Try a new search

Format these results:

Searched for:

person:nachtl02

in-biosketch:true

Total Results:

130


Achieving Menopausal Health Equity Network (AMEN): an educational intervention to improve OB/GYN knowledge of menopause-related racial and ethnic health disparities

Kalluru, Shilpa; Akande, Celine M; Bellon, Margot B; Mahendru, Nikhita; Jalili, Dona; Sampson, Amani; Goldstein, Steven R; Nachtigall, Margaret J; Nachtigall, Lila E; Dunham, Samantha M; Phillips, Kameelah A; Quinn, Gwendolyn P
OBJECTIVES/OBJECTIVE:To study the impact of an educational intervention on obstetrician-gynecologist clinicians' knowledge of racial and ethnic disparities in the menopause experience. METHODS:Twenty-five obstetrician-gynecologist physicians (residents, fellows, and attendings) at an academic medical center in New York, NY, completed the Achieving Menopausal Health Equity Network course, a brief web-based intervention consisting of four modules delivered through narrated didactic videos and interactive tools, a 10-item pretest and posttest, and a course evaluation survey. The primary outcome was a change in knowledge scores after the completion of the educational intervention. Item analysis was also performed to assess item discrimination, item difficulty, and response frequency. Feedback on modules was obtained, and thematic analysis was performed. RESULTS:In this study, 25 participants completed the educational intervention. There was a statistically significant increase in mean test scores after participation (pretest mean score=7.1/10 vs. posttest mean score=8.1/10, P =0.0021). The following themes emerged in thematic analysis: knowledge building with potential for practical application for clinicians and non-clinicians, clarity and relevance, and opportunities for growth for future iterations of the modules. CONCLUSIONS:This brief, online educational curriculum focused on racial and ethnic disparities in menopause significantly improved the knowledge of obstetrician-gynecologist clinicians at various levels of training and provides a useful model for introducing more formal training on menopause medicine for obstetrician-gynecologist clinicians.
PMID: 40327447
ISSN: 1530-0374
CID: 5839082

A randomized, pilot trial comparing vaginal hyaluronic acid to vaginal estrogen for the treatment of genitourinary syndrome of menopause

Agrawal, Surbhi; LaPier, Zoe; Nagpal, Shavy; Oot, Antoinette; Friedman, Steven; Hade, Erinn M; Nachtigall, Lila; Brucker, Benjamin M; Escobar, Christina
OBJECTIVE:The aim of this study was to compare the efficacy of a non-hormone alternative, vaginal hyaluronic acid (HLA), to a standard-of-care therapy, vaginal estrogen, for the treatment of genitourinary syndrome of menopause (GSM). METHODS:This was a randomized, parallel arm pilot trial. Women with GSM were randomized to an HLA vaginal suppository or vaginal estrogen cream for 12 wk to compare the primary outcome, the vulvovaginal symptom questionnaire (VSQ) score. Secondary outcomes included the following: the female sexual function index (FSFI), the vaginal symptom index (VSI), visual analog scale (VAS) for dyspareunia, vaginal itching, and vaginal dryness, patient global impression of improvement (PGI-I) at follow-up, vaginal maturation index, and vaginal pH. Differences between treatment groups were estimated using the two-sided, two-sample t -test and 95% confidence intervals. RESULTS:Forty-nine women were randomized and 45 participants (vaginal estrogen = 23, vaginal HLA = 22) provided data at week 12. Baseline characteristics were similar in both groups. On the VSQ, there was no observed difference in overall scores between the HLA and vaginal estrogen groups at 12 wk ( P = 0.81). Improvement was seen within both treatment groups on the VSQ after 12 wk. The VAS score, total VSI score, total FSFI score, and vaginal pH improved over time; however, improvement did not differ between study arms. Over 90% participants noted improvement on the PGI-I in both groups ( P = 0.61). No treatment-related serious adverse events occurred. CONCLUSIONS:There were no clinically meaningful differences between vaginal HLA and vaginal estrogen for the treatment of GSM after 12 wk. Vaginal HLA may be a promising non-hormone therapy for GSM.
PMID: 39042017
ISSN: 1530-0374
CID: 5679642

Update on estrogen therapy and prevention of bone loss [Comment]

Nachtigall, Margaret; Nachtigall, Lila
PMID: 37192835
ISSN: 1530-0374
CID: 5536542

Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons [Comment]

Nachtigall, Margaret; Nachtigall, Richard; Nachtigall, Lila
PMID: 36943220
ISSN: 1538-3598
CID: 5449142

Letter to the Editor [Comment]

Nachtigall, Margaret J; Nachtigall, Lila E; Nachtigall, Richard H
PMID: 33973542
ISSN: 1530-0374
CID: 4878322

Patient Satisfaction With the Use of Revaree to Treat Vaginal Atrophy Symptoms [Meeting Abstract]

Nachtigall, Lila; Sylla, Sarah; Veledar, Emir; Komorowski, James
ISI:000594858400101
ISSN: 1072-3714
CID: 4729422

Menopause and the gastrointestinal system: our gut feelings

Nachtigall, Lila E; Nachtigall, Lisa
PMID: 30839365
ISSN: 1530-0374
CID: 3724032

Cardiovascular health and the menopausal woman: the role of estrogen and when to begin and end hormone treatment

Naftolin, Frederick; Friedenthal, Jenna; Nachtigall, Richard; Nachtigall, Lila
Reports have correlated the use of estrogen for the treatment of menopausal symptoms with beneficial effects on the cardiovascular system. Molecular, biochemical, preclinical, and clinical studies have furnished a wealth of evidence in support of this outcome of estrogen action. The prospective randomized Women's Health Initiative (WHI) and the Early Versus Late Intervention Trial (ELITE) showed that starting menopausal hormone treatment (MHT) within 5 to 10 years of menopause is fundamental to the success of estrogen's cardioprotection in post-menopausal women without adverse effects. Age stratification of the WHI data has shown that starting hormone treatment within the first decade after menopause is both safe and effective, and the long-term WHI follow-up studies are supportive of cardioprotection. This is especially true in estrogen-treated women who underwent surgical menopause. A critique of the WHI and other relevant studies is presented, supporting that the timely use of estrogens protects against age- and hormone-related cardiovascular complications. Salutary long-term hormone treatment for menopausal symptoms and prevention of complications has been widely reported, but there are no prospective trials defining the correct length to continue MHT. At present, women undergoing premature menopause receive estrogen treatment (ET) until evidence of hormone-related complications intervenes. Normal women started on MHT who receive treatment for decades without hormone-related complications have been reported, and the WHI follow-up studies are promising of long-term post-treatment cardioprotection. A prevention-based holistic approach is proposed for timely and continuing MHT/ET administration as part of the general management of the menopausal woman. But this should be undertaken only with scheduled, annual patient visits including evaluations of cardiovascular status. Because of the continued occurrence of reproductive cancers well into older ages, these visits should include genital and breast cancer screening.
PMCID:6733383
PMID: 31543950
ISSN: 2046-1402
CID: 4105312

Changes in an office practice of menopause in the last 25 years

Nachtigall, Lila
PMID: 29570561
ISSN: 1530-0374
CID: 3001572

Contemporary Hormonal Contraception and the Risk of Breast Cancer [Comment]

Nachtigall, Lila; Naftolin, Frederick; Keefe, David L
PMID: 29595938
ISSN: 1533-4406
CID: 3025942