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Randomized clinical trial of high concentration versus titrated oxygen use in pediatric asthma

Patel, Bhavi; Khine, Hnin; Shah, Ami; Sung, Deborah; Medar, Shivanand; Singer, Lewis
OBJECTIVE:in the pediatric population. METHOD:The study design is a prospective, randomized, clinical trial comparing HCOT (maintain SpO2 92-95%) while being treated for asthma exacerbation in the emergency department (ED). INCLUSION CRITERIA:. Secondary outcomes were admission rate and change in asthma score. RESULTS:was higher in the HCOT (38.08 + 5.11 HCOT vs 35.51 + 4.57 TOT, P = 0.01). The asthma score was similar at 0 minute (7.55 + 1.34 HCOT vs 7.30 + 1.18 TOT, P = 0.33); whereas, the 60 minutes asthma score was lower in the TOT (4.71 + 1.38 HCOT vs 3.57 + 1.25 TOT, P = 0.0001). The rate of admission to the hospital was 40.5% in HCOT vs 25.5% in the TOT (P = 0.088). CONCLUSIONS:HCOT in pediatric asthma exacerbation leads to significantly higher carbon dioxide levels, which increases asthma scores and trends towards the increasing rate of admission. Larger studies are needed to explore this association.
PMID: 30945478
ISSN: 1099-0496
CID: 5228542