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Death From COVID-19 in a Patient Receiving Clozapine: Factors Involved and Prevention Strategies to Consider

Llesuy, Joan Roig; Sidelnik, S Alex
PMID: 32706942
ISSN: 2155-7780
CID: 4535382

Catatonia Under-Diagnosis in the General Hospital

Llesuy, Joan Roig; Medina, Michel; Jacobson, Kristen C; Cooper, Joseph J
Catatonia is under-diagnosed in psychiatric settings. No studies have explored the under-diagnosis of catatonia in general hospitals. The authors conducted a retrospective chart review using DSM-5 criteria to diagnose catatonia in medical inpatients between 2011 and 2013. Of 133 case subjects meeting DSM-5 criteria for catatonia retrospectively, 79 had never been diagnosed and 54 had a documented diagnosis. Multiple logistic regression revealed that psychiatry consultation significantly decreased the odds of under-diagnosis of catatonia, whereas presence of agitation, grimacing, or echolalia increased the likelihood of under-diagnosis. Under-diagnosed case subjects received significantly lower doses of lorazepam, and increased mortality during admission and increased length of hospital stay both fell short of statistical significance in this group. Catatonia appears to be frequently under-diagnosed in the general hospital, and psychiatry consultation services play a crucial role in its detection and treatment. Strategies to improve recognition and treatment of catatonia should be implemented.
PMID: 29325478
ISSN: 1545-7222
CID: 5000242

Catatonia Education: Needs Assessment and Brief Online Intervention

Cooper, Joseph J; Roig Llesuy, Joan
OBJECTIVES/OBJECTIVE:There are no studies investigating physicians' knowledge of catatonia. The authors aimed to assess and increase physicians' awareness of catatonia. METHODS:A survey with clinical questions about catatonia was administered, followed by a brief online teaching module about catatonia and a post-education survey. RESULTS:Twenty-one psychiatry residents (response rate, 70%) and 36 internal medicine residents (response rate, 34%) participated in the pre-education survey. Psychiatry residents identified 75% of the correct answers about catatonia, compared to 32% correct by internal medicine residents (p < 0.001). Twenty participants (response rate, 35%) completed the online education module and second survey, which resulted in a significant improvement in correct response rates from 60 to 83% in all the participants (p < 0.001). CONCLUSIONS:Residents' baseline knowledge of catatonia is low, particularly among internal medicine residents. A brief online module improved resident physicians' knowledge of catatonia. Educational strategies to improve recognition of catatonia should be implemented.
PMID: 27837452
ISSN: 1545-7230
CID: 5000262

Suspected Delirium Predicts the Thoroughness of Catatonia Evaluation

Llesuy, Joan Roig; Coffey, M Justin; Jacobson, Kristen C; Cooper, Joseph J
Although commonly linked to psychiatric disorders, catatonia is frequently identified secondary to neurological and general medical conditions (GMCs). The present study aimed to characterize the diagnostic workup of cases of catatonia in a general hospital setting. The authors performed a retrospective chart review of 54 cases of catatonia, over 3 years. Clinical suspicion of comorbid delirium was the strongest predictor of a more thorough general medical workup. Attribution of catatonia to a psychiatric etiology was associated with significantly less diagnostic workup. Prospective studies should help clarify the relationship between catatonia and delirium and standardize the diagnostic approach to patients presenting with catatonia.
PMID: 27899050
ISSN: 1545-7222
CID: 5000232

Cavum septum pellucidum in schizophrenia: a case report [Case Report]

Roig Llesuy, J; Olondo Zulueta, M L; Parellada Rodón, E
Different structural alterations of the central nervous system (CNS), such as an increase in ventricular size, decrease in hippocampus and amygdala volume, and other abnormalities that are probably secondary to a loss of neuronal mass and neuropili (axons and dendrite ramifications) linked to a precocious alteration in neurodevelopment are described in patients with schizophrenia in greater proportion than in the general population. The cavum septum pellucidum is among the alterations whose role in the disease is more unknown, since the cavity between the two septum laminae draws attention in very few cases. According to several studies, this alteration is more frequent in patients with schizophrenia than in healthy subjects and currently its association to the disease is being studied. In the following, we present the case of a 37 year old patient with no outstanding background, who was admitted to our psychiatry department due to psychotic symptoms.
PMID: 18004677
ISSN: 1139-9287
CID: 5000252