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Change in gliding properties of the iliotibial tract in hypermobile Ehlers-Danlos Syndrome

Wang, Tina J; Stecco, Antonio; Schleip, Robert; Stecco, Carla; Pirri, Carmelo
PURPOSE/OBJECTIVE:Fascial changes in hypermobile Ehlers-Danlos syndrome (hEDS), a heritable connective tissue disorder, can be used visualized with sonoelastography. The purpose of this study was to explore the inter-fascial gliding characteristics in hEDS. METHODS:In 9 subjects, the right iliotibial tract was examined with ultrasonography. Tissue displacements of the iliotibial tract were estimated from ultrasound data using cross-correlation techniques. RESULTS:In hEDS subjects, shear strain was 46.2%, lower than those with lower limb pain without hEDS (89.5%) and in control subjects without hEDS and without pain (121.1%). CONCLUSION/CONCLUSIONS:Extracellular matrix changes in hEDS may manifest as reduced inter-fascial plane gliding.
PMID: 36802027
ISSN: 1876-7931
CID: 5433732

Hyaluronan Homeostasis and its Role in Pain and Muscle Stiffness

Amir, Adam; Kim, Soo; Stecco, Antonio; Jankowski, Michael P; Raghavan, Preeti
PMID: 35077007
ISSN: 1934-1563
CID: 5154382

Ultrasound imaging and Fascial Manipulation® for rigid retinacula in two cases of complex regional pain syndrome [Case Report]

Pirri, Carmelo; Stecco, Antonio; Stecco, Carla; Özçakar, Levent
Complex regional Pain Syndrome (CRPS) is a complex disease with articulate impact on the quality of life and its management is challenging. Ultrasound imaging can identify/assess different musculoskeletal structures that might have role in its pathogenesis. We present two cases of CRSP in whom B-mode ultrasonography and sonoelastography showed rigid retinacula associated with the symptomatology. Both patients were also/successfully treated with Fascial Manipulation®.
PMID: 34379713
ISSN: 2066-8643
CID: 5331292

Facial Pain: RCT between Conventional Treatment and Fascial Manipulation® for Temporomandibular Disorders

Sekito, Florence; Pintucci, Marco; Pirri, Carmelo; Ribeiro de Moraes Rego, Mariana; Cardoso, Mayra; Soares Paixão, Kenia; Ribeiro da Silva, Valquiria; Stecco, Antonio
BACKGROUND:(FM), in comparison with conventional treatments in temporomandibular disorders (TMD) patients using a two-arm randomized controlled trial. METHODS:vs. Group 2: conventional TMD treatment). The Verbal Rating Scale (VRS), RDC/TMD, electromyography (EMG) and Pression/Pain Evaluation on Masseter and Temporalis Muscle were assessed with different times. RESULTS:= 0.001). CONCLUSIONS:can be used as an effective method for facial pain, being a rapid, safe and cost-effective approach to reduce pain, gain function and mouth opening that can be used prior to occlusion stabilization appliances.
PMID: 35877330
ISSN: 2306-5354
CID: 5276242

Densification: Hyaluronan Aggregation in Different Human Organs

Stecco, Antonio; Cowman, Mary; Pirri, Nina; Raghavan, Preeti; Pirri, Carmelo
Hyaluronan (HA) has complex biological roles that have catalyzed clinical interest in several fields of medicine. In this narrative review, we provide an overview of HA aggregation, also called densification, in human organs. The literature suggests that HA aggregation can occur in the liver, eye, lung, kidney, blood vessel, muscle, fascia, skin, pancreatic cancer and malignant melanoma. In all these organs, aggregation of HA leads to an increase in extracellular matrix viscosity, causing stiffness and organ dysfunction. Fibrosis, in some of these organs, may also occur as a direct consequence of densification in the long term. Specific imaging evaluation, such dynamic ultrasonography, elasto-sonography, elasto-MRI and T1ρ MRI can permit early diagnosis to enable the clinician to organize the treatment plan and avoid further progression of the pathology and dysfunction.
PMID: 35447719
ISSN: 2306-5354
CID: 5218542

Fascial thickness and stiffness in hypermobile Ehlers-Danlos syndrome

Wang, Tina J; Stecco, Antonio
There is a high prevalence of myofascial pain in people with hypermobile Ehlers-Danlos Syndrome (hEDS). The fascial origin of pain may correspond to changes in the extracellular matrix. The objective of this study was to investigate structural changes in fascia in hEDS. A series of 65 patients were examined prospectively-26 with hEDS, and 39 subjects with chronic neck, knee, or back pain without hEDS. The deep fascia of the sternocleidomastoid, iliotibial tract, and iliac fascia were examined with B-mode ultrasound and strain elastography, and the thicknesses were measured. Stiffness (strain index) was measured semi-quantitatively using elastography comparing fascia to muscle. Differences between groups were compared using one-way analysis of variance. hEDS subjects had a higher mean thickness in the deep fascia of the sternocleidomastoid compared with non-hEDS subjects. There was no significant difference in thickness of the iliac fascia and iliotibial tract between groups. Non-hEDS subjects with pain had a higher strain index (more softening of the fascia with relative stiffening of the muscle) compared with hEDS subjects and non-hEDS subjects without back or knee pain. In myofascial pain, softening of the fascia may occur from increase in extracellular matrix content and relative increase in stiffness of the muscle; this change is not as pronounced in hEDS.
PMID: 34741592
ISSN: 1552-4876
CID: 5068342

Ultrasound Imaging of Crural Fascia and Epimysial Fascia Thicknesses in Basketball Players with Previous Ankle Sprains Versus Healthy Subjects

Pirri, Carmelo; Fede, Caterina; Stecco, Antonio; Guidolin, Diego; Fan, Chenglei; De Caro, Raffaele; Stecco, Carla
BACKGROUND:Fascial layers may play an important role in locomotor mechanics. Recent researches have revealed an association between increases of fascia thickness and reduced joint flexibility in patients with chronic pain. The purpose of this study was to measure and compare, through the use of ultrasound imaging, the thickness of the deep/crural fascia in different points of the leg as well as the epimysial fascia thickness at level 2 of anterior compartment of leg, in male basketball players with history of recurrent ankle sprain and in healthy participants. METHODS:A cross-sectional study has been performed using ultrasound imaging to measure deep/crural fascia thickness of anterior, lateral and posterior compartment of the leg at different levels with a new protocol in a sample of 30 subjects, 15 basketball players and 15 healthy participants. RESULTS:< 0.001) were decreased showing statistically significant difference for the basketball players group respect the healthy participants group. CONCLUSIONS:These findings suggested that the posterior compartment was thicker than anterior compartment, probably due to a postural reason in both groups. Moreover, they showed an increase of thickness of the epimysial fascia in basketball players with previous ankle sprains. This variability underlines the importance to assess the fasciae and to make results comparable.
PMID: 33530583
ISSN: 2075-4418
CID: 4776322

Fascial or Muscle Stretching? A Narrative Review [Review]

Stecco, Carla; Pirri, Carmelo; Fede, Caterina; Yucesoy, Can A.; De Caro, Raffaele; Stecco, Antonio
ISSN: 2076-3417
CID: 4773492

The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome [Case Report]

Wang, Tina J; Stecco, Antonio; Dashtipour, Khashayar
Background/UNASSIGNED:Many patients with hypermobile Ehlers-Danlos Syndrome (EDS) suffer from cervical dystonia. Intramuscular injection of botulinum toxin may exacerbate myeloradiculopathy or atlantoaxial subluxation in this patient population. Case/UNASSIGNED:Three patients with hypermobile EDS underwent low-dose OnabotulinumtoxinA injections for cervical dystonia into myofascial sites selected using Fascial Manipulation diagnostic sequencing technique. All patients improved in clinical symptoms without complications. Results/UNASSIGNED:Patients clinically improved on the TWSTRS by 16 points with demonstrated changes in deep fascia thickness decrease of 0.28 mm. Discussion/UNASSIGNED:Low-dose OnabotulinumtoxinA injections into carefully selected sites is a safe and effective treatment in hypermobile EDS patients suffering from cervical dystonia.
PMID: 34754601
ISSN: 2160-8288
CID: 5050442

Myofascial Injection Using Fascial Layer-Specific Hydromanipulation Technique (FLuSH) and the Delineation of Multifactorial Myofascial Pain

Wang, Tina; Vahdatinia, Roya; Humbert, Sarah; Stecco, Antonio
Background and objectives: The aims of this study were to delineate the contribution of specific fascial layers of the myofascial unit to myofascial pain and introduce the use of ultrasound-guided fascial layer-specific hydromanipulation (FLuSH) as a novel technique in the treatment of myofascial pain. Materials and Methods: The clinical data of 20 consecutive adult patients who underwent myofascial injections using FLuSH technique for the treatment of myofascial pain were reviewed. The FLuSH technique involved measuring the pain pressure threshold using an analog algometer initially and after each ultrasound guided injection of normal saline into the specific layers of the myofascial unit (superficial fascia, deep fascia, or muscle) in myofascial points corresponding with Centers of Coordination/Fusion (Fascial Manipulation®). The outcome measured was the change in pain pressure threshold after injection of each specific fascial layer. Results: Deep fascia was involved in 73%, superficial fascia in 55%, and muscle in 43% of points. A non-response to treatment of all three layers occurred in 10% of all injected points. The most common combinations of fascial layer involvement were deep fascia alone in 23%, deep fascia and superficial fascia in 22%, and deep fascia and muscle in 18% of injected points. Each individual had on average of 3.0 ± 1.2 different combinations of fascial layers contributing to myofascial pain. Conclusions: The data support the hypothesis that multiple fascial layers are responsible for myofascial pain. In particular, for a given patient, pain may develop from discrete combinations of fascial layers unique to each myofascial point. Non-response to treatment of the myofascial unit may represent a centralized pain process. Adequate treatment of myofascial pain may require treatment of each point as a distinct pathologic entity rather than uniformly in a given patient or across patients.
PMID: 33419263
ISSN: 1648-9144
CID: 4746292