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A comparison of gatifloxacin to ciprofloxacin in the prophylaxis of Streptococcus pneumoniae in rabbits in a LASIK model

Donnenfeld, Robert S; Perry, Henry D; Solomon, Renee; Jensen, Harold G; Stein, Jonathan; Snyder, Robert W; Wittpenn, John R; Donnenfeld, Eric D
PURPOSE: To investigate the efficacy of the fourth-generation fluoroquinolone, gatifloxacin 0.3%, compared to ciprofloxacin 0.3%, in preventing Streptococcus pneumoniae keratitis in a rabbit laser in situ keratomileusis (LASIK) model. METHODS: Twelve albino rabbits had bilateral lamellar flaps created. Group A (eight eyes) was given gatifloxacin 0.3%; group B (eight eyes) was given ciprofloxacin 0.3%; and group C (eight eyes) served as the controls. Groups A and B received one drop of antibiotic 20 minutes before the creation of the lamellar flap, at the conclusion of flap formation, and four times per day for 3 days. All corneas were inoculated with 0.1 mL of 4 x 10 organisms/mL of S. pneumoniae immediately after flap formation. On day 3, all corneas were examined and cultured. RESULTS: Group A (gatifloxacin) had no infiltrates and three areas of 1-mm central corneal haze. On day 3, one of eight corneas had a positive culture. Group B (ciprofloxacin) had seven infiltrates, including one perforation, and six of eight corneas had positive cultures. Group C (control) had eight corneal infiltrates, and all eight corneas had positive cultures. The data show a statistically significant difference between gatifloxacin and ciprofloxacin and gatifloxacin and control for mean infiltrate size and mean culture scores. CONCLUSIONS: The fourth-generation fluoroquinolone, topical gatifloxacin 0.3%, is superior to topical ciprofloxacin 0.3% for prophylaxis against a clinical isolate of S. pneumoniae in a rabbit LASIK model
PMID: 16415694
ISSN: 1542-2321
CID: 80439

Penetration of topically applied gatifloxacin 0.3%, moxifloxacin 0.5%, and ciprofloxacin 0.3% into the aqueous humor

Solomon, Renee; Donnenfeld, Eric D; Perry, Henry D; Snyder, Robert W; Nedrud, Chad; Stein, Jonathan; Bloom, Adam
PURPOSE: To investigate the aqueous penetration of 3 commercially available ophthalmic fluoroquinolones. DESIGN: Prospective, double-masked, clinical study. PARTICIPANTS: Fifty-two eyes of 52 patients. INTERVENTION: Fifty-two patients undergoing cataract surgery were given preoperative topical gatifloxacin 0.3% (Zymar), moxifloxacin 0.5% (Vigamox), or ciprofloxacin 0.3% (Ciloxan). The patients were instructed to use their antibiotic drops 4 times a day for 3 days before surgery. On the day of surgery, patients were given their assigned antibiotic every 15 minutes for 3 doses, 1 hour before their procedure. At the time of surgery, 0.1 ml of aqueous fluid was aspirated from the anterior chamber with an air cannula needle attached to a tuberculin syringe. The aspirate was immediately stored at -70 degrees C. MAIN OUTCOME MEASURE: Fluoroquinolone concentrations were determined by reverse-phase high-pressure liquid chromatography assay technique with ultraviolet detection at a wavelength of 275 nm. RESULTS: Mean aqueous concentration of gatifloxacin in 16 eyes was 0.63 microg/ml (standard deviation [SD], 0.30), moxifloxacin in 14 eyes was 1.31 microg/ml (SD, 0.46), and the mean concentration of ciprofloxacin in 22 eyes was 0.15 microg/ml (SD, 0.11). CONCLUSIONS: Both moxifloxacin (P<0.001) and gatifloxacin (P<0.005) penetrated the aqueous humor at significantly higher levels than ciprofloxacin. Moxifloxacin penetrated into the aqueous humor at significantly higher levels than gatifloxacin (P<0.05). The anterior chamber levels of moxifloxacin and gatifloxacin may be due to the difference in antibiotic concentration
PMID: 15745775
ISSN: 1549-4713
CID: 80449

Hyperopic photorefractive keratectomy with adjunctive topical mitomycin C for refractive error after penetrating keratoplasty for keratoconus [Case Report]

Solomon, Renee; Donnenfeld, Eric D; Thimons, James; Stein, Jonathan; Perry, Henry D
OBJECTIVE: To present a case of photorefractive keratectomy (PRK) with adjunctive topical mitomycin C (MMC) in an anisometropic hyperopic patient after penetrating keratoplasty (PKP) for keratoconus. METHODS: Interventional case report, chart review, and literature review. RESULTS: A 43-year-old man with a refraction of +7.00 -4.75 x 125 in the right eye underwent PRK 10 months after PKP for keratoconus. The patient had sutures removed for 3 months and was intolerant of contact lenses. After photoablation, 0.02% MMC was applied to the corneal stromal bed. The patient was followed up daily until the epithelium closed and at 1 week, 1 month, 3 months, and 6 months postoperatively. CONCLUSIONS: To our knowledge, this represents the first reported case of the use of MMC to prevent postoperative haze after PRK for PKP in an eye with keratoconus. MMC (0.02%) applied topically to the cornea immediately after PRK is safe and effective to treat a hyperopic refractive error after PKP and prevent postoperative corneal haze formation without the risks of performing a lamellar flap into an ectatic corneal bed
PMID: 15499236
ISSN: 1542-2321
CID: 80452

Dodick laser photolysis cataract extraction experience of ophthalmology residents at Manhattan Eye Ear and Throat Hospital [Meeting Abstract]

Glavas, IP; Miller, AI; Pettinelli, D; Shrier, E; Stein, JJ; Ali, I
ISSN: 0146-0404
CID: 55414

Post-operative results with implantation of the acrysof SA-60 intraocular lens into the ciliary sulcus [Meeting Abstract]

Kleiman, LZ; Glavas, IP; Stein, JJ; Jacobson, LM
ISSN: 0146-0404
CID: 55479

Initial clinical experience with the accomodating intraocular lens following cataract surgery [Meeting Abstract]

Miller, AI; Pettinell, DJ; Stein, JJ; Kanellopoulos, A
ISSN: 0146-0404
CID: 55480

Initial clinical experience with the wavelight ALLEGRETTO-WAVE Excimer laser in 287 consecutive myopic eyes treated with LASIK [Meeting Abstract]

Stein, JJ; Miller, AI; Pettinelli, DJ; Kanellopoulos, A
ISSN: 0146-0404
CID: 55489

Comparison of pre- and post-LASIK high order aberrations and coma with the wavelight ALLEGRETTO-WAVE laser in non wavefront-guided procedures and measured by the wavelight ALLEGRETTO aberrometer in 85 consecutive eyes [Meeting Abstract]

Pettinelli, DJ; Miller, AI; Stein, JJ; Kanellopoulos, A
ISSN: 0146-0404
CID: 55490

Comparison of the wavelight ALLEGRETTO-WAVE aberrometer to subjective refraction data in pre-operative evaluation of LASIK candidates [Meeting Abstract]

Tai, A; Stein, J; Miller, A; Pettinelli, D; Kanellopoulos, A
ISSN: 0146-0404
CID: 55491

Effect of variable tinted spectacle lenses on visual performance in control subjects

Lee, Jason E; Stein, Jonathan J; Prevor, Meredith B; Seiple, William H; Holopigian, Karen; Greenstein, Vivienne C; Stenson, Susan M
PURPOSE: To evaluate quantitatively the effects of tinted spectacle lenses on visual performance in individuals without visual pathology. METHODS: Twenty-five subjects were assessed by measuring contrast sensitivity with and without glare. Gray, brown, yellow, green, purple, and blue lens tints were evaluated. Measurements were repeated with each lens tint and with a clear lens, and the order was counterbalanced within and between subjects. Glare was induced with a modified brightness acuity tester. RESULTS: All subjects demonstrated an increase in contrast thresholds under glare conditions for all lens tints. However, purple and blue lens tints resulted in the least amount of contrast threshold increase; the yellow lens tint resulted in the largest contrast threshold increase. CONCLUSIONS: Purple and blue lens tints may improve contrast sensitivity in control subjects under glare conditions
PMID: 12054376
ISSN: 0733-8902
CID: 37709