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36


Malignant lymphoma of the lower urinary tract: A single institutional experience

Hoskoppal, Deepthi; Ren, Qinghu; Huang, Hongying; Park, Kyung; Deng, Fang-Ming
Lymphoma of the urinary tract is relatively rare and comprises of < 5% of all primary extra nodal lymphoma. Diagnoses of these lesions at anearly stage is important as they can disseminate or transform into high grade lesion if there is a delay in the diagnoses. There are only few case series and case reports on the malignant lymphoma of the urinary tract. The aim of this study was to characterize lymphoma involving the urinary bladder and prostate. We retrospectively reviewed the clinical data and histologic findings of the malignant lymphoma involving urinary bladder and prostate at our institution. Lymphoma involving the lower urinary tract clinically presented with lower urinary tract symptoms and usually with concurrent associated urinary bladder cancer or prostatic cancer in our series. Lymphoma should be included in the differential diagnoses especially in patients with prior history of lymphoid disorders. There should be a high index of suspicion when there is any atypical lymphoid infiltrate in routine urinary bladder and prostate surgical specimens.
PMID: 35526304
ISSN: 1618-0631
CID: 5213972

Methylation Profiling of Papillary Renal Neoplasm with Reverse Polarity [Meeting Abstract]

Park, Kyung; Serrano, Jonathan; Tran, Ivy; Feng, Xiaojun; Chen, Fei; Vasudevaraja, Varshini; Mirsadraei, Leili; Snuderl, Matija; Deng, Fang-Ming
ISI:000770360201237
ISSN: 0023-6837
CID: 5208632

Methylation Profiling of Papillary Renal Neoplasm with Reverse Polarity [Meeting Abstract]

Park, Kyung; Serrano, Jonathan; Tran, Ivy; Feng, Xiaojun; Chen, Fei; Vasudevaraja, Varshini; Mirsadraei, Leili; Snuderl, Matija; Deng, Fang-Ming
ISI:000770361801237
ISSN: 0893-3952
CID: 5208642

Tubulopapillary Carcinoma of the Breast: A Distinct Morphologic Entity with Molecular and Immunohistochemical Analysis [Meeting Abstract]

Salama, Abeer; Schwartz, Christopher; Zhu, Kelsey; Vasudevaraja, Varshini; Serrano, Jonathan; Jour, George; Park, Kyung; Snuderl, Matija; Cotzia, Paolo; Darvishian, Farbod
ISI:000770360200172
ISSN: 0023-6837
CID: 5243152

Comparison of Fresh Cell Pellets and Cell Blocks for Genomic Profiling of Advanced Cancers in Pleural Effusion Specimens: Promising Preliminary Results from a Validation Study [Meeting Abstract]

Chen, Fei; Kim, Christine; Shen, Guomiao; Feng, Xiaojun; Jour, George; Cotzia, Paolo; Brandler, Tamar; Sun, Wei; Snuderl, Matija; Simsir, Aylin; Park, Kyung
ISI:000770360200230
ISSN: 0023-6837
CID: 5243162

Kidney Tumor Classifier Using Whole Genome Methylation Array [Meeting Abstract]

Park, Kyung; Serrano, Jonathan; Chen, Fei; Tran, Ivy; Vasudevaraja, Varshini; Hoskoppal, Deepthi; Deng, Fang-Ming; Snuderl, Matija
ISI:000770360201236
ISSN: 0023-6837
CID: 5243212

Tubulopapillary Carcinoma of the Breast: A Distinct Morphologic Entity with Molecular and Immunohistochemical Analysis [Meeting Abstract]

Salama, Abeer; Schwartz, Christopher; Zhu, Kelsey; Vasudevaraja, Varshini; Serrano, Jonathan; Jour, George; Park, Kyung; Snuderl, Matija; Cotzia, Paolo; Darvishian, Farbod
ISI:000770361800173
ISSN: 0893-3952
CID: 5243282

Comparison of Fresh Cell Pellets and Cell Blocks for Genomic Profiling of Advanced Cancers in Pleural Effusion Specimens: Promising Preliminary Results from a Validation Study [Meeting Abstract]

Chen, Fei; Kim, Christine; Shen, Guomiao; Feng, Xiaojun; Jour, George; Cotzia, Paolo; Brandler, Tamar; Sun, Wei; Snuderl, Matija; Simsir, Aylin; Park, Kyung
ISI:000770361800231
ISSN: 0893-3952
CID: 5243292

Kidney Tumor Classifier Using Whole Genome Methylation Array [Meeting Abstract]

Park, Kyung; Serrano, Jonathan; Chen, Fei; Tran, Ivy; Vasudevaraja, Varshini; Hoskoppal, Deepthi; Deng, Fang-Ming; Snuderl, Matija
ISI:000770361801236
ISSN: 0893-3952
CID: 5243342

Comparison of solid tissue sequencing and liquid biopsy accuracy in identification of clinically relevant gene mutations and rearrangements in lung adenocarcinomas

Lin, Lawrence Hsu; Allison, Douglas H R; Feng, Yang; Jour, George; Park, Kyung; Zhou, Fang; Moreira, Andre L; Shen, Guomiao; Feng, Xiaojun; Sabari, Joshua; Velcheti, Vamsidhar; Snuderl, Matija; Cotzia, Paolo
Screening for therapeutic targets is standard of care in the management of advanced non-small cell lung cancer. However, most molecular assays utilize tumor tissue, which may not always be available. "Liquid biopsies" are plasma-based next generation sequencing (NGS) assays that use circulating tumor DNA to identify relevant targets. To compare the sensitivity, specificity, and accuracy of a plasma-based NGS assay to solid-tumor-based NGS we retrospectively analyzed sequencing results of 100 sequential patients with lung adenocarcinoma at our institution who had received concurrent testing with both a solid-tissue-based NGS assay and a commercially available plasma-based NGS assay. Patients represented both new diagnoses (79%) and disease progression on treatment (21%); the majority (83%) had stage IV disease. Tissue-NGS identified 74 clinically relevant mutations, including 52 therapeutic targets, a sensitivity of 94.8%, while plasma-NGS identified 41 clinically relevant mutations, a sensitivity of 52.6% (p < 0.001). Tissue-NGS showed significantly higher sensitivity and accuracy across multiple patient subgroups, both in newly diagnosed and treated patients, as well as in metastatic and nonmetastatic disease. Discrepant cases involved hotspot mutations and actionable fusions including those in EGFR, ALK, and NTRK1. In summary, tissue-NGS detects significantly more clinically relevant alterations and therapeutic targets compared to plasma-NGS, suggesting that tissue-NGS should be the preferred method for molecular testing of lung adenocarcinoma when tissue is available. Plasma-NGS can still play an important role when tissue testing is not possible. However, given its low sensitivity, a negative result should be confirmed with a tissue-based assay.
PMID: 34362997
ISSN: 1530-0285
CID: 4979862