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Successful Implementation of Healthful Nutrition Initiatives into Hospitals

Aggarwal, Monica; Grady, Ariel; Desai, Daya; Hartog, Katrina; Correa, Lilian; Ostfeld, Robert J; Freeman, Andrew M; McMacken, Michelle; Gianos, Eugenia; Reddy, Koushik; Batiste, Columbus; Wenger, Christopher; Blankstein, Ron; Williams, Kim; Allen, Kathleen; Seifried, Rebecca M; Barnard, Neal D
Poor dietary quality is a leading contributor to mortality in the United States and to most cardiovascular risk factors. By providing education on lifestyle changes and specifically, dietary changes, hospitals have the opportunity to use the patient experience as a "teachable moment." The food options provided to inpatients and outpatients can be a paradigm for patients to follow upon discharge from the hospital. There are hospitals in the United States that are showcasing novel ways to increase awareness of optimal dietary patterns and can serve as a model for hospitals nationwide.
PMID: 31494109
ISSN: 1555-7162
CID: 4087382

Ketogenic Diets for Diabetes and Obesity-Reply

Joshi, Shivam; Ostfeld, Robert J; McMacken, Michelle
PMID: 31790534
ISSN: 2168-6114
CID: 4249812

The Ketogenic Diet for Obesity and Diabetes-Enthusiasm Outpaces Evidence

Joshi, Shivam; Ostfeld, Robert J; McMacken, Michelle
PMID: 31305866
ISSN: 2168-6114
CID: 3977632

Utility of Unrefined Carbohydrates in Type 2 Diabetes. Comment on "Reversing Type 2 Diabetes: A Narrative Review of the Evidence, Nutrients, 2019, 11, 766"

Joshi, Shivam; Zaki, Timothy; Ostfeld, Robert J; McMacken, Michelle
Hallberg et al. provide a limited literature review on the reversal of type 2 diabetes mellitus (T2DM) [...].
PMID: 31319611
ISSN: 2072-6643
CID: 3978032

A plant-based diet for the prevention and treatment of type 2 diabetes

McMacken, Michelle; Shah, Sapana
The prevalence of type 2 diabetes is rising worldwide, especially in older adults. Diet and lifestyle, particularly plant-based diets, are effective tools for type 2 diabetes prevention and management. Plant-based diets are eating patterns that emphasize legumes, whole grains, vegetables, fruits, nuts, and seeds and discourage most or all animal products. Cohort studies strongly support the role of plant-based diets, and food and nutrient components of plant-based diets, in reducing the risk of type 2 diabetes. Evidence from observational and interventional studies demonstrates the benefits of plant-based diets in treating type 2 diabetes and reducing key diabetes-related macrovascular and microvascular complications. Optimal macronutrient ratios for preventing and treating type 2 diabetes are controversial; the focus should instead be on eating patterns and actual foods. However, the evidence does suggest that the type and source of carbohydrate (unrefined versus refined), fats (monounsaturated and polyunsaturated versus saturated and trans), and protein (plant versus animal) play a major role in the prevention and management of type 2 diabetes. Multiple potential mechanisms underlie the benefits of a plant-based diet in ameliorating insulin resistance, including promotion of a healthy body weight, increases in fiber and phytonutrients, food-microbiome interactions, and decreases in saturated fat, advanced glycation endproducts, nitrosamines, and heme iron.
PMID: 28630614
ISSN: 1671-5411
CID: 2604232

Randomized Pilot Trial of Bariatric Surgery Versus Intensive Medical Weight Management on Diabetes Remission in Type 2 Diabetic Patients Who Do NOT Meet NIH Criteria for Surgery and the Role of Soluble RAGE as a Novel Biomarker of Success

Parikh, Manish; Chung, Mimi; Sheth, Sheetal; McMacken, Michelle; Zahra, Tasneem; Saunders, John K; Ude-Welcome, Aku; Dunn, Van; Ogedegbe, Gbenga; Schmidt, Ann Marie; Pachter, H Leon
OBJECTIVE: To compare bariatric surgery versus intensive medical weight management (MWM) in patients with type 2 diabetes mellitus (T2DM) who do not meet current National Institutes of Health criteria for bariatric surgery and to assess whether the soluble form of receptor for advanced glycation end products (sRAGE) is a biomarker to identify patients most likely to benefit from surgery. BACKGROUND: There are few studies comparing surgery to MWM for patients with T2DM and BMI less than 35. METHODS: Fifty-seven patients with T2DM and BMI 30 to 35, who otherwise met the criteria for bariatric surgery were randomized to MWM versus surgery (bypass, sleeve or band, based on patient preference). The primary outcomes assessed at 6 months were change in homeostatic model of insulin resistance (HOMA-IR) and diabetes remission. Secondary outcomes included changes in HbA1c, weight, and sRAGE. RESULTS: The surgery group had improved HOMA-IR (-4.6 vs +1.6; P = 0.0004) and higher diabetes remission (65% vs 0%, P < 0.0001) than the MWM group at 6 months. Compared to MWM, the surgery group had lower HbA1c (6.2 vs 7.8, P = 0.002), lower fasting glucose (99.5 vs 157; P = 0.0068), and fewer T2DM medication requirements (20% vs 88%; P < 0.0001) at 6 months. The surgery group lost more weight (7. vs 1.0 BMI decrease, P < 0.0001). Higher baseline sRAGE was associated with better weight loss outcomes (r = -0.641; P = 0.046). There were no mortalities. CONCLUSIONS: Surgery was very effective short-term in patients with T2DM and BMI 30 to 35. Baseline sRAGE may predict patients most likely to benefit from surgery. These findings need to be confirmed with larger ID: NCT01423877.
PMID: 25203878
ISSN: 0003-4932
CID: 1186772

Tuberculous prostate abscesses in an immunocompetent patient: A dramatic presentation of disseminated tuberculosis

Johnson, Matthew G; Caplan-Shaw, Caralee E; McMacken, Michelle
Genitourinary tuberculosis (TB) is infrequently reported in the United States, but is a common form of extrapulmonary TB that often goes unnoticed due to its insidious and sometimes asymptomatic presentation. Prostate involvement and the development of tuberculous prostatic abscesses have been reported in the literature largely in association with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). We report a case of disseminated TB involving tuberculous prostatic abscesses in a patient without HIV/AIDS, presenting with sepsis and urinary symptoms. This patient had simultaneous prostatic, peritoneal, pulmonary, and likely renal TB, serving as a reminder to clinicians that multi-organ presentations of TB do occur in patients without overt immunosuppressive conditions. This case also highlights the importance of considering the diagnosis of genitourinary TB in patients with risk factors for TB presenting with vague, long-standing urinary symptoms.
PMID: 24967218
ISSN: 2248-2997
CID: 1051312

A structured weight management program for obese patients in an urban safety-net hospital center

Chapter by: McMacken, Michelle; Moore, Sarah; Randlett, Diana; Parikh, Lisa
in: Obesity interventions in underserved communities: Evidence and directions by Brennan, Virginia M; Kumanyika, Shiriki K; Zambrana, Ruth Enid [Eds]
Baltimore, MD : Johns Hopkins University Press; US, 2014
pp. 353-361
ISBN: 1-4214-1545-3
CID: 1522462

Role of Bariatric Surgery as Treatment for Type 2 Diabetes in Patients Who Do Not Meet Current NIH Criteria: A Systematic Review and Meta-Analysis

Parikh, Manish; Issa, Reda; Vieira, Dorice; McMacken, Michelle; Saunders, John K; Ude-Welcome, Aku; Schubart, Ulrich; Ogedegbe, Gbenga; Pachter, H Leon
PMID: 23890843
ISSN: 1072-7515
CID: 512922


Weerahandi, Himali; Patterson, Elenore; Ahn, Albert; Deza, Camila; Parikh, Lisa; Pierre, Gaelle C; Gillespie, Colleen; McMacken, Michelle
ISSN: 1525-1497
CID: 2782342