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Split liver transplantation with extended right grafts on adult recipients: A propensity score matching analysis

Vargas, Paola A; Dalzell, Christina; Robinson, Todd; Cunningham, Michaela; Henry, Zachary; Stotts, Matthew J; Su, Feng; Argo, Curtis; Pelletier, Shawn; Oberholzer, Jose; Goldaracena, Nicolas
INTRODUCTION/BACKGROUND:Split liver transplantation (SLT) emerged due to its potential to contribute to the organ pool and reduce organ shortage. However, SLT is technically challenging and has been associated with higher rates of postoperative complications leading to concerns about graft and patient survival. Moreover, there are few studies on matched-pair adult recipients of SLT and whole-liver transplant (WLT), with conflicting results. METHODS:This retrospective study analyze outcomes among adults who underwent SLT at our institution from 2010 to 2019. A 1:1 propensity score matching analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes were analyzed and compared between groups. Actuarial graft and patient survival were analyzed by KM curves. RESULTS:Out of 592 adults receiving a LT in our institution, 21 SLT adult recipients were identified and matched with 21 adults undergoing WLT. As expected donor age was significantly lower in SLT recipients (16 (15-22) vs. 32 (17-47), P = .012). Additional donor characteristics, including anthropometrics, and ischemic times were similar between groups. Baseline recipient characteristics and postoperative outcomes, including length of stay, vascular complications, biliary complications, and re-transplantation were comparable between SLT and WLT recipients. Graft (95/95/95 vs. 100/94/94, P = .98) and patient (100/100/100 vs. 100/94/94, P = .30) survival at 1-, 3-, 5-years, were similar between the SLT- and WLT group, respectively. CONCLUSION/CONCLUSIONS:Split liver transplantation has the potential to increase the availability of organs for adult recipients without compromising individual outcomes.
PMID: 35997030
ISSN: 1399-0012
CID: 5339012

Outcomes in Adult Liver Transplant Recipients Using Pediatric Deceased Donor Liver Grafts

Vargas, Paola A; Wang, Haowei; Dalzell, Christina; Argo, Curtis; Henry, Zachary; Su, Feng; Stotts, Matthew J; Northup, Patrick; Oberholzer, Jose; Pelletier, Shawn; Goldaracena, Nicolas
Background/UNASSIGNED:The use of pediatric grafts for liver transplantation (LT) into adult recipients is rare, and reported outcomes are conflicting. The aim of this study is to evaluate the outcomes in adult recipients following LT with grafts from deceased pediatric donors. Methods/UNASSIGNED:A retrospective study identifying adult LT between 2010 and 2020 using pediatric deceased donor liver grafts was conducted. Adults undergoing LT with deceased donor pediatric grafts (age ≤ 12) were identified and matched 1:2 with adults receiving adult grafts (age ≥ 18) based on recipient age (±10 y), model for end-stage liver disease (MELD) score at transplant (±5 points) and etiology of liver disease. To assess real liver size differences between the pediatric-donor and adult-donor groups, patients receiving a graft from a donor between 13 and 17 y were excluded from the main analysis and studied independently. Outcomes between the groups were compared. Complication rates were identified and graded using Clavien-Dindo classification. Graft and patient survival were assessed by Kaplan-Meier curves. Results/UNASSIGNED: = 0.48). Conclusions/UNASSIGNED:Excellent patient and graft survival is achievable with LT using young pediatric deceased donor grafts in smaller adult recipients. Outcomes are comparable with recipients of age and MELD-matched adult donors. Careful donor MELD-score recipient matching and close monitoring for potential biliary and vascular complications are crucial to achieve acceptable outcomes.
PMCID:8989770
PMID: 35415214
ISSN: 2373-8731
CID: 5339002