Try a new search

Format these results:

Searched for:



Total Results:


Wounds in Patients with HIV

McMeeking, Alexander; Kim, In; Ross, Frank; Ayello, Elizabeth A; Brem, Harold; Linton, Patrick; O'Neill, Daniel K
Highly active antiretroviral therapy has dramatically reduced morbidity and mortality among patients who are HIV-positive. A retrospective review of the authors' data separated subjects into cohorts based on HIV status and matched them for age and gender. The authors' data reveal a higher fraction of venous ulcers compared with a lower fraction of pressure ulcers in the seropositive population.
PMID: 25133341
ISSN: 1527-7941
CID: 1132102

A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma

Stone, T; Berger, A; Blumberg, S; O'Neill, D; Ross, F; McMeeking, A; Chen, W; Pastar, I
Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.
PMID: 22099725
ISSN: 1742-4801
CID: 159112

Acute renal failure after initiation of tenofovir disoproxil fumarate [Case Report]

Hynes, Peter; Urbina, Antonio; McMeeking, Alexander; Barisoni, Laura; Rabenou, Rahmin
Despite initial evidence suggesting a relatively benign safety profile, several subsequent case reports have detailed nephrotoxicity in patients using tenofovir disoproxil fumarate for the treatment of HIV. We report a case of rapid renal failure that developed into an HIV-naive patient initiated on an antiretroviral regimen that included tenofovir
PMID: 18067059
ISSN: 0886-022x
CID: 76336

Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing [Case Report]

Bruno, G R; Howland, M A; McMeeking, A; Hoffman, R S
Ingestion of long-acting anticoagulant rodenticides such as brodifacoum can lead to prolonged and life-threatening coagulopathy. A paucity of conflicting information is available on brodifacoum's half-life and elimination pharmacokinetics. In addition, the optimal dose, duration, and route of administration of vitamin K(1) therapy are unknown. We report the case of a 52-year-old man who ingested eight 43-g boxes of a rodenticide (d-Con Mouse-Prufe II; 0.005% brodifacoum; Reckitt & Colman, Wayne, NJ). This case demonstrates that after stabilization with fresh frozen plasma, high-dose oral vitamin K(1) therapy ( congruent with 7 mg/kg per 24 hours divided every 6 hours) was effective in treating brodifacoum-induced coagulopathy. The concentration of vitamin K(1) required for normal coagulation in this case was less than the accepted value of 1 microg/mL, which is derived from a rabbit model. In this case, brodifacoum appears to follow zero-order elimination pharmacokinetics. In future cases of patients with ingestions of long-acting anticoagulants who present with coagulopathy, it may be useful to obtain serial brodifacoum concentrations to determine elimination curves to help predict the duration of oral vitamin K(1) therapy
PMID: 10969235
ISSN: 0196-0644
CID: 112795

Thallium-201 uptake in cytomegalovirus encephalitis [Case Report]

Gorniak RJ; Kramer EL; McMeeking AA; Zagzag D
A 36-yr-old man with AIDS exhibited intense 201Tl uptake (lesion-to-brain uptake ratio 5.38) in a brain lesion previously detected by MRI and CT. The lesion was biopsied and found to contain cells with viral inclusions diagnostic of cytomegalovirus infection, not tumor as the thallium SPECT results suggested. Thallium-201 SPECT may be less specific than previously reported for differentiating neoplastic disease from opportunistic infections in AIDS patients
PMID: 9293794
ISSN: 0161-5505
CID: 9351

Cytomegalovirus disease presenting as a focal brain mass: report of two cases [Case Report]

Huang PP; McMeeking AA; Stempien MJ; Zagzag D
OBJECTIVE AND IMPORTANCE: Although the differential diagnosis of intracranial lesions in patients who have tested positive for human immunodeficiency virus is extensive, toxoplasmosis, lymphoma, and progressive multifocal leukoencephalopathy comprise approximately 90% of such cases. Cytomegalovirus infection of the central nervous system may be difficult to diagnose and rarely presents as mass lesions revealed by radiographic studies. CLINICAL PRESENTATION: Two patients who had tested positive for human immunodeficiency virus presented with progressive focal neurological deficits. Radiographic studies revealed solitary contrast-enhancing lesions in the right basal ganglia and right cerebellar hemisphere, respectively. INTERVENTION: The first patient underwent a stereotactic biopsy but died despite appropriate therapy. The second patient died without tissue having been obtained for diagnosis. Postmortem examinations revealed necrotizing lesions with diffuse areas of infiltrating histiocytes containing eosinophilic cytomegalovirus inclusion bodies. CONCLUSION: Although rare, cytomegalovirus infection should be considered in patients who have tested positive for human immunodeficiency virus and who present with enhancing intracranial lesions
PMID: 9149268
ISSN: 0148-396x
CID: 56954

Babesiosis in a patient with sickle cell anemia [Case Report]

Klein P; McMeeking A; Goldenberg A
PMID: 9217625
ISSN: 0002-9343
CID: 7181

Cryptococcal choroiditis in a patient with AIDS: case report and review [Case Report]

Gandhi SA; McMeeking AA; Friedberg D; Holzman RS
PMID: 8922837
ISSN: 1058-4838
CID: 12495

Phase I/II study of PIXY321 for HIV related pancytopenia [Meeting Abstract]

Goldenberg, A; McMeeking, A; Cao, YZ; Garrison, L
ISSN: 0006-4971
CID: 53125

Actinomyces infection of a cytomegalovirus esophageal ulcer in two patients with acquired immunodeficiency syndrome [Case Report]

Poles MA; McMeeking AA; Scholes JV; Dieterich DT
Esophageal disease is a significant cause of morbidity among patients with the acquired immunodeficiency syndrome (AIDS). Many organisms have been implicated in the pathogenesis of dysphagia and odynophagia. We describe a unique presentation of actinomyces esophageal infection in two homosexual male patients with AIDS and biopsy proven CMV esophagitis. After failure of esophagitis to resolve with ganciclovir or foscarnet therapy, the patients underwent repeat endoscopy and were subsequently found to have a secondary infection of the ulcers by Actinomyces. Treatment with intravenous penicillin G resulted in symptomatic and histopathological resolution of esophageal disease. This appears to be the first report of Actinomyces infection of esophageal ulcers in AIDS patients, possibly a commonly overlooked diagnosis
PMID: 8079942
ISSN: 0002-9270
CID: 12895