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In women aged 45 to 75 y, opt-out vs. opt-in breast cancer screening outreach did not increase mammography rates

Tanner, Michael
Marcotte LM, Deeds S, Wheat C, et al. Automated opt-out vs opt-in patient outreach strategies for breast cancer screening: a randomized clinical trial. JAMA Intern Med. 2023;183:1187-1194. 37695621.
PMID: 38316001
ISSN: 1539-3704
CID: 5632762

In noncardiac surgery, hypotension- vs. hypertension-avoidance strategies did not differ for 30-d major vascular complications [Comment]

Tanner, Michael
Marcucci M, Painter TW, Conen D, et al; POISE-3 Trial Investigators and Study Groups. Hypotension-avoidance versus hypertension-avoidance strategies in noncardiac surgery: an international randomized controlled trial. Ann Intern Med. 2023;176:605-614. 37094336.
PMID: 37523699
ISSN: 1539-3704
CID: 5595292

Implementation fidelity to a behavioral diabetes prevention intervention in two New York City safety net primary care practices

Gupta, Avni; Hu, Jiyuan; Huang, Shengnan; Diaz, Laura; Gore, Radhika; Levy, Natalie; Bergman, Michael; Tanner, Michael; Sherman, Scott E; Islam, Nadia; Schwartz, Mark D
BACKGROUND:It is critical to assess implementation fidelity of evidence-based interventions and factors moderating fidelity, to understand the reasons for their success or failure. However, fidelity and fidelity moderators are seldom systematically reported. The study objective was to conduct a concurrent implementation fidelity evaluation and examine fidelity moderators of CHORD (Community Health Outreach to Reduce Diabetes), a pragmatic, cluster-randomized, controlled trial to test the impact of a Community Health Workers (CHW)-led health coaching intervention to prevent incident type 2 Diabetes Mellitus in New York (NY). METHODS:We applied the Conceptual Framework for Implementation Fidelity to assess implementation fidelity and factors moderating it across the four core intervention components: patient goal setting, education topic coaching, primary care (PC) visits, and referrals to address social determinants of health (SDH), using descriptive statistics and regression models. PC patients with prediabetes receiving care from safety-net patient-centered medical homes (PCMHs) at either, VA NY Harbor or at Bellevue Hospital (BH) were eligible to be randomized into the CHW-led CHORD intervention or usual care. Among 559 patients randomized and enrolled in the intervention group, 79.4% completed the intake survey and were included in the analytic sample for fidelity assessment. Fidelity was measured as coverage, content adherence and frequency of each core component, and the moderators assessed were implementation site and patient activation measure. RESULTS:Content adherence was high for three components with nearly 80.0% of patients setting ≥ 1 goal, having ≥ 1 PC visit and receiving ≥ 1 education session. Only 45.0% patients received ≥ 1 SDH referral. After adjusting for patient gender, language, race, ethnicity, and age, the implementation site moderated adherence to goal setting (77.4% BH vs. 87.7% VA), educational coaching (78.9% BH vs. 88.3% VA), number of successful CHW-patient encounters (6 BH vs 4 VA) and percent of patients receiving all four components (41.1% BH vs. 25.7% VA). CONCLUSIONS:The fidelity to the four CHORD intervention components differed between the two implementation sites, demonstrating the challenges in implementing complex evidence-based interventions in different settings. Our findings underscore the importance of measuring implementation fidelity in contextualizing the outcomes of randomized trials of complex multi-site behavioral interventions. TRIAL REGISTRATION:The trial was registered with on 30/12/2016 and the registration number is NCT03006666 .
PMID: 36978071
ISSN: 1471-2458
CID: 5454102

In adults with delirium in the ICU, haloperidol did not increase number of days alive out of the hospital at 90 d [Comment]

Tanner, Michael
Andersen-Ranberg NC, Poulsen LM, Perner A, et al. Haloperidol for the treatment of delirium in ICU patients. N Engl J Med. 2022;387:2425-35. 36286254.
PMID: 36877976
ISSN: 1539-3704
CID: 5448602

USPSTF recommends against beta carotene or vitamin E supplements for preventing CVD or cancer in adults [Comment]

Tanner, Michael
SOURCE CITATION:JAMA. 2022;327:2326-33. 35727271.
PMID: 36191318
ISSN: 1539-3704
CID: 5351412

In diabetes, some statins reduce non-HDL-C better than others vs. placebo

Tanner, Michael
SOURCE CITATION/UNASSIGNED:BMJ. 2022;376:e067731. 35331984.
PMID: 35914251
ISSN: 1539-3704
CID: 5287862

Antihypertensive drugs reduced risk for new-onset type 2 diabetes; effect varies by antihypertensive class [Comment]

Tanner, Michael
SOURCE CITATION:Lancet. 2021;398:1803-10. 34774144.
PMID: 35377716
ISSN: 1539-3704
CID: 5216822

In high-risk persons, lung cancer screening with CT vs. no or CXR screening reduces lung cancer mortality

Tanner, Michael
SOURCE CITATION/UNASSIGNED:J Clin Oncol. 2021;39:2574-85. 34236916.
PMID: 34724401
ISSN: 1539-3704
CID: 5037852

USPSTF recommends against screening adults in the general population for asymptomatic carotid artery stenosis

Tanner, Michael
SOURCE CITATION/UNASSIGNED:JAMA. 2021;325:476-81. 33528542.
PMID: 34058106
ISSN: 1539-3704
CID: 4924382

In type 2 diabetes, SGLT2 inhibitors reduce all-cause, but not cardiovascular, mortality vs. GLP-1 RAs

Tanner, Michael
SOURCE CITATION/UNASSIGNED:BMJ. 2021;372:m4573. 33441402.
PMID: 34058114
ISSN: 1539-3704
CID: 4924392