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Comparison of allergEAZE Allergens to Chemotechnique Diagnostics Allergens in the Evaluation of Contact Allergy

Yagerman, Sarah; Gruson, Lisa Moed; Brancaccio, Ronald R
PMID: 23169217
ISSN: 1710-3568
CID: 185002

Necrobiosis lipoidica [Case Report]

O'Reilly, Kathryn; Chu, Julie; Meehan, Shane; Heller, Patricia; Ashinoff, Robin; Gruson, Lisa
A 58-year-old woman presented with a seven-year history of an eruption on her lower legs that was associated with edema, weeping, pruritus, and a burning sensation. Past medical history included Hashimoto thyroiditis, which was diagnosed eight years prior to presentation. Histopathologic examination was consistent with necrobiosis lipoidica (NL). To our knowledge, NL that is associated with Hashimoto thyroiditis has been described in only one prior report. NL is a chronic, cutaneous, granulomatous condition with degenerative connective-tissue changes of unknown etiology. Our patient responded well to a potent topical glucocorticoid and topical tretinoin. Although our patient did not have diabetes mellitus, 75 percent of patients with NL have diabetes mellitus at the time of diagnosis or will subsequently develop diabetes mellitus. This association with diabetes mellitus mandates screening for glucose intolerance in all patients with NL.
PMID: 22031644
ISSN: 1087-2108
CID: 601032

Facial follicular porokeratosis: a case report

Wang, Nadia S; Gruson, Lisa M; Kamino, Hideko
Porokeratosis is a disorder of keratinization, characterized clinically by a peripheral keratotic ridge and histologically by the cornoid lamella. We describe a patient with follicular porokeratosis with a distinctive clinical presentation. We believe that follicular porokeratosis is a unique histopathologic variant of porokeratosis, with cornoid lamellae centered in follicular infundibula. Further, this is the only report of follicular porokeratosis involving the face exclusively
PMID: 20559115
ISSN: 1533-0311
CID: 112547

A case of hermansky-pudlak syndrome with pulmonary sarcoidosis

Gruson, Lisa; Berk, Thomas
Hermansky-Pudlak syndrome is an autosomal recessive disorder of lysosomal storage characterized by the triad of occulocutaneous albinism, bleeding diathesis, and pulmonary fibrosis. Sarcoidosis is a disease characterized by the development of noncaseating granulomas, most commonly affecting the lungs. The pathophysiology, histological findings, clinical symptoms, and treatment of the pulmonary manifestations of Hermansky-Pudlak syndrome are distinct from those of sarcoidosis. As patients with occulocutaneous and bleeding manifestations of Hermansky-Pudlak syndrome may also develop pulmonary fibrosis, the authors present this case to illustrate that pulmonary symptoms must be carefully evaluated in those with this syndrome because in this case, the patient developed underlying pulmonary sarcoidosis. To the authors' knowledge, this is the first documented case of Hermansky-Pudlak syndrome with concomitant pulmonary sarcoidosis
PMID: 20725574
ISSN: 1941-2789
CID: 111974

Lymphedema praecox [Case Report]

Rizzo, Carina; Gruson, Lisa M; Wainwright, Brent D
A 57-year-old man presented with the post-pubertal onset of asymptomatic swelling of the left arm and legs that had been complicated by recurrent bouts of cellulitis. The presentation and disease course are consistent with lymphedema praecox, which is a subtype of primary lymphedema with onset at puberty and a slowly progressive course. The subtypes of lymphedema, pathogenesis, and treatment are reviewed.
PMID: 19891915
ISSN: 1087-2108
CID: 933632

Mycosis fungoides involving the nasal mucosa [Letter]

Gruson, Lisa M; Heller, Patricia; Hemmerdinger, Steven A; Latkowski, Jo-Ann M
PMID: 17434033
ISSN: 1097-6787
CID: 72621

Reconsidering liver biopsies during methotrexate therapy [Letter]

Henning, Jeffery S; Gruson, Lisa M; Strober, Bruce E
PMID: 17437899
ISSN: 1097-6787
CID: 72620

Phacomatosis pigmentokeratotica associated with hemihypertrophy and a rhabdomyosarcoma of the abdominal wall [Case Report]

Gruson, Lisa M; Orlow, Seth J; Schaffer, Julie V
Phacomatosis pigmentokeratotica (PPK) represents a specific 'twin nevus' syndrome in which a speckled lentiginous nevus (SLN) is associated with an organoid nevus with sebaceous differentiation. A boy with a large nevus sebaceus on the left face and upper part of the trunk, a giant segmental SLN extending from the abdomen to the feet bilaterally, and right hemihypertrophy developed an embryonal rhabdomyosarcoma of the right abdominal wall at age 6 months. A variety of musculoskeletal, neurologic, and ocular anomalies have been observed in patients with PPK, reflecting the individual manifestations of both SLN and Schimmelpenning syndromes. This report adds hemihypertrophy to the spectrum of extracutaneous manifestations of PPK and, to our knowledge, represents the first observation of a rhabdomyosarcoma arising in contiguity with an SLN in a patient with PPK. The development of a rhabdomyosarcoma in our patient likely reflects both increased propensity for growth (as evidenced by the hemihypertrophy) and the pluripotent nature of neural-crest derived cells within the field defect that underlies an SLN
PMID: 16843117
ISSN: 1097-6787
CID: 67008

Diffuse large cell non-Hodgkin's lymphoma, CD30+, T-cell phenotype [Case Report]

Gruson, Lisa Moed; Latkowski, Jo-Ann
A 63-year-old Chinese man presented with an eczematous dermatitis that progressed into a multifocal nodular eruption. Histopathologic examination demonstrated a nodular and diffuse infiltrate in the reticular dermis, which was composed of lymphocytes, macrophages with granulomatous inflammation, and numerous eosinophils. Reactive lymphoid follicles with germinal centers also were present. Immunohistochemistry showed CD30 and LCA. ALK-1 and CD20 were negative. A diagnosis of CD30+ cutaneous T-cell lymphoma was made, and the patient is currently undergoing staging of his disease. Treatment options include excision of nodules, radiation therapy, and systemic chemotherapy
PMID: 16403389
ISSN: 1087-2108
CID: 66688

Scleredema and diabetic sclerodactyly [Case Report]

Gruson, Lisa Moed; Franks, Andrew Jr
A 40-year-old man presented with hardening of the skin of his hands and upper back, which had slowly worsened with time. His medical history included insulin-dependent diabetes mellitus since childhood. Histopathologic features of a biopsy specimen from the skin of his back showed a thick reticular dermis with collagen bundles in a haphazard array, which were separated by increased deposits of connective-tissue mucin. Scleredema and diabetic sclerodactyly are both well recognized skin findings that may occur in patients with diabetes mellitus. It is important to differentiate this condition from scleroderma. Treatment is difficult, and therefore many modalities have been used. This patient has improved with aminobenzoate, colchicine, and DMSO gel
PMID: 16403375
ISSN: 1087-2108
CID: 66679