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Intradiscal electrothermal therapy, nucleoplasty and biacuplasty

Chapter by: Calvino, Steven; Bannis, Rohan; Shah, Sachin
in: Spinal disorders and treatments : the NYU-HJD comprehensive textbook by Errico, Thomas J; Cheriyan, Thomas; Varlotta, Gerard P [Eds]
New Delhi : Jaypee Brothers, 2015
pp. 259-263
ISBN: 9351524957
CID: 2709332

Complications of ultrarapid opioid detoxification with subcutaneous naltrexone pellets [Case Report]

Hamilton, Richard J; Olmedo, Ruben E; Shah, Sachin; Hung, Oliver L; Howland, Mary Ann; Perrone, Jeanmarie; Nelson, Lewis S; Lewin, Neal L; Hoffman, Robert S
Rapid and ultrarapid opioid detoxification (ROD and UROD) centers promise quick, painless, same-day detoxification treatment for patients with opioid addiction. The goal of ROD and UROD is to provide a rapid transition from opioid dependency to oral naltrexone therapy. The patient is given general anesthesia and high-dose opioid antagonists. This induces a severe withdrawal but spares the patient the experience. In theory, the process is complete within four to five hours. The patient awakens without opioid dependency and is started on oral naltrexone. Any subsequent, persistent withdrawal symptoms are treated symptomatically. A novel, unapproved approach is to compound a pellet of naltrexone and implant it in the subcutaneous tissue. In theory, this should result in continuous therapeutic levels for this drug, and avoid issues with noncompliance. CASE SERIES: This article reports six cases of complications from the same detoxification center that performed UROD with naltrexone pellet implantation, including pulmonary edema, prolonged withdrawal, drug toxicity, withdrawal from cross-addiction to alcohol and benzodiazepines, variceal rupture, aspiration pneumonia, and death. CONCLUSIONS: The risks of this procedure are great and further studies should assess its safety and the novel use of naltrexone
PMID: 11772672
ISSN: 1069-6563
CID: 69722