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De novo versus nevus-associated melanomas: Differences in associations with prognostic indicators and survival. [Meeting Abstract]

Cymerman, Rachel M; Wang, Kun; Murzaku, Era C; Penn, Lauren A; Osman, Iman; Shao, Yongzhao; Polsky, David
ISI:000358036901935
ISSN: 1527-7755
CID: 1729522

Treatment of olecranon fractures with 2.4- and 2.7-mm plating techniques

Wellman, David S; Lazaro, Lionel E; Cymerman, Rachel M; Axelrad, Thomas W; Leu, David; Helfet, David L; Lorich, Dean G
OBJECTIVES/OBJECTIVE:To evaluate the outcomes of olecranon fractures treated with 2.4- and 2.7-mm plate constructs. DESIGN/METHODS:Retrospective Case Series. SETTING/METHODS:One-level 1 trauma center and 1 tertiary care hospital. PATIENTS/METHODS:Thirty-five consecutive patients meeting inclusion criteria. INTERVENTION/METHODS:A 2.7- or 2.4-mm reconstruction plate was placed on the dorsal ulnar cortex and contoured to allow passage of either a 2.7- or 3.5-mm intramedullary screw. In 9 patients, additional plates were required to control comminution. Available computed tomographic (CT) scans were evaluated for the presence of comminution. MAIN OUTCOME MEASUREMENTS/METHODS:Average Disabilities of the Arm, Shoulder, and Hand (DASH) and Mayo Elbow Performance Score (MEPS). RESULTS:All fractures were united. Average extension deficit was 4.2 degrees, and average flexion angle was 137.4 degrees. Outcome scores were completed by 94% (33/35) of study patients. Average DASH score was 6.6, and average MEPS score was 94.5. Implants were removed in 18 patients. In the cohort of patients with CT scans, 6 of the 7 fractures thought to be simple on plain film analysis were found to have occult comminution on CT scan. CONCLUSIONS:Comminution should be considered in all olecranon fractures, even when plain films display simple patterns; although this did not affect treatment in this series of plated patients, it may be important if selecting tension band wiring. Fixation with 2.4- and 2.7-mm plates addresses comminution in olecranon fractures, avoiding the pitfalls of tension band wiring. In patients with completed outcome scores, 97% (32/33) reported their outcomes as good or excellent according to the MEPS. LEVEL OF EVIDENCE/METHODS:Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
PMID: 24824096
ISSN: 1531-2291
CID: 4728082

A novel computational re-analysis of published GWAS data suggests new risk loci for melanoma susceptibility [Meeting Abstract]

Cymerman, Rachel M; Bigio, Benedetta; Seybold, Martin P; Polsky, David; Wittkowski, Knut M
ISI:000371597104255
ISSN: 1538-7445
CID: 2064482

Analysis of melanoma GWAS data suggests specific risk loci influencing age of onset of melanoma [Meeting Abstract]

Cymerman, Rachel M; Bigio, Benedetta; Seybold, Martin P; Polsky, David; Wittkowski, Knut M
ISI:000371597104256
ISSN: 1538-7445
CID: 2064492

Intramedullary allograft fibula as a reduction and fixation tool for treatment of complex proximal humerus fractures with diaphyseal extension

Berkes, Marschall B; Little, Milton T M; Lazaro, Lionel E; Cymerman, Rachel M; Pardee, Nadine C; Helfet, David L; Dines, Joshua S; Lorich, Dean G
SUMMARY/CONCLUSIONS:In this study, we present a novel technique for reduction and fixation of complex, unstable proximal humerus fractures with diaphyseal extension with the assistance of fibula allograft. We treated 14 patients using this technique since 2009 and found that it improves the reduction and enhances fixation while making the surgical procedure technically more manageable, and allows for early postoperative motion. In the first part of this study, we describe in detail the indications and surgical technique applied to these fractures. In the second part, we review the clinical and radiographic outcomes of these patients. Using this new technique, we have achieved an excellent union rate with minimal incidence of complications when treating these challenging fractures.
PMID: 24561540
ISSN: 1531-2291
CID: 4728072

Association Between Genotype and Age of Presentation of Large Soft Drusen in Early Age-Related Macular Degeneration [Meeting Abstract]

Cymerman, Rachel M.; Pumariega, Nicole Marie; Sperber, Adam; Freund, K. Bailey; Smith, Theodore
ISI:000433203500228
ISSN: 0146-0404
CID: 4728122

Epidemiology, clinical characteristics and complications in ocular foreign body injuries. [Meeting Abstract]

Chae, Bora; Cohen, Elisabeth J.; Cymerman, Rachel M.; Park, Lisa
ISI:000433205501286
ISSN: 0146-0404
CID: 4728132

Association Between Genotype and Choroidal Thickness in Reticular Macular Disease (RMD) [Meeting Abstract]

Pumariega, Nicole Marie; Cymerman, Rachel M.; Sperber, Adam; Freund, K. Bailey; Smith, Theodore
ISI:000433205503020
ISSN: 0146-0404
CID: 4728142

Comparison of supination external rotation type IV ankle fractures in geriatric versus nongeriatric populations

Little, Milton T M; Berkes, Marschall B; Lazaro, Lionel E; Sculco, Peter K; Cymerman, Rachel M; Pardee, Nadine; Helfet, David L; Lorich, Dean G
BACKGROUND:Geriatric patients' (defined as those older than 65 years old) inherent comorbidities, functional limitations, and bone quality present obstacles to successful clinical outcomes for operatively treated supination external rotation (SER) ankle fractures. We retrospectively reviewed a prospectively collected series of SER injuries between 2004 and 2010. This is a comparison of the radiographic and clinical outcomes of our geriatric (27 patients) and nongeriatric (81 patients) populations. We hypothesized that geriatric patients would have worse outcomes when compared to nongeriatric patients. METHODS:All SER ankle fractures (176) treated by a single surgeon were enrolled in a prospective database. All patients fulfilled inclusion criteria (108) consisting of 1 year of having clinical follow-up, postoperative radiographs, and Foot & Ankle Outcome Scores (FAOS). The primary outcome evaluated was functional outcome as exhibited by the FAOS. The secondary outcomes included adequacy of reduction, loss of reduction, postoperative complications (wound complications, infection, pain-driven hardware removal), and range of motion. RESULTS:Despite significantly higher rates of diabetes (P < .001) and peripheral vascular disease (P < .001), there were statistically significantly better FAOS outcomes in the symptoms subcategory among the geriatric population. There was no significant difference in the articular reduction, syndesmotic reduction, wound complications, postoperative infections, or range of motion between these groups. CONCLUSION/CONCLUSIONS:Geriatric patients exhibited equivalent complication rates, radiographic outcomes, and functional outcomes compared to nongeriatric patients in this series. Anatomic fixation and soft tissue management counter the inherent risks of operative intervention in geriatric populations that report higher rates of comorbidities. This study supports aggressive fracture- and ligament-specific operative intervention in geriatric patients presenting with unstable SER injuries.
PMID: 23447508
ISSN: 1071-1007
CID: 4728062

The Dynamics of Hyperreflectant Central Target Lesions In Reticular Macular Disease (RMD) In Age-related Macular Degeneration (AMD) [Meeting Abstract]

Pumariega, Nicole; Cymerman, Rachel; Butler, Brendan; Massamba, Nathalie; Souied, Eric; Smith, Roland
ISI:000436232900060
ISSN: 0146-0404
CID: 4728152