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Type 2 autoimmune pancreatitis: case report of a 9-year-old female and a review of the literature [Case Report]

Patel, Zinal; Patel, Suril; Grendell, James; Marciano, Tuvia
We report a case of autoimmune pancreatitis in a 9-year-old female who presented with persistent epigastric pain for 3 weeks. Magnetic resonance cholangiopancreatography (MRCP) showed both intrahepatic and extrahepatic biliary ductal dilatation. The common bile duct, along with the pancreatic duct, was noted to be dilated. Labs showed normal IgG and IgG4 levels and negative for autoimmune antibodies. Endoscopic ultrasound revealed the pancreatic head to be enlarged and surrounded by hypoechoic and lobulated lymph nodes. Biopsy of the pancreatic head showed chronic mildly active inflammation with fibrosis, acinar atrophy, and lymphocytic infiltrate. A diagnosis of autoimmune pancreatitis (AIP) was made, and she was treated with prednisone. The patient's symptoms improved quickly, and follow-up MRCP showed resolution of inflammatory changes and intrahepatic and pancreatic ductal dilatation.
PMID: 26590828
ISSN: 1865-7265
CID: 3411982

Autoimmune Pancreatitis: Case Report of a 9-Year-Old Female and Review of Literature [Meeting Abstract]

Patel, Zinal; Patel, Suril; Chapalamadugu, Prateek; Marciano, Tuvia; Husain, Sohil; Grendell, James
ISSN: 0002-9270
CID: 3537922

The ontogeny and developmental physiology of gastric acid secretion

Marciano, Tuvia; Wershil, Barry K
The production of acid by the stomach is a tightly controlled physiological process that involves neural and hormonal mechanisms and the input of several epithelial cell types. The past several years have seen significant advances in our understanding of the molecular ontogenesis of the stomach and the factors controlling stomach innervation, as well as the differentiation of gastric epithelial cell lineages and their respective hormones/factors that influence acid production. The programmed development of each of these elements is exquisitely regulated and allows human neonates to produce gastric acid; it also helps us define expectations of acid production in preterm infants at all gestational ages.
PMID: 18377799
ISSN: 1534-312x
CID: 3537882

Pneumatic dilation with a 35 mm balloon, a safe and effective initial therapy in pediatric achalasia [Meeting Abstract]

Novak, Inna; Marciano, Tuvia; Guerin, Theresa; Rivas, Yolanda
ISSN: 0002-9270
CID: 3537912

Carbon dioxide, a safe insufflation agent in pediatric endoscopy [Meeting Abstract]

Marciano, Tuvia; Guerin, Theresa; Cohen, Susan; Rivas, Yolanda
ISSN: 0016-5107
CID: 3537902

Low-dose acyclovir for HSV-2 meningitis in a child [Case Report]

Kohlhoff, S A; Marciano, T A; Rawstron, S A
A 7-y-old girl with genital herpes following sexual abuse presented with dysuria, fever and meningeal signs. Acyclovir (15 mg/kg/d for 10 d) was administered for severe genitourinary symptoms. The CSF culture was positive for HSV type 2. Complete resolution of all symptoms demonstrates that, as in adults, HSV-2 meningitis does not require high-dose or prolonged acyclovir therapy.
PMID: 15456207
ISSN: 0803-5253
CID: 3537892