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Mitral Leaflet Shortening as an Ancillary Procedure in Obstructive Hypertrophic Cardiomyopathy

Swistel, Daniel G; Massera, Daniele; Stepanovic, Alexandra; Adlestein, Elizabeth; Reuter, Maria; Wu, Woon; Scheinerman, Joshua A; Nampi, Robert; Paone, Darien; Kim, Bette; Sherrid, Mark V
BACKGROUND:Mitral leaflet elongation is common in hypertrophic cardiomyopathy (HCM), contributes to obstructive physiology, and presents a challenge to dual surgical goals of abolition of outflow gradients and mitral regurgitation. Anterior leaflet shortening, performed as an ancillary surgical procedure during myectomy, is controversial. METHODS:This was a retrospective study of all patients undergoing myectomy from 1/2010 to 3/2020 analyzing survival and echocardiographic results. We compared outcomes of patients treated with myectomy and concomitant mitral leaflet shortening with patients treated with myectomy alone. Over this time technique for mitral shortening evolved from anterior leaflet plication to residual leaflet excision (ReLex). RESULTS:Myectomy was performed on 416 patients age 57.5±13.6 years, 204 (49%) female. Average follow up was 5.4±2.8 years. Survival follow-up was complete in 415. Myectomy without valve replacement was performed in 332 patients, of whom 192 had mitral valve shortening (58%). Mitral leaflet plication was performed in 73, ReLex in 151 and both in 32. Hospital mortality for patients undergoing myectomy was 0.7%. At 8 years, cumulative survival was 95% for both myectomy plus leaflet shortening and myectomy alone groups, with no difference in survival between the two. There was no difference in survival between anterior leaflet plication and ReLex groups. Echocardiography 2.5 years after surgery showed a decrease in resting and provoked gradients, mitral regurgitation and left atrial volume and no difference in key variables between ancillary leaflet shortening and myectomy alone patients. CONCLUSIONS:These results affirm that mitral shortening may be an appropriate surgical judgment for selected patients.
PMID: 38518836
ISSN: 1552-6259
CID: 5640912

Surgical Aortic Valve Replacement in a Patient with Very Severe Chronic Obstructive Pulmonary Disease

Yeom, Richard; Gorgone, Michelle; Malinovic, Matea; Panzica, Peter; Maslow, Andrew; Augoustides, John G; Marchant, Bryan E; Fernando, Rohesh J; Nampi, Robert G; Pospishil, Liliya; Neuburger, Peter J
PMID: 37657996
ISSN: 1532-8422
CID: 5618132

Contemporary Practice of Echocardiography in Transcatheter Aortic Valve Replacement [Editorial]

Pospishil, Liliya; Nampi, Robert G; Neuburger, Peter J
PMID: 34366216
ISSN: 1532-8422
CID: 5006092

Anesthesiology Research Using Surgical Registries: Consider the Source [Editorial]

Nampi, Robert G; Law, Tina W; Neuburger, Peter J
PMID: 33268278
ISSN: 1532-8422
CID: 4694262

TAVR Versus SAVR for the Treatment of Aortic Stenosis: Do We Have a Clear Winner? [Editorial]

Nampi, Robert G; Pospishil, Liliya; Neuburger, Peter J
PMID: 32418828
ISSN: 1532-8422
CID: 4443692

On-pump intracardiac echocardiography during septal myectomy for hypertrophic cardiomyopathy

Williams, David M; Nampi, Robert G; Saric, Muhamed; Grossi, Eugene A; Sherrid, Mark V; Swistel, Daniel G
PMID: 34317753
ISSN: 2666-2507
CID: 4949552

Can complex mitral valve repair be performed with robotics? An institution's experience utilizing a dedicated team approach in 500 patients

Loulmet, Didier F; Ranganath, Neel K; Neuburger, Peter J; Nampiaparampil, Robert G; Galloway, Aubrey C; Grossi, Eugene A
OBJECTIVES/OBJECTIVE:The full potential of robotics has not been achieved in terms of addressing the most challenging mitral valve (MV) cases. We outline our technique and report our early results with totally endoscopic robotic MV repair in a wide range of pathologies. METHODS:From May 2011 to August 2017, a dedicated team attempted totally endoscopic robotic MV repair in 500 MV regurgitation patients. Repair complexity was scored in 3 categories. We analysed our sequential case experience by quartiles. RESULTS:Patient mean age was 60.8 years (range 18-88). Aetiologies included: degenerative 382 (76.4%), functional 37 (7.4%), inflammatory 22 (4.4%) and others 59 (11.8%). Mitral annular calcification was present in 64 (12.8%) cases. Simple MV repair (annuloplasty alone or with 1 leaflet segment repair) was performed in 240 (48%) patients, complex (repair involving more than 1 segment on the same leaflet) in 140 (28%) patients and most complex (bileaflet repair or mitral annular calcification excision with atrioventricular groove repair) in 120 (24%) patients. Concomitant procedures included: left appendage closure (94.8%), patent foramen ovale/atrial septal defect (PFO/ASD) closure (19.6%), cryoablation (19.4%), tricuspid repair (6.2%) or hybrid percutaneous coronary revascularization (7.8%). The overall repair rate was 99.4%, with 0.6% early mortality and 1.2% stroke rate (0.2% permanent neurological deficit). Case complexity increased with our experience. Despite an increase in aortic occlusion and perfusion times (median 86.5 and 125 min) and a slight decrease in operating room extubation rate (overall 64%), length of hospital stay (median 4 days) and 30-day readmission rate (overall 3.6%) were not affected by the progressive inclusion of more complex cases. CONCLUSIONS:Totally endoscopic robotic MV repair performed by a dedicated team allows one to address the entire spectrum of pathological complexity and provides consistent results.
PMID: 30753381
ISSN: 1873-734x
CID: 3656212

Totally endoscopic resection of an unsuspected recurrent pleural tumor in a patient undergoing robotic mitral and tricuspid valve repair [Meeting Abstract]

Ranganath, N K; Loulmet, D F; Sadhra, H S; Geraci, T C; Nampiaparampil, R G; Cerfolio, R J; Galloway, A C; Grossi, E A
Objective: A 75-year-old woman with New York Heart Association class II heart failure presented with severe mitral and tricuspid regurgitation. Eight years prior, the patient had a large right thoracotomy for resection of a pleural tumor. Our goal was to demonstrate a totally endoscopic resection of an unsuspected recurrent pleural tumor preceding concomitant mitral and tricuspid valve repair.
Method(s): After initially positioning the patient in the left decubitus position via a posterolateral approach, extensive adhesiolysis between the right lower lobe and the diaphragmrevealed a nonimaged 2- to 3-cmmass in the right lower lobe. Limited parenchymal resection was performed. The patient was repositioned in a supine position. Transesophageal echocardiography confirmed severe mitral regurgitation with moderate to severe tricuspid regurgitation. Five lateral thoracic ports were placed for the da Vinci Xi system. Cardiopulmonary bypass was instituted via femoral access with independent femoral and internal jugular venous lines. An endoballoon clamp was positioned with fluorescent guidance and antegrade del Nido cardioplegia was administered. Sondergaard's groove was opened, and the left atrial appendage was oversewn with 2 layers of polytetrafluoroethylene (PTFE) sutures. The mitral valve was nonmyxoid, inconsistent with Barlow's disease. Inspection confirmed mild prolapse of the anterior leaflet, numerous hypertrophied and calcified secondary chordae, and restriction of the posterior leaflet. Secondary chordae were excised below the A2-A3, P1-P2, and P2-P3 clefts. Small triangular excisions were performed at the A2-A3 and P1-P2 junctions, which were both reconstructed with a running PTFE suture. Hydrostatic testing revealed mild central insufficiency due to a lack of coaptation depth. Commissuroplasty was performed with a single PTFE suture, and the P2-P3 cleft was closed with a running PTFE suture. A 30-mmannuloplasty band was inserted. Final hydrostatic testing revealed excellent leaflet coaptation. The cavae were occluded with snares, and the tricuspid valve was exposed via a right atriotomy. A reduction tricuspid annuloplasty with a 26-mm band was performed. With the heart reperfused and the aortic root and left ventricle vented, the atriotomies were closed.
Result(s): Postoperative transesophageal echocardiography demonstrated preserved left ventricular function with trace mitral and tricuspid regurgitation. The patient was discharged on postoperative day 6. Final pathological analysis confirmed a completely resected benign solitary fibrous tumor.
Conclusion(s): A totally endoscopic approach to mitral and tricuspid valve repair can be performed safely and effectively in patients with a prior right thoracotomy
ISSN: 1559-0879
CID: 4001702

Totally endoscopic robotic mitral valve repair in a patient with severe pectus excavatum [Meeting Abstract]

Ranganath, N K; Loulmet, D F; Sadhra, H S; Neragi-Miandoab, S; Nampiaparampil, R G; Galloway, A C; Grossi, E A
Objective: A 63-year-old man with severe asymmetric pectus excavatum (Haller index 3.55) presented with New York Heart Association class I symptoms, severe mitral regurgitation due to flail posterior leaflet, and preserved left ventricular (LV) function. Our goalwas to demonstrate a totally endoscopic robotic-assisted mitral repair.
Patient(s): Intraoperative transesophageal echocardiography confirmed severe mitral regurgitation with an anteriorly directed jet due to prolapse of the middle scallop of the posterior leaflet. Four ports were placed in the right chest for the da Vinci Xi surgical system (working, camera, left and right instruments), and cardiopulmonary bypass was instituted via femoral access with arterial and long venous cannulae. While preparing the pericardium, we noted that the right pulmonary veins entered the left atrium leftward of the sternum. An endoclamp was positioned with fluorescent guidance, and antegrade Del Nido cardioplegia was administered. Sondergaard's groove was opened and the left atrial appendage was oversewn with 2 layers of polytetrafluoroethylene sutures. With intracorporeal guidance, a 5th port for an atrial retractor was positioned to the right of the sternum, verifying that it could reach deep enough into the left chest. Analysis of lesions demonstrated a flail P2 leaflet and a globally myxoid mitral valve consistent with Barlow's disease. Although a 0-angle scope provided sufficient visualization of the valve and subvalvular regions, intermittent conflict existed between the instruments and the posterior sternum. A triangular excision of P2 was performed; abnormal chordae were excised below P2, and the defect was closed with polytetrafluoroethylene sutures. A 36-mm posterior annuloplasty band was attached with interrupted 2-0 braided sutures, and hydrostatic testing revealed no residual regurgitation.While the patient was being rewarmed, the endoclamp balloon was deflated while the LV and root were vented. The heart spontaneously returned to sinus rhythm, and the patient was weaned from cardiopulmonary bypass without inotropic support. Postoperative transesophageal echocardiography demonstrated preserved LV function and no residual regurgitation or gradient. The patient was extubated in the operating room and discharged on postoperative day 2.
Conclusion(s): Severe pectus excavatum can make right chest approaches difficult, even in a totally endoscopic robotic approach, but the lack of chest wall disruption allows a speedy recovery
ISSN: 1559-0879
CID: 4001732

Intraoperative Two- and Three-Dimensional Transesophageal Echocardiography in Combined Myectomy-Mitral Operations for Hypertrophic Cardiomyopathy

Nampiaparampil, Robert G; Swistel, Daniel G; Schlame, Michael; Saric, Muhamed; Sherrid, Mark V
Transesophageal echocardiography is essential in guiding the surgical approach for patients with obstructive hypertrophic cardiomyopathy. Septal hypertrophy, elongated mitral valve leaflets, and abnormalities of the subvalvular apparatus are prominent features, all of which may contribute to left ventricular outflow tract obstruction. Surgery aims to alleviate the obstruction via an extended myectomy, often with an intervention on the mitral valve and subvalvular apparatus. The goal of intraoperative echocardiography is to assess the anatomic pathology and pathophysiology in order to achieve a safe intraoperative course and a successful repair. This guide summarizes the systematic evaluation of these patients to determine the best surgical plan.
PMID: 29502589
ISSN: 1097-6795
CID: 2974652