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36


Can Gleason Grade be Reliably Assigned Based on the Perineural Focus of Adenocarcinoma? [Meeting Abstract]

Chen, Fei; Isaila, Bogdan; Parimi (Parini), Vamsi; Ren, Qinghu; Park, Kyung; Huang, Hongying; Deng, Fangming; Melamed, Jonathan
ISI:000478081101277
ISSN: 0023-6837
CID: 4048352

Integrated Expression (Chromogenic in situ Hybridization) of Long Noncoding RNAs (LncRNAs) Segregate Low Grade from Clinically Significant Prostate Cancer [Meeting Abstract]

Parimi (Parini), Vamsi; Xia, Yuhe; Mezzano, Valeria; Vasudevaraja, Varshini; Selvaraj, Shanmugapriya; Loomis, Cynthia; Moreira, Andre; Lee, Peng; Levy, David; Park, Kyung; Huang, Hongying; Ren, Qinghu; Deng, Fangming; Melamed, Jonathan
ISI:000478081101389
ISSN: 0023-6837
CID: 4048382

Expanding Therapeutic Options for Patients with Lung Adenocarcinomas Using Oncomine Comprehensive Panel [Meeting Abstract]

Park, Kyung; Tran, Hung; Feng, Xiaojun; Rubin, Marka; Fernandes, Helen
ISI:000393724402333
ISSN: 0023-6837
CID: 3133682

Expanding Therapeutic Options for Patients with Lung Adenocarcinomas Using Oncomine Comprehensive Panel [Meeting Abstract]

Park, Kyung; Tian, Hung; Feng, Xiaojun; Rubin, Mark A.; Fernandes, Helen
ISI:000394467302425
ISSN: 0893-3952
CID: 3133702

KRAS Mutation Is Highly Prevalent and Predicts Recurrence in Patients with Primary Invasive Mucinous Adenocarcinoma of the Lung [Meeting Abstract]

Kemel, Mohamed K.; Narula, Navneet; Park, Kyung; Stiles, Brendon M.; Port, Jeffrey L.; Fernandes, Helen; Altorki, Nasser K.
ISI:000394467302509
ISSN: 0893-3952
CID: 3150752

KRAS Mutation Is Highly Prevalent and Predicts Recurrence in Patients with Primary Invasive Mutinous Adenocarcinoma of the Lung [Meeting Abstract]

Kamel, Mohamed K.; Narula, Navneet; Park, Kyung; Stiles, Brendon M.; Port, Jeffrey L.; Fernandes, Helen; Altorki, Nasser K.
ISI:000393724402418
ISSN: 0023-6837
CID: 3151812

Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models

Pisapia, David J; Salvatore, Steven; Pauli, Chantal; Hissong, Erika; Eng, Ken; Prandi, Davide; Sailer, Verena-Wilbeth; Robinson, Brian D; Park, Kyung; Cyrta, Joanna; Tagawa, Scott T; Kossai, Myriam; Fontugne, Jacqueline; Kim, Robert; Sigaras, Alexandros; Rao, Rema; Pancirer, Danielle; Faltas, Bishoy; Bareja, Rohan; Molina, Ana M; Nanus, David M; Rajappa, Prajwal; Souweidane, Mark M; Greenfield, Jeffrey; Emde, Anne-Katrin; Robine, Nicolas; Elemento, Olivier; Sboner, Andrea; Demichelis, Francesca; Beltran, Himisha; Rubin, Mark A; Mosquera, Juan Miguel
Purpose/UNASSIGNED:Patients with cancer who graciously consent for autopsy represent an invaluable resource for the study of cancer biology. To advance the study of tumor evolution, metastases, and resistance to treatment, we developed a next-generation rapid autopsy program integrated within a broader precision medicine clinical trial that interrogates pre- and postmortem tissue samples for patients of all ages and cancer types. Materials and Methods/UNASSIGNED:One hundred twenty-three (22%) of 554 patients who consented to the clinical trial also consented for rapid autopsy. This report comprises the first 15 autopsies, including patients with metastatic carcinoma (n = 10), melanoma (n = 1), and glioma (n = 4). Whole-exome sequencing (WES) was performed on frozen autopsy tumor samples from multiple anatomic sites and on non-neoplastic tissue. RNA sequencing (RNA-Seq) was performed on a subset of frozen samples. Tissue was also used for the development of preclinical models, including tumor organoids and patient-derived xenografts. Results/UNASSIGNED:in metastatic melanoma to the lung. RNA-Seq data identified novel gene fusion candidates. Conclusion/UNASSIGNED:A next-generation sequencing-based autopsy program in conjunction with a pre-mortem precision medicine pipeline for diverse tumors affords a valuable window into clonal evolution, metastasis, and alterations underlying treatment. Moreover, such an autopsy program yields robust preclinical models of disease.
PMCID:5761727
PMID: 29333526
ISSN: 2473-4284
CID: 3061122

Molecular Characterization of Invasive Mucinous Adenocarcinomas of the Lung [Meeting Abstract]

Park, Kyung; Subramaniyam, Shivakwnar; Jessurun, Jose; Fernandes, Helen; Narula, Navneet
ISI:000370302503374
ISSN: 0893-3952
CID: 3150732

Molecular Characterization of Invasive Mucinous Adenocarcinomas of the Lung [Meeting Abstract]

Park, Kyung; Subramaniyam, Shivakumar; Jessurun, Jose; Fernandes, Helen; Narula, Navneet
ISI:000369270703053
ISSN: 0023-6837
CID: 3151772

TMPRSS2-ERG GENE FUSION IS AN UNCOMMON SOMATIC ALTERATION IN HYPOGONADAL MEN WITH PROSTATE CANCER [Meeting Abstract]

Najari, Bobby; Lee, Daniel; Shoag, Jonathan; Park, Kyung; He, Bing; Mosquera, Juan Miguel; Rubin, Mark; Schlegel, Peter; Barbieri, Christopher
ISI:000375539500495
ISSN: 1527-3792
CID: 2189982