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Perceptions of fecal microbiota transplantation for Clostridium difficile infection: factors that predict acceptance

Park, Leslie; Mone, Anjali; Price, Jennifer C; Tzimas, Demetrios; Hirsh, Jacqueline; Poles, Michael A; Malter, Lisa; Chen, Lea Ann
BACKGROUND: Despite the effectiveness of fecal microbiota transplantation (FMT) for treating recurrent Clostridium difficile (C. difficile) infection, some patients are reluctant to accept this therapy. Our study examined attitudes towards FMT and factors that contribute to patients' acceptance of this treatment. METHODS: We distributed patient surveys at a Veterans Affairs hospital, a public hospital, and an academic faculty practice. Multivariable logistic regression was performed, adjusting for factors associated with FMT acceptance on univariate analysis and prior experience with C. difficile infection. RESULTS: Of 267 patients, only 12% knew of FMT prior to the survey, but 77% would undergo the procedure if medically indicated. On multivariable analysis, those with children and with college degrees or higher were more likely to agree to FMT (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.02-4.35; OR 2.27, 95% CI 1.11-4.60 respectively). Sixty-five respondents (71%) chose colonoscopy as the preferred vehicle for FMT, while nasogastric tube was least preferred. Disease transmission was the most common concern (30%, n=242), and FMT success rate was the least selected concern (9.1%). CONCLUSIONS: Most patients in a diverse sample of gastroenterology clinics had no prior knowledge of FMT, but were receptive to the procedure. Having children and higher education levels were predictors for FMT acceptance. Our findings suggest that barriers to FMT utilization may be overcome with counseling about safety concerns. More data on the risk of transmitting diseases or clinical characteristics, such as obesity, through FMT are needed and will be important for the acceptance of this procedure.
PMID: 28042242
ISSN: 1108-7471
CID: 2386482

Clinicopathologic Features of Young Onset Colorectal Cancer Patients: Results From a Large Cohort at a Single Cancer Center [Meeting Abstract]

Park, Leslie; O\Connell, Kelli; Herzog, Keri; Cercek, Andrea; Stadler, Zsofia; Shia, Jinru; Shike, Moshe; Markowitz, Arnold; Guillem, Jose G.; Garcia-Aguilar, Julio; Schattner, Mark; Kantor, Elizabeth; Du, Mengmeng; Mendelsohn, Robin B.
ISSN: 0002-9270
CID: 4552162

When a Sore Throat is Not Your Average Sore Throat: A Case of Crohn's Epiglottitis [Meeting Abstract]

Gold, Stephanie; Cohen-Mekelburg, Shirley; Shah, Shawn; Park, Leslie; Wan, David
ISSN: 0002-9270
CID: 4552172

Perceptions of Fecal Microbiota Transplantation: Factors That Predict Acceptance: A Preliminary Analysis [Meeting Abstract]

Park, Leslie; Tzimas, Demetrios; Price, Jennifer; Mone, Anjali; Hirsh, Jaqueline; Poles, Michael; Malter, Lisa; Chen, Lea Ann
ISSN: 1572-0241
CID: 1443752