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Endoscopic Endonasal Approach for Direct Puncture Embolization of Cavernous Dural Arteriovenous Fistula: 2-Dimensional Operative Video

Sangwon, Karl L; Esparza, Rogelio; Sharashidze, Vera; Dastagirzada, Yosef; Shapiro, Maksim; Riina, Howard A; Lieberman, Seth; Pacione, Donato; Raz, Eytan; Nossek, Erez
PMID: 37831980
ISSN: 2332-4260
CID: 5604252

Transpalpebral/Blepharoplasty Incision and Supraorbital Craniotomy for the Treatment of Ethmoidal Dural Arteriovenous Fistulas: A Case Series

Hagstrom, Rory; Nossek, Erez; Rutledge, Caleb W; Ponchione, Elizabeth; Suryadevara, Carter; Kremer, Caroline; Alcon, Andre; Sharashidze, Vera; Shapiro, Maksim; Raz, Eytan; Nelson, Peter K; Staffenberg, David A; Riina, Howard A
BACKGROUND AND OBJECTIVES/OBJECTIVE:Inherent complex angioarchitecture associated with ethmoidal dural arteriovenous fistulas (dAVFs) can make endovascular treatment methods challenging. Many surgical approaches are accompanied by unfavorable cosmetic results such as facial scarring. Blepharoplasty incision of the eyelid offers a minimal, well-hidden scar compared with other incision sites while offering the surgeon optimal visualization of pathogenic structures. This case series aims to report an initial assessment of the safety and efficacy of supraorbital craniotomy by blepharoplasty transpalpebral (eyelid) incision for surgical disconnection of ethmoidal dAVFs. METHODS:Retrospective chart review was conducted for all patients who underwent blepharoplasty incision and craniotomy for disconnection of ethmoidal dAVFs at our institution between October 2011 and February 2023. Patient charts and follow-up imaging were reviewed to report clinical and angiographic outcomes as well as periprocedural and follow-up complications. RESULTS:Complete obliteration and disconnection of ethmoidal dAVF was achieved in all 6 (100%) patients as confirmed by intraoperative angiogram with no resulting morbidity or mortality. Periprocedural complications included one case of transient nasal cerebrospinal fluid leak that was self-limiting and resolved before discharge without intervention. CONCLUSION/CONCLUSIONS:Surgical treatment for ethmoidal dAVFs, specifically by transpalpebral incision and supraorbital craniotomy, is a safe and effective treatment option and affords the surgeon greater access to the floor of the anterior fossa when necessary. In addition, blepharoplasty incision addressed patient concerns for facial scarring compared with other incision sites by creating a more well-hidden, minimal scar in the natural folds of the eyelid for patients with an eyelid crease.
PMID: 38376155
ISSN: 2332-4260
CID: 5634152

Bailout endovascular techniques applied in a complicated basilar thrombectomy case

Ali, Aryan; Shapiro, Maksim; Nossek, Erez; Esparza, Rogelio; Narayan, Vinayak; Sharashidze, Vera; Raz, Eytan
Patients with stroke symptoms due to acute basilar artery occlusion can benefit from endovascular thrombectomy.1 2 Several papers have reported unwanted events during thrombectomy procedures such as breakage, fragmentation, or even intravascular migration of the devices or catheter pieces. These papers also presented methods or techniques to retrieve defective devices such as a snare, retrievable stents, or balloons.3-6Video 1 presents a case of basilar thrombectomy that was complicated with fragmentation and then distal migration of a Marksman microcatheter tip into the left posterior cerebral artery. The video shows the bailout technique that was used to retrieve the migrated catheter tip using a gentle/simple and posterior circulation-friendly technique-a technique based on fundamental neurointerventional concepts.neurintsurg;jnis-2022-019687v1/V1F1V1Video 1 This video demonstrates the use of a bailout technique to retrieve a migrated microcatehter tip after basilar artery thrombectomy.
PMID: 37221037
ISSN: 1759-8486
CID: 5508362

Superior hypophyseal arteries: angiographic re-discovery, comprehensive assessment, and embryologic implications

Shapiro, Maksim; Sharashidze, Vera; Nossek, Erez; Sen, Chandra; Rutledge, Caleb; Chung, Charlotte; Khawaja, Ayaz; Kvint, Svetlana; Riina, Howard; Nelson, Peter Kim; Raz, Eytan
UNLABELLED:The superior hypophyseal arteries (SHAs) are well known in anatomical and surgical literature, with a well-established role in supply of the anterior hypophysis and superjacent optic apparatus. However, due to small size and overlap with other vessels, in vivo imaging by any modality has been essentially non-existent. Advances in high resolution cone beam CT angiography (CBCTA) now enables this deficiency to be addressed. This paper presents, to the best of our knowledge, the first comprehensive in vivo imaging evaluation of the SHAs. METHODS:Twenty-five CBCTA studies of common or internal carotid arteries were obtained for a variety of clinical reasons. Dedicated secondary reconstructions of the siphon were performed, recording the presence, number, and supply territory of SHAs. A spectrum approach, emphasizing balance with adjacent territories (inferior hypophyseal, ophthalmic, posterior and communicating region arteries) was investigated. RESULTS:The SHAs were present in all cases. Supply of the anterior pituitary was nearly universal (96%) and almost half (44%) originated from the 'cave' region, in excellent agreement with surgical literature. Optic apparatus supply was more difficult to adjudicate, but appeared present in most cases. The relationship with superior hypophyseal aneurysms was consistent. Patency following flow diverter placement was typical, despite a presumably rich collateral network. Embryologic implications with respect to the ophthalmic artery and infraoptic course of the anterior cerebral artery are intriguing. CONCLUSIONS:SHAs are consistently seen with CBCTA, allowing for correlation with existing anatomical and surgical literature, laying the groundwork for future in vivo investigation.
PMID: 37875341
ISSN: 1759-8486
CID: 5614322

COManeci MechANical dilation for vasospasm (COMMAND): multicenter experience

Salem, Mohamed M; Khalife, Jane; Desai, Sohum; Sharashidze, Vera; Badger, Clint; Kuhn, Anna L; Monteiro, Andre; Salahuddin, Hisham; Siddiqui, Adnan H; Singh, Jasmeet; Levy, Elad I; Lang, Michael; Grandhi, Ramesh; Thomas, Ajith J; Lin, Li-Mei; Tanweer, Omar; Burkhardt, Jan-Karl; Puri, Ajit S; Gross, Bradley A; Nossek, Erez; Hassan, Ameer E; Shaikh, Hamza A; Jankowitz, Brian T
BACKGROUND:We report the largest multicenter experience to date of utilizing the Comaneci device for endovascular treatment of refractory intracranial vasospasm. METHODS:Consecutive patients undergoing Comaneci mechanical dilatation for vasospasm were extracted from prospectively maintained registries in 11 North American centers (2020-2022). Intra-arterial vasodilators (IAV) were allowed, with the Comaneci device utilized after absence of vessel dilation post-infusion. Pre- and post-vasospasm treatment scores were recorded for each segment, with primary radiological outcome of score improvement post-treatment. Primary clinical outcome was safety/device-related complications, with secondary endpoints of functional outcomes at last follow-up. RESULTS:A total of 129 vessels in 40 patients (median age 52 years; 67.5% females) received mechanical dilation, 109 of which (84.5%) exhibited pre-treatment severe-to-critical vasospasm (ie, score 3/4). Aneurysmal subarachnoid hemorrhage was the most common etiology of vasospasm (85%), with 65% of procedures utilizing Comaneci-17 (92.5% of patients received IAV). The most treated segments were anterior cerebral artery (34.9%) and middle cerebral artery (31%). Significant vasospasm drop (pre-treatment score (3-4) to post-treatment (0-2)) was achieved in 89.9% of vessels (96.1% of vessels experienced ≥1-point drop in score post-treatment). There were no major procedural/post-procedural device-related complications. Primary failure (ie, vessel unresponsive) was encountered in one vessel (1 patient) (1/129; 0.8%) while secondary failure (ie, recurrence in previously treated segment requiring retreatment in another procedure) occurred in 16 vessels (7 patients) (16/129; 12.4%), with median time-to-retreatment of 2 days. Favorable clinical outcome (modified Rankin Scale 0-2) was noted in 51.5% of patients (median follow-up 6 months). CONCLUSIONS:The Comaneci device provides a complementary strategy for treatment of refractory vasospasm with reasonable efficacy/favorable safety. Future prospective trials are warranted.
PMID: 36002289
ISSN: 1759-8486
CID: 5338272

Update on Large-Vessel Revascularization in Acute Ischemic Stroke

Saini, Vasu; Sharashidze, Vera; Abecassis, Isaac Josh; Guada, Luis; Charles, Jude Hassan; Limaye, Kaustubh; Yavagal, Dileep R.
Purpose of review: This review presents the critical appraisal of current therapeutic strategies for patients with large-vessel occlusion (LVO) acute ischemic stroke (AIS). We provide the reader with most recent evidence supporting endovascular thrombectomy (EVT), different techniques used for thrombectomy, and highlight knowledge gaps regarding therapeutic efficacy of this intervention in respective subgroup of these patients based on site of occlusion, size of ischemic core, time from symptom onset, utility of concurrent intravenous thrombolysis (IVT), mild strokes, or tandem occlusions. Recent findings: EVT is the established standard of care for patients with moderate-severe LVO-AIS presenting within 24 h of symptom onset and favorable perfusion imaging irrespective of IVT. The DIRECT-MT and SKIP randomized clinical trials (RCT) established that EVT without IVT for eligible patients is not non-inferior to concurrent IVT. The RESCUE-Japan LIMIT randomized controlled trial showed EVT in patients with ASPECTS score of 3"“5 presenting within 6 h of symptom onset or within 24 h if no early ischemic change was seen on MRI FLAIR sequence. Good functional outcome at 90 days (mRS 0"“3) was seen in 31% patients undergoing EVT and only in 12.7% in the medical group (relative risk 2.43, 95%CI 1.35"“4.37, p = 0.002). Any ICH was notably higher in the EVT group (58% versus 31.4%, p < 0.001). The SELECT-2 RCT enrolled patients with CT ASPECTS of 3"“5, or CT or MR perfusion core > 50 cc. The mRS scores moved toward functionally independent survival, with a generalized odds ratio favoring thrombectomy of 1.51 (95% CI 1.20"“1.89; p < 0.001). In addition, a phase 2b, randomized, placebo-controlled clinical trial, CHOICE, showed that intraarterial administration of alteplase (0.225 mg/kg; maximum dose 22.5 mg) after successful EVT (TICI 2b"“3) led to 18.6% increase (adjusted risk difference) in excellent functional outcomes at 90 days (59% versus 40.4%, 95% CI 0.3"“36.4%, p = 0.047). Summary: The industry has kept pace with the evolving needs and optimizing devices to achieve desired procedural efficacy for EVT resulting in great functional outcomes. We continue to explore the means to expand the indication and eligibility of patients suffering from LVO-AIS who would benefit from this life-saving procedure.
SCOPUS:85163790890
ISSN: 1092-8480
CID: 5548442

Principles, techniques and applications of high resolution cone beam CT angiography in the neuroangio suite

Raz, Eytan; Nossek, Erez; Sahlein, Daniel H; Sharashidze, Vera; Narayan, Vinayak; Ali, Aryan; Esparza, Rogelio; Peschillo, Simone; Chung, Charlotte; Diana, Francesco; Syed, Safia; Nelson, Peter Kim; Shapiro, Maksim
The aim of this review is to describe the acquisition and reformatting of state of the art high resolution cone beam CT (HR-CBCT) and demonstrate its role in multiple neurovascular conditions as a tool to improve the understanding of disease and guide therapeutic decisions. First, we will review the basic principle of CBCT acquisition, followed by the injection protocols and the reformatting paradigms. Next, multiple applications in different pathological conditions such as aneurysms, arteriovenous malformations, dural arteriovenous fistulas, and stroke will be described. HR-CBCT angiography, widely available, is uniquely useful in certain clinical scenarios to improve the understanding of disease and guide therapeutic decisions. It rapidly is becoming an essential tool for the contemporary neurointerventionalist.AChoAho.
PMID: 35835462
ISSN: 1759-8486
CID: 5269382

Social Media in Stroke Career Development

McAree, Michael; Sharashidze, Vera
PMID: 37139819
ISSN: 1524-4628
CID: 5503082

Cerebral venous anatomy: implications for the neurointerventionalist

Shapiro, Maksim; Raz, Eytan; Nossek, Erez; Srivatanakul, Kittipong; Young, Matthew; Narayan, Vinayak; Ali, Aryan; Sharashidze, Vera; Esparza, Rogelio; Nelson, Peter Kim
Meaningful contributions to neurointerventional practice may be possible by considering the dynamic aspects of angiography in addition to fixed morphologic information. The functional approach to venous anatomy requires integration of the traditional static anatomic features of the system-deep, superficial, posterior fossa, medullary veins, venous sinuses, and outflow routes into an overall appreciation of how a classic model of drainage is altered, embryologically, or pathologically, depending on patterns of flow-visualization made possible by angiography. In this review, emphasis is placed on balance between alternative venous networks and their redundancy, and the problems which arise when these systems are lacking. The role of veins in major neurovascular diseases, such as dural arteriovenous fistulae, arteriovenous malformations, pulsatile tinnitus, and intracranial hypertension, is highlighted, and deficiencies in knowledge emphasized.
PMID: 35803732
ISSN: 1759-8486
CID: 5280692

An unusual anatomical variant: A transclival artery supplying the vertebrobasilar circulation

Raz, Eytan; Nayak, Gopi; Sharashidze, Vera; Nossek, Erez; Malak, Wassim; Bueno, Hugo; Komiyama, Masaki; Nelson, Peter Kim; Shapiro, Maksim
The persistent carotid-vertebrobasilar anastomoses are arterial communications between the anterior and posterior circulations due to the persistence of embryological connections. We here present an extremely rare instance of a transclival persistent carotid-vertebrobasilar anastomosis in a 10-month-old infant, which does not fit into any of the traditionally described categories, such as the trigeminal artery, hypoglossal artery, or proatlantal artery.
PMID: 37032452
ISSN: 2385-2011
CID: 5464012