti-SARS-CoV-2 antibodies. We also analyzed factors that might be associated with seropositivity. MAIN OUTCOME MEASURES/METHODS:SARS-CoV-2 positivity using immunoglobulin G (IgG) levels SAMPLE SIZE: 830 participants, 677 patients and 153 dialysis centers staff as controls. RESULTS:<.0001). Surprisingly, positivity was also center-dependent. In a multivariable logistic regression, a history of infection and related symptoms contributed significantly to developing immunity. CONCLUSION/CONCLUSIONS:The high prevalence of SARS-CoV-2 antibody among hemodialysis patients and previously asymptomatic staff suggested past asymptomatic infection. Some centers showed more immunity effects than others. LIMITATIONS/CONCLUSIONS:Unable to collect four samples for each participant; limited to one urban center. CONFLICT OF INTEREST/BACKGROUND:None.
PMCID:9357293
PMID: 35933611
ISSN: 0975-4466
CID: 5456122

Designing Continuous Distribution for Liver Allocation. [Meeting Abstract]

Mankowski, M.; Wood, N.; Segev, D.; Gentry, S.
ISI:000842606302312
ISSN: 1600-6135
CID: 5486642

Kidney paired donation in Brazil - a single center perspective [Letter]

Bastos, Juliana; Mankowski, Michal; E Gentry, Sommer; Massie, Allan; Levan, Macey; Bisi, Cellen; Stopato, Carlos; Freesz, Thais; Colares, Vinícius; L Segev, Dorry; Ferreira, Gustavo
PMID: 34028104
ISSN: 1432-2277
CID: 5150312

Kidney Exchange Program Reporting Standards: Evidence-Based Consensus From Europe

Smeulders, Bart; Mankowski, Michal A; van de Klundert, Joris
PMCID:7928410
PMID: 33681134
ISSN: 2296-2565
CID: 5456112

Kidney Exchange Program Reporting Standards: Evidence-Based Consensus From Europe

Smeulders, Bart; Mankowski, Michal A.; van de Klundert, Joris
ISI:000621353100001
ISSN: 2296-2565
CID: 5456222

When One Size Does Not Fit All: Geographically Heterogeneous Liver Distribution [Meeting Abstract]

Mankowski, M. A.; Gentry, S.; Segev, D.; Trichakis, N.
ISI:000705310103116
ISSN: 1600-6135
CID: 5486632

Dynamic programming multi-objective combinatorial optimization

Mankowski, Michal; Moshkov, Mikhail
Cham, Switzerland : Springer, 2021
ISBN: 9783030639204
CID: 5486672