Randomized clinical trial of high concentration versus titrated oxygen use in pediatric asthma
OBJECTIVE:in the pediatric population. METHOD:The study design is a prospective, randomized, clinical trial comparing HCOT (maintain SpO2 92-95%) while being treated for asthma exacerbation in theÂ emergency department (ED). INCLUSION CRITERIA:. Secondary outcomes were admission rate and change in asthma score. RESULTS:was higher in the HCOT (38.08â€‰+â€‰5.11 HCOT vs 35.51â€‰+â€‰4.57 TOT, Pâ€‰=â€‰0.01). The asthma score was similar at 0â€‰minute (7.55â€‰+â€‰1.34 HCOT vs 7.30â€‰+â€‰1.18 TOT, Pâ€‰=â€‰0.33); whereas, the 60â€‰minutes asthma score was lower in the TOT (4.71â€‰+â€‰1.38 HCOT vs 3.57â€‰+â€‰1.25 TOT, Pâ€‰=â€‰0.0001). The rate of admission to the hospital was 40.5% in HCOT vs 25.5% in the TOT (Pâ€‰=â€‰0.088). CONCLUSIONS:HCOT in pediatric asthma exacerbation leads to significantly higher carbon dioxide levels, which increases asthma scores and trends towards the increasing rate of admission. Larger studies are needed to explore this association.