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P73. Change of cervical sagittal alignment after surgery for adolescent idiopathic scoliosis (AIS): comparison of vertebral body tethering (VBT) versus posterior spinal fusion [Meeting Abstract]

Ani, F; Burapachaisri, A; Kim, N S; Bono, J; Ashayeri, K; O'Connell, B K; Maglaras, C; Raman, T; Protopsaltis, T S; Olaverri, J C R
BACKGROUND CONTEXT: VBT takes advantage of the Hueter-Volkmann principle, and modulates growth across intervertebral disc spaces with a tensioned tether secured at the lateral aspects of vertebral bodies. Cervical deformity in AIS patients is associated with lower health related quality of life. PSF constructs have been shown to improve cervical deformity, however, to date, these relationships have not been described in patients treated with VBT. PURPOSE: Determine if cervical sagittal alignment parameters following VBT for correction of AIS are similar to what is observed following PSF. STUDY DESIGN/SETTING: Multi-center retrospective cohort study. PATIENT SAMPLE: Patients with AIS that undergo correction surgeries with LIV in the lumbar spine from 2013 to 2021 with pre- and 2-year postop standing full body plain films available. OUTCOME MEASURES: Outcome measures: Age, height, weight, BMI, Risser score, LIV and levels instrumented. Radiographic analysis included pre- and postop C2 to C7 sagittal vertical axis (cSVA), cervical lordosis angle (CL), T1 slope and thoracic kyphosis (TK).
METHOD(S): Measures were compared using independent samples t-tests, significance set at p<0.05.
RESULT(S): A total of 99 patients: 49 VBT and 50 fusions. The VBT cohort Lenke class breakdown is 23% 1A, 13% 1C, 31% 3C; 18% 5C, and 15% 6C, while the PSF cohort consisted of 42% 1A, 6% 1B, 2% 2C, 2% 3B, 12% 3C, 2% 5B, 24% 5C, and 10% 6C. There were no significant differences with regard to patient age or number of levels instrumented. Patients included in the VBT cohort had a lower level of bone maturity as defined by Risser class (1.6+/-0.9 vs 2.6+/-1.8, p=0.001). The VBT cohort had higher baseline cSVA (3.4mm+/-1.6 vs -1.0mm+/-3.1, 0.001) and less CL (-0.6degree+/-18.2 vs 11.6degree+/-12.8, p=0.001) than the fusion cohort. No differences in baseline T1 slope or Thoracic Kyphosis was observed. VBT patients also had higher 2-year cSVA (3.4mm+/-1.4 vs -3.7mm+/-2.1, p=0.001) and less CL (-4.0+/-18.5 vs 7.0+/-12.2, p=0.001) compared to fusion patients. The PSF group had a significantly greater correction in cSVA than the VBT group (2.8mm+/-4.0 vs 0mm+/-1.6, p=0.001). Both groups displayed improvement in radiographic parameters of cervical and thoracic alignment including CL (VBT 3.3degreevs 4.3degree, p=0.74), T1 slope (VBT -4.3degreevs -4.9degree, p=0.81) and TK (VBT -6.1degreevs -3.9degree, p=0.47). After PSM for Lenke classification, 66 patients remained: 33 VBT, 33 PSF. The PSF group continued to demonstrate greater improvement in cSVA than the VBT group (3.2mm+/-3.0 vs -0.3+/-1.8, p=0.001.
CONCLUSION(S): VBT and PSF both improve radiographic parameters of cervical alignment in AIS patients; however, PSF showed greater correction of cSVA at 2-year followup. FDA DEVICE/DRUG STATUS: This abstract does not discuss or include any applicable devices or drugs.
ISSN: 1878-1632
CID: 5510702

131. Sagittal profile modifications in vertebral body tethering (VBT) versus posterior spinal fusion (PSF) in adolescent idiopathic scoliosis (AIS) [Meeting Abstract]

Ani, F; Kim, N S; Bono, J; Burapachaisri, A; Ashayeri, K; O'Connell, B K; Maglaras, C; Raman, T; Protopsaltis, T S; Olaverri, J C R
BACKGROUND CONTEXT: Sagittal alignment is integral to a patient's quality of life. Posterior spinal fusion (PSF) is currently the standard for correcting adolescent idiopathic scoliosis (AIS). Vertebral body tethering (VBT) is a fusionless growth modulating surgical technique used to treat AIS. It relies on the Hueter-Volkmann Law. Indications for this procedure include patients who have coronal curves up to 50degree, growth remaining, and no excessive thoracic kyphosis. VBT has been shown to have good coronal plane deformity correction. There have been fewer examinations of the sagittal effects of VBT. PURPOSE: To determine if VBT is a non-inferior treatment for correction of AIS with regard to sagittal alignment compared to PSF. STUDY DESIGN/SETTING: Multicenter retrospective cohort study. PATIENT SAMPLE: Patients with AIS who underwent correction surgeries with LIV in the lumbar spine from 2013 to 2021 with pre- and minimum two-year postoperative standing full spine plain films. OUTCOME MEASURES: Sagittal vertical axis (SVA), cervical SVA (cSVA), pelvic tilt (PT), thoracic kyphosis (TK), cervical lordosis (CL), L4-S1 lordosis (L4L), T1 pelvic angle (TPA) and pelvic incidence lumbar lordosis mismatch (PI-LL).
METHOD(S): Radiographic analyses was completed with independent samples t-test with significance set to p <0.05.
RESULT(S): A total of 99 patients were included, 49 VBT and 50 PSF. There were no differences in age or levels instrumented between groups. The VBT cohort Lenke class breakdown is 23% 1A, 13% 1C, 31% 3C. 18% 5C, and 15% 6C, while the PSF cohort consisted of 42% 1A, 6% 1B, 2% 2C, 2% 3B, 12% 3C, 2% 5B, 24% 5C, and 10% 6C. At Baseline, the VBT cohort had lower SVA (-0.7mm+/-3.7 vs 2.2mm+/-5.0, p=0.001), CL (-0.9degree+/-18.2 vs 11.6degree+/-12.8, p=0.001), L4-S1 Lordosis (20.7degree+/-16.0 vs 41.6degree+/-10.2, p=0.001), and higher cSVA (3.3mm+/-1.6 vs -0.95mm+/-3.1, p=0.001) than those who were fused. Postoperatively, VBT patients have an overall higher L4-S1 Lordosis (36.0degree+/-10.1vs 18.3degree+/-12.5, p=0.001), cSVA (3.4mm+/-1.4 vs -3.7mm+/-2.1, p=0.001), and lower CL (-4.3degree+/-18.4 vs 7.0degree+/-12.2, p=0.001). The PSF cohort had a larger change in cSVA (2.8mm+/-4.0 vs 0mm+/-1.6, p=0.001) from baseline to 2-year follow-up compared to VBT. No differences in the change of L4-S1 Lordosis (VBT 1.5degree+/-12.3 vs 4.1degree+/-10.9, p=0.3), TPA (VBT -1.6degree+/-6.8 vs -1.4degree+/-8.5, p=0.89), PT (VBT -0.5degree+/-7.8 vs -1.9degree+/-8.5, p=0.42), or PI-LL (0.2degree+/-12.0 vs -0.5degree+/-14.0, p=0.81) were observed.
CONCLUSION(S): VBT and PSF for AIS result in statistically similar changes in sagittal alignment parameters. The fact that we showed similar results comparing sagittal alignment in fusion and VBT groups indicates that VBT is non-inferior from a sagittal perspective. It is important to maintain sagittal alignment when correcting AIS. Future work can examine the long-term effect of VBT on sagittal alignment. FDA DEVICE/DRUG STATUS: This abstract does not discuss or include any applicable devices or drugs.
ISSN: 1878-1632
CID: 5511162

Partial facetectomy for lumbar foraminal stenosis

Kang, Kevin; Rodriguez-Olaverri, Juan Carlos; Schwab, Frank; Hashem, Jenifer; Razi, Afshin; Farcy, Jean Pierre
Background. Several different techniques exist to address the pain and disability caused by isolated nerve root impingement. Failure to adequately decompress the lumbar foramen may lead to failed back surgery syndrome. However, aggressive treatment often causes spinal instability or may require fusion for satisfactory results. We describe a novel technique for decompression of the lumbar nerve root and demonstrate its effectiveness in relief of radicular symptoms. Methods. Partial facetectomy was performed by removal of the medial portion of the superior facet in patients with lumbar foraminal stenosis. 47 patients underwent the procedure from 2001 to 2010. Those who demonstrated neurogenic claudication without spinal instability or central canal stenosis and failed conservative management were eligible for the procedure. Functional level was recorded for each patient. These patients were followed for an average of 3.9 years to evaluate outcomes. Results. 27 of 47 patients (57%) reported no back pain and no functional limitations. Eight of 47 patients (17%) reported moderate pain, but had no limitations. Six of 47 patients (13%) continued to experience degenerative symptoms. Five of 47 patients (11%) required additional surgery. Conclusions. Partial facetectomy is an effective means to decompress the lumbar nerve root foramen without causing spinal instability.
PMID: 25110591
ISSN: 2090-3464
CID: 1131912

Infections in spinal instrumentation

Gerometta, Antoine; Olaverri, Juan Carlos Rodriguez; Bitan, Fabian
Surgical-site infection (SSI ) in the spine is a serious postoperative complication. Factors such as posterior surgical approach, arthrodesis, use of spinal instrumentation, age, obesity, diabetes, tobacco use, operating-room environment and estimated blood loss are well established in the literature to affect the risk of infection. Infection after spine surgery with instrumentation is becoming a common pathology. The reported infection rates range from 0.7% to 11.9%, depending on the diagnosis and complexity of the procedure. Besides operative factors, patient characteristics could also account for increased infection rates. These infections after instrumented spinal fusion are particularly difficult to manage due to the implanted, and possibly infected, instrumentation. Because the medical, economic and social costs of SSI after spinal instrumentation are enormous, any significant reduction in risks will pay dividends. The goal of this literature review was to analyse risk factors, causative organisms, diagnostic elements (both clinical and biological), different treatment options and their efficiency and consequences and the means of SSI prevention.
PMID: 22218913
ISSN: 0341-2695
CID: 160257

Infection and revision strategies in total disc arthroplasty

Gerometta, Antoine; Rodriguez Olaverri, Juan Carlos; Bittan, Fabian
PURPOSE: Our aim was to revise the different strategies for treating an infected disc arthroplasty. METHODS: Despite recognition that disc replacement may reduce the incidence of adjacent-segment disease, the risk of potential complications associated with primary and revision total disc arthroplasty has diminished surgeon enthusiasm for the procedure. We performed a literature review of the different revision strategies for an infected disc arthroplasty. RESULTS: The need for revision of lumbar total disc arthroplasty has been reported in a number of prospective, randomised trials (level I or II evidence). Suboptimal patient selection and/or surgical technique accounted for the majority of failed disc arthroplasties. Revision procedures include posterior stabilisation or anterior extraction and conversion to arthrodesis. The risk of injury to the great vessels and retroperitoneal structures is greater during revision than primary procedures. The use of a distant lateral, or transpsoas, approach to the anterior column may reduce these adverse events. Also, the use of adhesion barriers has been shown to reduce adhesions in abdominal and pelvic surgery and may be of benefit in revision disc arthroplasty. CONCLUSION: This review article provides an update on the various treatments for infected lumbar disc prosthesis and the different surgical approaches used in these difficult cases. It also describes potential options to avoid complications associated with the revision surgical approach.
PMID: 22198361
ISSN: 0341-2695
CID: 932302

Postoperative spondilodiscitis

Gerometta, Antoine; Bittan, Fabian; Rodriguez Olaverri, Juan Carlos
INTRODUCTION: Postoperative spondylodiscitis is a primary infection of the nucleus pulposus with secondary involvement of the cartilaginous endplate and vertebral bone. Although uncommon, postoperative spondylodiscitis causes major morbidity and may be associated with serious long-term sequelae. Several risk factors had been identified, including immunosuppression, obesity, alcohol, smoking, diabetes and malnutrition. MATERIALS AND METHODS: A review of the literature was done to analyse the diagnosis, treatment and prevention of postoperative spondylodiscitis. RESULTS: We found that the principles of conservative treatment are to establish an accurate microbiological diagnosis, treat with appropriate antibiotics, immobilise the spine, and closely monitor for spinal instability and neurological deterioration. The purpose of surgical treatment is to obtain multiple cultures of bone and soft tissue, perform a thorough debridement of infected tissue, decompress neural structures, and reconstruct the unstable spinal column with bone graft with or without concomitant instrumentation. CONCLUSIONS: Appropriate management requires aggressive medical treatment and, at times, surgical intervention. If recognised early and treated appropriately, a full recovery can often be expected. Therefore, clinicians should be aware of the clinical presentation of such infections to improve patient outcome. A review of the literature was done to advance our understanding of the diagnosis, treatment, prevention and outcome of these infections.
PMID: 22307558
ISSN: 0341-2695
CID: 932312

Comparing the clinical and radiological outcomes of pedicular transvertebral screw fixation of the lumbosacral spine in spondylolisthesis versus unilateral transforaminal lumbar interbody fusion (TLIF) with posterior fixation using anterior cages [Case Report]

Rodriguez-Olaverri, Juan C; Zimick, Nicholas C; Merola, Andrew; Vicente, Javier; Rodriguez, Javier; Tabuenca, Antonio; Loste, Antonio; Sunen, Enrique; Burgos, Jesus; Hevia, Eduardo; Piza-Vallespir, Gabriel
STUDY DESIGN: This study retrospectively compares the clinical and radiologic outcomes of unilateral transforaminal lumbar interbody fusion (TLIF) with those of transvertebral screw fixation of the lumbosacral spine in high-grade spondylolisthesis. OBJECTIVE: To examine the outcome and perioperative complications of unilateral TLIF and compare those results with Transvertebral Screw Fixation in the treatment of high-grade spondylolisthesis. SUMMARY OF BACKGROUND DATA: High-grade spondylolisthesis has been associated with a high complication and failure rate regardless of the method of treatment. We compare 2 techniques to improve success rates. METHODS: Forty patients were divided into 2 groups: group A, unilateral TLIF, and group B, transacral screws. The mean age was 33 years (range, 19-48 years), and the mean follow-up was 35 months (range, 24-48 months). The mean grade of spondylolisthesis measured by Meyerding grading was 3.6 (range, 3-5). A Scoliosis Research Society outcome score was obtained on all patients. Fusion was determined by both radiograph and computed tomography scan. RESULTS: Group A: 100% fusion. The slip angle improved from 38.6 degrees (range, 24-78 degrees ) before surgery to 23.8 degrees (range, 12-38 degrees ) after surgery. Group B: 95% of patients evidenced solid fusion by the 6-month follow-up. The slip angle, improved from 38.2 degrees (range, 22-78 degrees ) before surgery to 23 degrees (range, 9-36 degrees ) after surgery. There was no significant improvement in the percentage slip or the sacral inclination in any of the groups. Complications: A: 7 unintended durotomies and 3 wound infections. B: 1 unintended durotomy, 1 pseudarthrosis, 2 wound infections, and 1 implant failure. There were no neurologic complications in any of the groups. The Scoliosis Research Society outcome instrument demonstrated good postoperative pain control, function, self-image, and satisfaction in both groups. CONCLUSION: No significant differences in radiologic and clinical outcome were found, in either group. Both procedures appear to be safe and effective surgically and radiographically
PMID: 18708930
ISSN: 1528-1159
CID: 104463

Vertebral coplanar alignment: a standardized technique for three dimensional correction in scoliosis surgery: technical description and preliminary results in Lenke type 1 curves

Vallespir, Gabriel Piza; Flores, Jesus Burgos; Trigueros, Ignacio Sanpera; Sierra, Eduardo Hevia; Fernandez, Pedro Domenech; Olaverri, Juan Carlos Rodriguez; Alonso, Manuel Garcia; Galea, Rafael Ramos; Francisco, Antonio Perez; Rodriguez de Paz, Beatriz; Carbonell, Pedro Gutierrez; Thomas, Javier Vicente; Lopez, Jose Luis Gonzalez; Paulino, Jose Ignacio Maruenda; Pitarque, Carlos Barrios; Garcia, Oscar Riquelme
STUDY DESIGN: Prospective multicentric study. OBJECTIVE: To present the preliminary results of an innovative method for standardized correction of scoliosis, vertebral coplanar alignment (VCA), based on a novel concept: the relocation of vertebral axis in a single plane. SUMMARY OF BACKGROUND DATA: Normal standing spine has no rotation in coronal or transverse planes, therefore X and Z axis of vertebrae are in the same plane: they are coplanar. VCA intends to relocate these axis in one plane, correcting rotation and translation, while X axis are returned to its normal posterior divergence in sagittal plane in thoracic spine. METHODS: Twenty-five consecutive adolescent idiopathic scoliosis patients (Lenke type 1) underwent posterior surgery with segmental pedicle screw fixation. Slotted tubes were attached to convex side screws. Two longitudinal rods were inserted through the end of tubes. Then, they were separated along the slots, driving the tubes into one plane, making the axis of the vertebrae coplanar and thus correcting transverse rotation and coronal translation. To obtain kyphosis, distal ends of the tubes were spread in thoracic spine. Correction was maintained by locking a definitive rod in the concave side, then tubes were retrieved and the convex side rod, inserted and tightened. Correction was assessed on preoperative and postoperative full-spine standing radiograph. Vertebral rotation was measured on computed tomography-scan and magnetic resonance imaging. RESULTS: Preoperative average thoracic curves of 61 degrees were corrected to 16 degrees (73%). Preoperative average thoracolumbar curves of 39 degrees were corrected to 12 degrees (70%). Preoperative average thoracic apical rotation of 24 degrees was corrected to 11 degrees (56%). Preoperative average thoracic kyphosis of 18 degrees remained unchanged after surgery; however, no patients had kyphosis <10 degrees after surgery. Rib hump improved from 30 to 11 mm (65%). There were no perioperative complications. CONCLUSION: VCA provided excellent correction of coronal and transverse planes with normalization of thoracic kyphosis in Lenke type 1 adolescent idiopathic scoliosis surgery
PMID: 18552675
ISSN: 1528-1159
CID: 104466

Using triggered electromyographic threshold in the intercostal muscles to evaluate the accuracy of upper thoracic pedicle screw placement (T3-T6) [Case Report]

Rodriguez-Olaverri, Juan C; Zimick, Nicholas C; Merola, Andrew; De Blas, Gema; Burgos, Jesus; Piza-Vallespir, Gabriel; Hevia, Eduardo; Vicente, Javier; Sanper, Ignacio; Domenech, Pedro; Regidor, Ignacio
STUDY DESIGN: A prospective clinical study of high thoracic pedicle screws monitored with triggered electromyographic (EMG) testing. OBJECTIVE: To evaluate the sensitivity of recording intercostal muscle potentials to assess upper thoracic screw placement. SUMMARY OF BACKGROUND DATA: Triggered EMG testing from rectus muscle recordings, which are innervated from T6 to T12, has identified medially placed thoracic pedicle screws. No clinical study has correlated an identical technique with the intercostal muscle for upper pedicle screws placed in the upper thoracic spine (T3-T6). METHODS: A total of 311 high thoracic screws were placed in 50 consecutive patients. Screws were placed from T3 to T6 and were evaluated using an ascending method of stimulation until a compound muscle action potential was obtained from the intercostal muscles. Screw position was then evaluated using computed tomography and results were compared with evoked EMG threshold values. RESULTS: Fifteen screws (5%) showed penetration on postoperative computed tomography scans. Eleven screws showed medial cortical breakthrough (3.6%), 6 had stimulation thresholds <or=6 mA, and 5 had stimulation thresholds between 6 and 10 mA. Stimulation values for all breached screws decreases 60% to 65% from their mean. Four screws (1.3%) showed lateral cortical breakthrough with stimulation thresholds >20 mA. Of the 296 screws with thresholds between 6 and 20 mA, 285 (91%) were within the vertebra. No postoperative neurologic complications were noted in any of the 50 patients. CONCLUSION: In this series, cortical violation is highly unlikely in patients whose stimulation threshold lies between 6 and 20 mA with values 60% to 65% decreased from the mean (98% negative predictive value). Although verification of screw placement should not depend solely on stimulation thresholds, pedicle screw stimulation provides rapid and useful intraoperative information on screw placement during procedures involving the use of thoracic pedicle screws
PMID: 18379388
ISSN: 1528-1159
CID: 104464

Perforation of the sigmoid colon in a rheumatoid arthritis patient treated with methylprednisolone pulses [Case Report]

Candelas, G; Jover, J A; Fernandez, B; Rodriguez-Olaverri, J C; Calatayud, J
We describe a 61 year-old caucasian male diagnosed with rheumatoid arthritis. He was started on methylprednisolone pulses because of a severe flare of symmetric polyarthritis while he was on weekly intramuscular methotrexate and low-dose oral prednisone. After the second pulse of methylprednisolone the patient suddenly developed severe abdominal pain with free air under the right hemidiaphragm in the chest roentgenogram. The emergency surgery revealed the perforation of a colonic diverticulum. We suggest that methylprednisolone pulses should be carefully used in those patients over 50 years of age and/or people with demonstrated or suspected diverticular disease
PMID: 9572644
ISSN: 0300-9742
CID: 104465