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34


Unclassified Renal Cell Carcinoma: Diagnostic and Molecular Updates [Review]

Mirsadraei, Leili; Chen, Ying-Bei
Unclassified renal cell carcinoma is a diagnostic category for renal cell tumors not fitting into one of the established subtypes in our current classification system and includes a heterogeneous group of tumors with variable clinicopathologic features and biological behaviors. Unclassified renal cell carcinoma with high-grade histologic features represents a particularly challenging group of tumors for diagnosis and management, given their complex pathologic features, aggressive clinical attributes, and a lack of standard therapy. Using an example case of high-grade unclassified renal cell carcinoma, this review discusses the diagnostic approaches to these tumors in the context of the World Health Organization 2016 classification system and provides updates on the molecular characteristics of these tumors.
ISI:000424294200006
ISSN: 2381-5949
CID: 3584022

Evaluation of Histological Changes in Radical Prostatectomy (RP) After Neoadjuvant Androgen Deprivation Therapy (NeoADT): Comparison Between Conventional and Newer Therapy Regimens [Meeting Abstract]

Huang, Kuo-Cheng; Mirsadraei, Leili; Chen, Ying-Bei; Sirintrapun, Joseph S.; Al-Ahmadie, Hikmat; Fine, Samson W.; Touijer, Karim A.; Eastham, James; Autio, Karen A.; Rathkopf, Dana E.; Tickoo, Satish K.; Scher, Howard I.; Reuter, Victor E.; Gopalan, Anuradha
ISI:000393724401209
ISSN: 0023-6837
CID: 3583942

Comparative Analysis of Histopathology Assessment Criteria to Predict Progression in PT1 Bladder Cancer [Meeting Abstract]

Leivo, Mariah Z.; Sahoo, Debashis; Mirsadraei, Leili; Hansel, Donna
ISI:000393724401234
ISSN: 0023-6837
CID: 3583952

Morphologic, Clinical and Molecular Features of Large Cell Neuroendocrine Carcinoma (LCNEC) of the Bladder [Meeting Abstract]

Mirsadraei, Leili; Hao, Xueli; Teo, Min-Yuen; Huang, Kuo-Cheng; Chen, Ying-Bei; Gopalan, Anuradha; Sirintrapun, Joe; Fine, Samson W.; Tickoo, Satish K.; Bochner, Bernard H.; Dalbagni, Guido; Bajorin, Dean F.; Taylor, Barry S.; Solit, David; Iyer, Gopakumar V.; Reuter, Victor E.; Al-Ahmadie, Hikmat
ISI:000393724401259
ISSN: 0023-6837
CID: 3583962

Evaluation of Histological Changes in Radical Prostatectomy (RP) After Neoadjuvant Androgen Deprivation Therapy (NeoADT): Comparison Between Conventional and Newer Therapy Regimens [Meeting Abstract]

Huang, Kuo-Cheng; Mirsadraei, Leili; Chen, Ying-Bei; Sirintrapun, Joseph S.; Al-Ahmadie, Hikmat; Fine, Samson W.; Touijer, Karim A.; Eastham, James; Autio, Karen A.; Rathkopf, Dana E.; Tickoo, Satish K.; Scher, Howard I.; Reuter, Victor E.; Gopalan, Anuradha
ISI:000394467301209
ISSN: 0893-3952
CID: 3583972

Comparative Analysis of Histopathology Assessment Criteria to Predict Progression in PT1 Bladder Cancer [Meeting Abstract]

Leivo, Mariah Z.; Sahoo, Debashis; Mirsadraei, Leili; Hansel, Donna
ISI:000394467301234
ISSN: 0893-3952
CID: 3583982

Morphologic, Clinical and Molecular Features of Large Cell Neuroendocrine Carcinoma (LCNEC) of the Bladder [Meeting Abstract]

Mirsadraei, Leili; Hao, Xueli; Teo, Min-Yuen; Huang, Kuo-Cheng; Chen, Ying-Bei; Gopalan, Anuradha; Sirintrapun, Joe; Fine, Samson W.; Tickoo, Satish K.; Bochner, Bernard H.; Dalbagni, Guido; Bajorin, Dean F.; Taylor, Barry S.; Solit, David; Iyer, Gopakumar V.; Reuter, Victor E.; Al-Ahmadie, Hikmat
ISI:000394467301259
ISSN: 0893-3952
CID: 3583992

Comparative Evaluation of the Paris Reporting System for Urine Cytology with Our Original Urine Cytology Reporting System [Meeting Abstract]

Yekezare, Somaye; Mirsadraei, Leili; Liao, Xiaoyan; Reisian, Niloufar; Shabaik, Ahmed; Hasteh, Farnaz
ISI:000369270700479
ISSN: 0023-6837
CID: 3583922

Comparative Evaluation of the Paris Reporting System for Urine Cytology with Our Original Urine Cytology Reporting System [Meeting Abstract]

Yekezare, Somaye; Mirsadraei, Leili; Liao, Xiaoyan; Reisian, Niloufar; Shabaik, Ahmed; Hasteh, Farnaz
ISI:000370302500479
ISSN: 0893-3952
CID: 3583932

Nitroxoline induces apoptosis and slows glioma growth in vivo

Lazovic, Jelena; Guo, Lea; Nakashima, Jonathan; Mirsadraei, Leili; Yong, William; Kim, Hyun J; Ellingson, Benjamin; Wu, Hong; Pope, Whitney B
BACKGROUND:Nitroxoline is an FDA-approved antibiotic with potential antitumor activity. Here we evaluated whether nitroxoline has antiproliferative properties on glioma cell growth in vitro and in vivo using glioma cell lines and a genetically engineered PTEN/KRAS mouse glioma model. METHODS:The effect of nitroxoline treatment on U87 and/or U251 glioma cell proliferation, cell-cycle arrest, invasion, and ability to induce an apoptotic cascade was determined in vitro. Magnetic resonance imaging was used to measure glioma volumes in genetically engineered PTEN/KRAS mice prior to and after nitroxoline therapy. Induction of apoptosis by nitroxoline was evaluated at the end of treatment using terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling (TUNEL). RESULTS:Nitroxoline inhibited the proliferation and invasion of glioblastoma cells in a time- and dose-dependent manner in vitro. Growth inhibition was associated with cell-cycle arrest in G1/G0 phase and induction of apoptosis via caspase 3 and cleaved poly(ADP-ribose) polymerase. In vivo, nitroxoline-treated mice had no increase in tumor volume after 14 days of treatment, whereas tumor volumes doubled in control mice. Histological examination revealed 15%-20% TUNEL-positive cells in nitroxoline-treated mice, compared with ∼5% in the control group. CONCLUSION/CONCLUSIONS:Nitroxoline induces apoptosis and inhibits glioma growth in vivo and in vitro. As an already FDA-approved treatment for urinary tract infections with a known safety profile, nitroxoline could move quickly into clinical trials pending confirmatory studies.
PMCID:4483047
PMID: 25074541
ISSN: 1523-5866
CID: 3584152