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Clinical course and outcomes in adults with co-occurring hypertrophic cardiomyopathy and hypertension: a scoping review protocol

Arabadjian, Milla; Nicolas, Barnaby; Montgomery, Sophie; Pleasure, Mitchell; Collins, Maxine; Reuter, Maria; Massera, Daniele; Shimbo, Daichi; Sherrid, Mark
INTRODUCTION:Hypertension affects 40%-60% of adults with hypertrophic cardiomyopathy (HCM), the most common inherited cardiac condition. It can be a diagnostic confounder for HCM, contributing to delayed diagnosis. Clinically, treatment of co-occurring hypertension and HCM poses challenges as first-line and second-line antihypertensive medications are often contraindicated in HCM. The clinical course in adults with hypertension and HCM is also not well understood, and studies examining patient outcomes in this population are equivocal. In this paper, we aim to outline the protocol of a scoping review, a type of literature review, to systematically synthesise existing knowledge on adults with co-occurring HCM and hypertension, highlighting knowledge and evidence gaps, and identifying future research directions to optimise outcomes in this population. METHODS AND ANALYSIS:This review is guided by Arksey and O'Malley's conceptual framework on conducting scoping reviews. We will search five electronic databases (PubMed, CINAHL, Scopus, Embase and Web of Science) and reference lists of publications to identify eligible articles focusing on medical therapy, clinical course or outcomes in adults with HCM and hypertension, between 2011 and 2023. Our search strategy and presentation of results will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Scoping Review guideline. First, two independent reviewers will screen articles, by title and abstract, followed by a full-text screen to identify eligible articles. Relevant data will be extracted and synthesised. ETHICS AND DISSEMINATION:Ethical approval is not required for this review as it is a secondary data collection of published articles and does not involve human subject participation. We will present results of this review at relevant professional conferences and patient-centred educational events. Results will be published in a peer-reviewed journal. TRIAL REGISTRATION NUMBER:
PMID: 37463810
ISSN: 2044-6055
CID: 5535662

The Complexity of Measuring the Impact of Books

Halevi, Gali; Nicolas, Barnaby; Bar-Ilan, Judit
ISSN: 1053-8801
CID: 5029572

"To improve health and health care, volume XVI : The Robert Wood Johnson Foundation anthology" [Book Review]

Nicolas, Barnaby
ISSN: 1521-0987
CID: 5029582

Altmetrics : new approach for evaluating research impact

Nicolas, Barnaby
ISSN: 0541-5489
CID: 5029612

"Production of hospice space : conceptualizing the space of caring and dying" [Book Review]

Nicolas, Barnaby
ISSN: 1521-0987
CID: 5029592

Reflecting our communities : Brooklyn College Library's internship program open doors and minds

Nagell, Kate; Evans, Beth; Nicolas, Barnaby
ISSN: 0002-9769
CID: 5029602