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Reopening During the Unprecedented: The Association of Biomolecular Resource Facilities Community Coronavirus Disease 2019 Pandemic Response. Part 2: Efforts to Effectively Ramp Up Core Facility Activities

Rappoport, Joshua Z; Larsen, DeLaine D; Abrams, Benjamin; Vinard, Andrew; Kigenyi, Justine; Girard, Isabelle; White, A Nicole; Porter, Desiree M; Mische, Sheenah M
Shared research resources, also known as core facilities, serve a crucial role in supporting research, training, and other needs for their respective institutions. In response to the coronavirus disease (COVID-19) pandemic, all but the most critical laboratory research was halted in many institutions around the world. The Association of Biomolecular Resource Facilities conducted 2 surveys to understand and document institutional responses to the COVID-19 pandemic from core facility perspectives. The first survey was focused on initial pandemic response and efforts to sustainably ramp down core facility operations. The second survey, which is the subject of this study, focused on understanding the approaches taken to ramp up core facility operations after these ramp-down procedures. The survey results revealed that many cores remained active during the ramp-down, performing essential COVID-19 research, and had a more coordinated institutional response for ramping up research as a whole. The lessons gained from this survey will be indexed to serve as a resource for the core facility community to understand, plan, and mitigate risk and disruptions in the event of future disasters.
PMID: 35837270
ISSN: 1943-4731
CID: 5278492

Establishing a national strategy for shared research resources in biomedical sciences

Charalambakis, Naomi E; Ambulos, Nicholas P; Hockberger, Philip; Meyn, Susan M; Bowen, Sara K; Constable, Susan; Fisher, Nancy C; Fletcher, Luellen; Kigenyi, Justine; Mundoma, Claudius; Ramirez-Aguilar, Kathryn A; Vinard, Andrew; Winn, Mary E; Mische, Sheenah M
Contemporary science has become increasingly multi-disciplinary and team-based, resulting in unprecedented growth in biomedical innovation and technology over the last several decades. Collaborative research efforts have enabled investigators to respond to the demands of an increasingly complex 21st century landscape, including pressing scientific challenges such as the COVID-19 pandemic. A major contributing factor to the success of team science is the mobilization of core facilities and shared research resources (SRRs), the scientific instrumentation and expertise that exist within research organizations that enable widespread access to advanced technologies for trainees, faculty, and staff. For over 40 years, SRRs have played a key role in accelerating biomedical research discoveries, yet a national strategy that addresses how to leverage these resources to enhance team science and achieve shared scientific goals is noticeably absent. We believe a national strategy for biomedical SRRs-led by the National Institutes of Health-is crucial to advance key national initiatives, enable long-term research efficiency, and provide a solid foundation for the next generation of scientists.
PMID: 34624149
ISSN: 1530-6860
CID: 5039752

SRLs in a Global Pandemic: An Administrative Perspective [Editorial]

Auger, Julie; Fletcher, Luellen; Frankowiak, Shawn; Grills, George; Lemas, M Victor; Mische, Sheenah; Monteiro, Marta; Peláez, Fernando; Tabarini, Diane; Vinard, Andrew; White, A Nicole
PMID: 33188580
ISSN: 1552-4930
CID: 5122712

Preparing for the Unprecedented: The Association of Biomolecular Resource Facilities (ABRF) Community Coronavirus Disease 2019 (COVID-19) Pandemic Response Part 1: Efforts to Sustainably Ramp Down Core Facility Activities

Kigenyi, Justine; Mische, Sheenah M; Porter, Desiree M; Rappoport, Joshua Z; Vinard, Andrew
The coronavirus disease 2019 (COVID-19) pandemic has curtailed all but the most critical laboratory research in many institutions around the world. These unplanned and unprecedented operational changes have put considerable stress on every aspect of the research enterprise, from funding agencies to research institutes, individual and core laboratories, researchers, and research administrators, with drastic changes in demands and deliverables. The Association of Biomolecular Resource Facilities Core Administrators Network Coordinating Committee initiated a forum-wide discussion followed by a global survey to gain information on how institutions and, specifically, shared resource core facilities were responding to the COVID-19 pandemic. The survey aimed to identify shared resource core facility challenges and opportunities related to operational ramp downs, shutdowns, or research "pauses" during the COVID-19 pandemic, as well as new practices and resources needed to ensure business continuity. Although a number of positive outcomes from remote work hold promise for improved core operations, the survey results revealed a surprising level of unfamiliarity with business continuity planning for cores and limited coordination within institutions. Recommendations for business continuity planning include key stakeholders working together to assess risk, prioritize work, and promote transparency across campus.
PMID: 32999636
ISSN: 1943-4731
CID: 4617012

The abrf 2020 meeting: Empowering team science

Mische, Sheenah M.; Cole, Richard; Mason, Christopher E.; Weintraub, Susan E.; White, A. Nicole
The Association of Bimolecular Resource Facilities (ABRF) annual meeting was held in Palm Springs, California, USA on February 29-March 2, 2020. With 860 in attendance, the conference program featured five satellite workshops, one eminent scientist talk, four keynote talks, 24 sessions, 2 poster sessions, and fourteen technology showcases. The theme of the meeting "Empowering Team Science" encompassed bench to bedside, including extraterrestrial microbes, single cell "˜omics, multi "™omics, quantitative imaging, multidisciplinary research, shared resource management and precision medicine. Presentations on technology and applications for genomics, proteomics, metabolomics, bioinformatics, imaging and cytometry based multidisciplinary research from shared resource core laboratories continues to be the focus of the conference. Highlighted this year were the ABRF Research Groups and studies designed and analyzed to inform scientific rigor in research performed across multi institutional academic, government and industry laboratories.
ISSN: 1524-0215
CID: 4580572

Puerto Rico-INBRE Metabolomics Research Core

Chorna, Nataliya; Cadilla, Carmen; Medina, Jose Rodriguez; Mische, Sheenah; White, Nicole; Weis-Garcia, Frances
The PR-INBRE Metabolomics Research Core (MRC) is located at the University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. The MRC is the only facility of this kind in Puerto Rico available as a shared resource free-of-charge for undergraduate, graduate students, faculty members from INBRE Network universities and beyond who are interested in collaboration with the MRC in the development of new technologies that applied metabolomics approach in Neuroscience, Molecular Medicine, Drug Development, Environmental and Behavioral Sciences. The MRC is also available as a shared resource on a fee-for-service basis for other investigators, industrial laboratories, and clinics. The MRC offers a diverse applications of metabolomics technology for studying and answering biomedical questions related to basic and translational research by offering a scientific seminars and training workshops, support in the developing and optimizing methods for targeted and untargeted detection and quantification of various metabolites ranging from amino acids, organic acids, vitamins, phosphates, sugars, polyamines, alcohols, fatty acids, and sterols using diverse biological matrices including tissues, cells, and biofluids (urine, blood, saliva) via gas chromatography/mass spectrometry. The MRC operates to ensure the best practices and analytical performance of the existed state-of-art instrumentation Shimadzu GC/MS QP2010 and TQ8050 GC/MS/MS. The MRC has established collaborations with other IDeA cores such as the University of Vermont Mass Spectrometry Core and Montana State University Proteomics, Metabolomics and Mass Spectrometry Facility and continue nurturing new and expanding established collaborations with the other investigators and Core facilities. The long-term goal of the MRC is to accelerate the competitiveness of investigators by providing translational research strengths to their discoveries. The MRC is supported by the PR-INBRE (NIGMS P20 GM103475).
PMID: 32831667
ISSN: 1943-4731
CID: 4586802

A Review of the Scientific Rigor, Reproducibility, and Transparency Studies Conducted by the ABRF Research Groups

Mische, Sheenah M; Fisher, Nancy C; Meyn, Susan M; Church, Katia Sol; Hegstad-Davies, Rebecca L; Weis-Garcia, Frances; Adams, Marie; Ashton, John M; Delventhal, Kym M; Dragon, Julie A; Holmes, Laura; Jagtap, Pratik; Mason, Christopher E; Palmblad, Magnus; Searle, Brian C; Turck, Christoph W; Knudtson, Kevin L
Shared research resource facilities, also known as core laboratories (Cores), are responsible for generating a significant and growing portion of the research data in academic biomedical research institutions. Cores represent a central repository for institutional knowledge management, with deep expertise in the strengths and limitations of technology and its applications. They inherently support transparency and scientific reproducibility by protecting against cognitive bias in research design and data analysis, and thedy have institutional responsibility for the conduct of research (research ethics, regulatory compliance, and financial accountability) performed in their Cores. The Association of Biomolecular Resource Facilities (ABRF) is a FASEB-member scientific society whose members are scientists and administrators that manage or support Cores. The ABRF Research Groups (RGs), representing expertise for an array of cutting-edge and established technology platforms, perform multicenter research studies to determine and communicate best practices and community-based standards. This review provides a summary of the contributions of the ABRF RGs to promote scientific rigor and reproducibility in Cores from the published literature, ABRF meetings, and ABRF RGs communications.
PMID: 31969795
ISSN: 1943-4731
CID: 4273212

Leadership in Science

White, A N; Mische, S; Winn, M
Modern science is teamwork. Leadership is a role, not a position, that can be used to motivate a team to achieve a common goal. Leadership in science encompasses the ability to empower a diverse team and create an inclusive culture that provides supportive energy and commitment so everyone can contribute their best. Put simply, the collective mindset of an organization shapes its culture and performance. We each bring to this collective mindset a set of assumptions, a perspective, methods, or notations. Everyone operates somewhere along a continuum from an inward to outward mindset. Our position on that continuum profoundly affects our performance, influence, and individual effectiveness. In this session we will present best practices for scientific leadership, what makes a leader great, and how one transitions from a manager to a leader that supports and encourages a diverse research community. We will: Define social structures and the importance of knowing social boundaries and perspectives; Define mindset, and understand the impact of inward vs outward focus; Identify the difference between social (role) strain and social (role) conflict; Understand the impact unconscious bias can have on our daily social roles; Develop awareness on how understanding mindset and social roles can help us to be better leader.
ISSN: 1943-4731
CID: 4259942

Rigor and Reproducibility in Shared Resources: ABRF Committee on Core Rigor and Reproducibility Survey Update

Knudtson, Kevin L; Hegstad-Davies, Rebecca L; Fisher, Nancy C; Hicks, Belynda; Meyn, Susan M; Mische, Sheenah M; Sol-Church, Katia; Weis-Garcia, Frances
Shared scientific resources, also known as core facilities, support a significant portion of the research pursued in biomolecular research institutions. The Committee on Core Rigor and Reproducibility (CCoRRe) conducted a survey aimed at the scientific core community to gaininformation on how NIH initiatives on advancing scientific rigor and reproducibility have influenced current services and new technology development in shared scientific resources.In addition, the survey aimed to identify the challenges and opportunities scientific cores have related to implementation of new reporting requirements to identify new practices and resources needed to assure rigorous research. Presented is a rigorous re-analysis of the participants' responses and commentaries. Results revealed mixed perspectives and levels of awareness regarding the NIH guidelines. Many of the perceived challenges to the effective implementation of scientific rigor and reproducibility practices were similarly noted as challenge areas in effectively providing support services in a core setting. Further, most cores routinely use best practices and offer services that support rigor and reproducibility. These factors include access to well-maintained instrumentation, training on experimental design and data analysis, as well as data management. Feedback from the survey will enable the ABRF to build better educational resources and share critical best practice guidelines. ABRF sponsors a central information portal that can be expanded to provide timely information on meetings, training modules, online repositories and webinars supporting research integrity. These resources will provide important tools to the core community and the researchers they serve to positively impact rigor and transparency across the range of science and technology.
PMID: 31892904
ISSN: 1943-4731
CID: 4251452

Research Community Action Post FASEB Report on Maximizing the Value of Shared Research Resources

Kigenyi, Justine Karungi; Auger, Julie; Stemke, Katherine Hale; Girard, Isabelle; Hugh, Tom; Meyn, Susan; Winn, Mary; Vinard, Andrew; Richards, Heather; Mische, Sheenah
In 2017 the Federation of American Societies for Experimental Biology (FASEB) published a report on maximizing the value of Shared Research Resources. In its report, FASEB made recommendations on a wide range of topics including; improving funding and business operations of shared resource laboratories, increasing discoverability and access, ensuring rigor and reproducibility, and keeping technology and scientific expertise up-to-date to meet evolving research needs. The report was very well-received by the shared research resources community. During this Open Mic session, participants will discuss and share with the ABRF community what their institutions or core facilities are doing in response to the recommendations of the FASEB report. These might include new policies, strategies or initiatives adopted in response to the recommendations of the report, or new thinking and approaches to pre-existing policies, strategies, initiatives or processes.
ISSN: 1943-4731
CID: 4354262