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Preoperative Risk and the Association between Hypotension and Postoperative Acute Kidney Injury

Mathis, Michael R; Naik, Bhiken I; Freundlich, Robert E; Shanks, Amy M; Heung, Michael; Kim, Minjae; Burns, Michael L; Colquhoun, Douglas A; Rangrass, Govind; Janda, Allison; Engoren, Milo C; Saager, Leif; Tremper, Kevin K; Kheterpal, Sachin; Aziz, Michael F; Coffman, Traci; Durieux, Marcel E; Levy, Warren J; Schonberger, Robert B; Soto, Roy; Wilczak, Janet; Berman, Mitchell F; Berris, Joshua; Biggs, Daniel A; Coles, Peter; Craft, Robert M; Cummings, Kenneth C; Ellis, Terri A; Fleishut, Peter M; Helsten, Daniel L; Jameson, Leslie C; van Klei, Wilton A; Kooij, Fabian; LaGorio, John; Lins, Steven; Miller, Scott A; Molina, Susan; Nair, Bala; Paganelli, William C; Peterson, William; Tom, Simon; Wanderer, Jonathan P; Wedeven, Christopher
WHAT WE ALREADY KNOW ABOUT THIS TOPIC/UNASSIGNED:Acute kidney injury occurs in 13% of patients undergoing major surgery and is associated with a six-fold increased risk of mortality.Single-center studies have demonstrated an association between intraoperative hypotension and acute kidney injury. WHAT THIS ARTICLE TELLS US THAT IS NEW/UNASSIGNED:In a large cohort of noncardiac surgical patients, the incidence of acute kidney injury was 9%.Major factors identifying patients at risk for acute kidney injury included anemia, estimated glomerular filtration rate, elevated risk surgery, American Society of Anesthesiologists Physical Status, and expected anesthesia duration.The relationship between hypotension and acute kidney injury varied by underlying patient and procedural risk. Patients with low risk demonstrated no associated increased risk of acute kidney injury across all blood pressure ranges, whereas patients with the highest baseline risk demonstrated an association between even mild absolute intraoperative hypotension ranges and acute kidney injury. BACKGROUND:Despite the significant healthcare impact of acute kidney injury, little is known regarding prevention. Single-center data have implicated hypotension in developing postoperative acute kidney injury. The generalizability of this finding and the interaction between hypotension and baseline patient disease burden remain unknown. The authors sought to determine whether the association between intraoperative hypotension and acute kidney injury varies by preoperative risk. METHODS:Major noncardiac surgical procedures performed on adult patients across eight hospitals between 2008 and 2015 were reviewed. Derivation and validation cohorts were used, and cases were stratified into preoperative risk quartiles based upon comorbidities and surgical procedure. After preoperative risk stratification, associations between intraoperative hypotension and acute kidney injury were analyzed. Hypotension was defined as the lowest mean arterial pressure range achieved for more than 10 min; ranges were defined as absolute (mmHg) or relative (percentage of decrease from baseline). RESULTS:Among 138,021 cases reviewed, 12,431 (9.0%) developed postoperative acute kidney injury. Major risk factors included anemia, estimated glomerular filtration rate, surgery type, American Society of Anesthesiologists Physical Status, and expected anesthesia duration. Using such factors and others for risk stratification, patients with low baseline risk demonstrated no associations between intraoperative hypotension and acute kidney injury. Patients with medium risk demonstrated associations between severe-range intraoperative hypotension (mean arterial pressure less than 50 mmHg) and acute kidney injury (adjusted odds ratio, 2.62; 95% CI, 1.65 to 4.16 in validation cohort). In patients with the highest risk, mild hypotension ranges (mean arterial pressure 55 to 59 mmHg) were associated with acute kidney injury (adjusted odds ratio, 1.34; 95% CI, 1.16 to 1.56). Compared with absolute hypotension, relative hypotension demonstrated weak associations with acute kidney injury not replicable in the validation cohort. CONCLUSIONS:Adult patients undergoing noncardiac surgery demonstrate varying associations with distinct levels of hypotension when stratified by preoperative risk factors. Specific levels of absolute hypotension, but not relative hypotension, are an important independent risk factor for acute kidney injury.
PMID: 31794513
ISSN: 1528-1175
CID: 4218352

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review

Larach, Marilyn Green; Klumpner, Thomas T; Brandom, Barbara W; Vaughn, Michelle T; Belani, Kumar G; Herlich, Andrew; Kim, Tae W; Limoncelli, Janine; Riazi, Sheila; Sivak, Erica L; Capacchione, John; Mashman, Darlene; Kheterpal, Sachin; Kooij, Fabian; Wilczak, Janet; Soto, Roy; Berris, Joshua; Price, Zachary; Lins, Steven; Coles, Peter; Harris, John M; Cummings, Kenneth C; Berman, Mitchell F; Nanamori, Masakatsu; Adelman, Bruce T; Wedeven, Christopher; LaGorio, John; McCormick, Patrick J; Tom, Simon; Aziz, Michael F; Coffman, Traci; Ellis, Terri A; Molina, Susan; Peterson, William; Mackey, Sean C; van Klei, Wilton A; Ginde, Adit A; Biggs, Daniel A; Neuman, Mark D; Craft, Robert M; Pace, Nathan L; Paganelli, William C; Durieux, Marcel E; Nair, Bala J; Wanderer, Jonathan P; Miller, Scott A; Helsten, Daniel L; Turnbull, Zachary A; Schonberger, Robert B
WHAT WE ALREADY KNOW ABOUT THIS TOPIC/UNASSIGNED:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality. METHODS:The authors performed focused analyses of the Multicenter Perioperative Outcomes Group (2005 through 2016), North American MH Registry (2013 through 2016), and Anesthesia Closed Claims Project (1970 through 2014) databases, as well as a systematic literature review (1987 through 2017). The authors used difficult mask ventilation (grades III and IV) as a surrogate for airway rescue. MH experts judged dantrolene treatment. For MH morbidity/mortality analyses, the authors included U.S. and Canadian cases that were fulminant or scored 20 or higher on the clinical grading scale and in which volatile anesthetics or succinylcholine were given. RESULTS:Among 6,368,356 queried outcomes cases, 246,904 (3.9%) received succinylcholine without volatile agents. Succinylcholine was used in 46% (n = 710) of grade IV mask ventilation cases (median dose, 100 mg, 1.2 mg/kg). Succinylcholine without volatile anesthetics triggered 24 MH cases, 13 requiring dantrolene. Among 310 anesthetic-triggered MH cases, morbidity was 20 to 37%. Treatment delay increased complications every 10 min, reaching 100% with a 50-min delay. Overall mortality was 1 to 10%; 15 U.S. patients died, including 4 after anesthetics in freestanding facilities. CONCLUSIONS:Providers use succinylcholine commonly, including during difficult mask ventilation. Succinylcholine administered without volatile anesthetics may trigger MH events requiring dantrolene. Delayed dantrolene treatment increases the likelihood of MH complications. The data reported herein support stocking dantrolene wherever succinylcholine or volatile anesthetics may be used.
PMID: 30550426
ISSN: 1528-1175
CID: 3556382

Risk of Epidural Hematoma after Neuraxial Techniques in Thrombocytopenic Parturients: A Report from the Multicenter Perioperative Outcomes Group

Lee, Linden O; Bateman, Brian T; Kheterpal, Sachin; Klumpner, Thomas T; Housey, Michelle; Aziz, Michael F; Hand, Karen W; MacEachern, Mark; Goodier, Christopher G; Bernstein, Jeffrey; Bauer, Melissa E; Lirk, Philip; Wilczak, Janet; Soto, Roy; Tom, Simon; Cuff, Germaine; Biggs, Daniel A; Coffman, Traci; Saager, Leif; Levy, Warren J; Godbold, Michael; Pace, Nathan L; Wethington, Kevin L; Paganelli, William C; Durieux, Marcel E; Domino, Karen B; Nair, Bala; Ehrenfeld, Jesse M; Wanderer, Jonathan P; Schonberger, Robert B; Berris, Joshua; Lins, Steven; Coles, Peter; Cummings, Kenneth C; Maheshwari, Kamal; Berman, Mitchell F; Wedeven, Christopher; LaGorio, John; Fleishut, Peter M; Ellis, Terri A 2nd; Molina, Susan; Carl, Curtis; Kadry, Bassam; van Klei, Wilton A; Pasma, Wietze; Jameson, Leslie C; Helsten, Daniel L; Avidan, Michael S
BACKGROUND: Thrombocytopenia has been considered a relative or even absolute contraindication to neuraxial techniques due to the risk of epidural hematoma. There is limited literature to estimate the risk of epidural hematoma in thrombocytopenic parturients. The authors reviewed a large perioperative database and performed a systematic review to further define the risk of epidural hematoma requiring surgical decompression in this population. METHODS: The authors performed a retrospective cohort study using the Multicenter Perioperative Outcomes Group database to identify thrombocytopenic parturients who received a neuraxial technique and to estimate the risk of epidural hematoma. Patients were stratified by platelet count, and those requiring surgical decompression were identified. A systematic review was performed, and risk estimates were combined with those from the existing literature. RESULTS: A total of 573 parturients with a platelet count less than 100,000 mm who received a neuraxial technique across 14 institutions were identified in the Multicenter Perioperative Outcomes Group database, and a total of 1,524 parturients were identified after combining the data from the systematic review. No cases of epidural hematoma requiring surgical decompression were observed. The upper bound of the 95% CI for the risk of epidural hematoma for a platelet count of 0 to 49,000 mm is 11%, for 50,000 to 69,000 mm is 3%, and for 70,000 to 100,000 mm is 0.2%. CONCLUSIONS: The number of thrombocytopenic parturients in the literature who received neuraxial techniques without complication has been significantly increased. The risk of epidural hematoma associated with neuraxial techniques in parturients at a platelet count less than 70,000 mm remains poorly defined due to limited observations.
PMID: 28383323
ISSN: 1528-1175
CID: 2521572