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A Case of a Primary Intratesticular Leiomyosarcoma with Metastatic Disease

Berg, Courtney; Vedula, Jogarao; Sueur, Amanda Le; Drexler, Steven; Schiff, Jeffrey
PMID: 31470025
ISSN: 1527-9995
CID: 4054042

Intestinal Neuronal Dysplasia Type B: Timely Diagnosis and Management [Meeting Abstract]

Deerwester, Mona; Drexler, Steven
ISSN: 0002-9173
CID: 4284892

Acute anoxic changes in peripheral nerve: anatomic and physiologic correlations

Punsoni, Michael; Drexler, Steven; Palaia, Thomas; Stevenson, Matthew; Stecker, Mark M
INTRODUCTION/BACKGROUND:The response of the peripheral nerve to anoxia is modulated by many factors including glucose and temperature. The purposes of this article are to demonstrate the effects of these factors on the pathological changes induced by anoxia and to compare the electrophysiologic changes and pathological changes in the same nerves. METHODS:Sciatic nerves were harvested from rats and placed in a perfusion apparatus where neurophysiologic responses could be recorded continuously during a 16 h experiment. After the experiment, light microscopy and electron microscopy were performed. RESULTS:Light microscopic images showed mild changes from anoxia at normoglycemia. Hypoglycemic anoxia produced massive axonal swelling while hyperglycemic anoxia produced apparent changes in the myelin. Anoxic changes were not uniform in all axons. Electron microscopy showed only minor disruptions of the cytoskeleton with anoxia during normoglycemia. At the extremes of glucose concentration especially with hyperglycemia, there was a more severe disruption of intermediate filaments and loss of axonal structure with anoxia. Hypothermia protected axons from the effect of anoxia and produced peak axonal swelling in the 17-30°C range. CONCLUSIONS:The combination of hyperglycemia or hypoglycemia and anoxia produces extremely severe axonal disruption. Changes in axonal diameter are complex and are influenced by many factors.
PMID: 26221572
ISSN: 2162-3279
CID: 3461542

Primary CNS T-cell lymphoma of the spinal cord: case report and literature review [Case Report]

Guzzetta, Melissa; Drexler, Steven; Buonocore, Brian; Donovan, Virginia
Primary central nervous system lymphoma (PCNSL) accounts for 1% of all lymphoma diagnoses and as many as 6% of all central nervous system (CNS) tumors. Most cases of PCNSL are of B-cell type; few are of T-cell lineage. PCNSL mainly occurs intracranially; primary spinal-cord lymphoma only occurs rarely. Moreover, intramedullary presentation without intracranial lesions is virtually unknown. Herein, we present a case of primary T-cell CNS lymphoma limited to the intramedullary spinal cord in an 82-year-old white man, along with a review of the literature on this condition and similar conditions.
PMID: 25918197
ISSN: 1943-7730
CID: 2180412

Cell proliferation Rate by MIB-1 Immunohistochemistry in Meningiomas Correlates with World Health Organization Histopathologic Grade and Recurrence [Meeting Abstract]

Groh, Darren; Drexler, Steven
ISSN: 0002-9173
CID: 3461512

A Case Report: Primary Cutaneous Chondrosarcoma Metastatic to the Brain [Meeting Abstract]

Tseng, Yun-An; Youn, Trisha; Eisenkraft, Barbara; Drexler, Steven
ISSN: 0002-9173
CID: 3003372

Pituicytoma: A Rare But Recurring Tumor [Meeting Abstract]

Punsoni, Michael; Tanpitukpongse, Teerath P.; Ortiz, A. Orlando; Holtzman, Robert N.; Drexler, Steven
ISSN: 0002-9173
CID: 3461532

An Unexpected Case of Cerebral Histoplasmoma [Meeting Abstract]

Punsoni, Michael; Tanpitukpongse, Teerath Peter; Ortiz, A. Orlando; Drexler, Steven
ISSN: 0002-9173
CID: 3461522

Radiology-pathology conference. Acinar cell carcinoma of the pancreas [Case Report]

Khalili, Michael; Wax, Bobbi N; Reed, William P; Schuss, Allan; Drexler, Steven; Weston, Shiobhan R; Katz, Douglas S
Acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of pancreatic neoplasms. ACC is defined as a carcinoma exhibiting pancreatic enzyme production by neoplastic cells. Clinical presentation is usually related to either local spread or metastasis. In this Radiology-Pathology Conference, the clinical presentation and imaging findings of a patient with ACC of the pancreas, along with the differential diagnosis, are reviewed.
PMID: 16919557
ISSN: 0899-7071
CID: 2097262

An 18-year-old man with persistent cough and bilateral lower lung infiltration. Epstein-Barr virus-positive lymphoproliferative disorder consistent with lymphomatoid granulomatosis [Case Report]

Hu, Xuejiao; Selbs, Elena; Drexler, Steven
PMID: 16519586
ISSN: 1543-2165
CID: 3461572