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Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients

Monhian, Nathan; Jewett, Brian S; Baker, Shan R; Varani, James
OBJECTIVE:To obviate the difficulty of ruling out confounding variables (eg, age, individual variability) as the source of differences seen when comparing tumor tissue and control tissue from unrelated individuals, we examined the expression of matrix metalloproteinase (MMP)-1 (interstitial collagenase) and MMP-9 (92-kDa gelatinase B) in histologically normal skin immediately adjacent to basal cell carcinomas (peritumoral tissue) after Mohs micrographic surgery and postauricular skin from the same patients. DESIGN/METHODS:Peritumoral and postauricular skin samples were obtained from 17 patients undergoing Mohs surgery. Expression of MMP-1 and MMP-9 was examined in these specimens using a combination of approaches including zymography, collagen-degradation assays, and immunohistology. RESULTS:The expression levels of MMP-1 and MMP-9 were consistently elevated in the peritumoral tissue compared with skin from the distal site. CONCLUSION/CONCLUSIONS:This finding indicates that even when potentially important variables such as age and individual variability are controlled for, tumor-specific effects on the expression of MMP-9 and MMP-1 remain.
PMID: 16027344
ISSN: 1521-2491
CID: 5048482

A novel, conformable, rapidly setting nasal splint material: results of a prospective study

Ahn, Min S; Maas, Corey S; Monhian, Nathan
OBJECTIVE:To determine if a fiberglass splint material (3M Scotchcast, St Paul, Minn; Smith & Nephew, Inc, Charlotte, NC) serves as a better nasal cast than Aquaplast (Smith & Nephew, Inc) based on the criteria of total preparation time, ease of use, conformability, adhesion, and patient acceptability. DESIGN/METHODS:Prospective randomized comparison study with statistical analysis. SETTING/METHODS:University-based division of a facial plastic surgery private clinic. PATIENTS/METHODS:Sixteen consecutive patients desiring a functional and aesthetic improvement underwent open structure rhinoplasty with lateral osteotomies. No patients withdrew because of adverse effects. INTERVENTION/METHODS:Half of the patients were randomized to the study group (fiberglass splint material) and half to the control group (Aquaplast). Each patient was fitted with the appropriate casting material at the conclusion of the rhinoplasty procedure. Data were collected with respect to total preparation time, ease of use, conformability, and adhesion. Each patient was asked to evaluate the cast for level of comfort after 1 week. RESULTS:There were no significant differences between study groups for adhesion (P =.18) and conformability (P =.35). Patient acceptability was good or excellent in both study groups. The fiberglass splint material was significantly easier to use (P<.001) and required less total preparation time (P<.001). The mean total preparation time for the Aquaplast and fiberglass splint materials were, respectively, 7 minutes 32 seconds and 2 minutes 37 seconds. CONCLUSIONS:Compared with the commonly used nasal splinting material Aquaplast, fiberglass splint material is not significantly more adhesive, conformable, or comfortable for the patient. Fiberglass splint material is significantly easier to use and requires less total preparation time than Aquaplast. These differences may provide advantages in the immediate postoperative period and for the long-term success of rhinoplasty surgery.
PMID: 12633213
ISSN: 1521-2491
CID: 5048472

Pathology forum. Quiz case 1. Secondary syphilis [Case Report]

Monhian, N; Murr, A H; Mandpe, A H; Baehner, F L
PMID: 11177045
ISSN: 0886-4470
CID: 5048452

Total nasal reconstruction with alloplastic and autogenous grafts

Ahn, M S; Monhian, N; Maas, C S; Bikhazi, N B
The basic principles of successful total nasal reconstruction include providing a sufficient amount of tissue coverage, creating an adequate structural framework, and fashioning a viable inner lining. Relative uniformity of opinion exists regarding sources for tissue coverage and nasal lining. A variety of options exists, however, regarding the type of material used for nasal framework. Alloplastic metals, such as vitallium or titanium mesh, combined with autogenous soft tissue coverage, are reliable alternatives for use in total nasal reconstruction.
PMID: 11816204
ISSN: 0736-6825
CID: 5048462

Epithelioid sarcoma of the neck: a rare tumor mimicking metastatic carcinoma from an unknown primary [Case Report]

Kuhel, W I; Monhian, N; Shanahan, E M; Heier, L A
PMID: 9419151
ISSN: 0194-5998
CID: 417192

Implants in rhinoplasty

Maas, C S; Monhian, N; Shah, S B
A variety of materials have been employed in rhinoplasty for augmentation and reconstruction. While autogenous tissue remains the mainstay of nasal implants and are the clear choice for structural and augmentation grafting of the nasal tip, limited availability and unpredictable resorption or remodeling have made homologous and synthetic implants important considerations for dorsal augmentation grafting. This section discusses categories of graft materials, their physical properties, harvesting and preparation technique, and advantages and disadvantages. An algorithm for nasal implants for specific indications in support and augmentation is presented.
PMID: 9656882
ISSN: 0736-6825
CID: 5048492