Predictors of severe and critical disease in pregnant women with SARS-CoV-2
Limaye, Meghana A; Roman, Ashley S; Trostle, Megan E; Venkatesh, Pooja; Lantigua Martinez, Meralis; Brubaker, Sara G; Chervenak, Judith; Wei, Lili S; Sahani, Parita; Grossman, Tracy B; Meyer, Jessica A; Penfield, Christina A
BACKGROUND/OBJECTIVE/UNASSIGNED:SARS-CoV-2 continues to spread widely in the US and worldwide. Pregnant women are more likely to develop severe or critical illness than their non-pregnant counterparts. Known risk factors for severe and critical disease outside of pregnancy, such as asthma, diabetes, and obesity have not been well-studied in pregnancy. We aimed to determine which clinical and pregnancy-related factors were associated with severe and critical COVID illness in pregnancy. STUDY DESIGN/UNASSIGNED:â€‰<â€‰.05. Multivariable logistic regression was performed including variables that were significantly different between groups. RESULTS/UNASSIGNED:< .01). After adjustment, history of smoking remained significantly predictive of severe/critical disease [aOR 3.84 (95% CI, 1.25-11.82)]. CONCLUSION/UNASSIGNED:Pregnant women with a history of smoking, asthma, or other respiratory condition, and COVID-19 diagnosis in the second trimester of pregnancy were more likely to develop severe/critical disease. These findings may be useful in counseling women on their individual risk of developing the severe or critical disease in pregnancy and may help determine which women are good candidates for vaccination during pregnancy.