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Insulin Secretion Defects in Low Body Mass Index (BMI) Diabetes [Meeting Abstract]

Dasgupta, Riddhi; Goyal, Akankasha; Wickramanayake, Anneka; Kocherlakota, Chaithanya Murthy; Thomas, Nihal; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677282

Association between Low Body Mass Index (BMI) and Insulin Sensitivity [Meeting Abstract]

Goyal, Akankasha; Wickramanayake, Anneka; Viswanathan, Shankar; Dasgupta, Riddhi; Inbakumari, Mercy; Kocherlakota, Chaithanya Murthy; Gangadhara, Praveen; Thomas, Nihal; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677292

Surrogate measures of insulin sensitivity when compared to euglycemic hyperinsulinemic clamp studies in Asian Indian men without diabetes

Venkatesan, Padmanaban; Tiwari, Akankasha; Dasgupta, Riddhi; Carey, Michelle; Kehlenbrink, Sylvia; Wickramanayake, Anneka; Jambugulam, Mohan; Jeyaseelan, Lakshmanan; Ramanathan, Kavitha; Hawkins, Meredith; Thomas, Nihal
AIM: Fasting surrogate measures of insulin sensitivity are increasingly used in research and clinical practice. To assess the reliability of these measures, we aimed to evaluate multiple fasting surrogate measures simultaneously in non-diabetic subjects in comparison with the euglycemic hyperinsulinemic clamp study. METHODS: Sixteen normoglycemic male South Indian subjects were studied. After an overnight fast, blood samples were collected for glucose, insulin and lipid profile measurements, and stepped euglycemic hyperinsulinemic clamp studies were performed on all subjects. Steady state glucose infusion rates (M value) during low and high insulin phases of the clamp were calculated. Correlation of M value with surrogate markers of insulin sensitivity was performed. Predictive accuracy of surrogate indices was measured in terms of Root Mean Squared Error (RMSE) and leave-one-out cross-validation-type RMSE of prediction using a calibration model. RESULTS: M values showed a strong and significant correlation (p<0.01) with the following surrogate markers: Fasting insulin (r=-0.714), Fasting glucose to insulin ratio (FGIR, r=0.747) and Raynaud index (r=0.714). FGIR had a significantly lower RMSE when compared with HOMA-IR and QUICKI. CONCLUSIONS: Among the surrogate measures, FGIR had the strongest correlation with M values. FGIR was also the most accurate surrogate measure, as assessed by the calibration model.
PMID: 26718937
ISSN: 1873-460x
CID: 2285652

Central Regulation of Endogenous Glucose Production Is Impaired in Type 2 Diabetes Mellitus [Meeting Abstract]

Carey, Michelle; Esterson, Yonah; Boucai, Laura; Raghavan, Pooja; Zhang, Kehao; Mehta, Deeksha; Kehlenbrink, Sylvia; Koppaka, Sudha; Tiwari, Akankasha; Wu, Licheng; Schwartz, Gary J; Kishore, Preeti; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677332

Defining the Metabolic Phenotype of Malnutrition-associated Diabetes [Meeting Abstract]

Tiwari, Akankasha; Das Gupta, Riddhi; Kehlenbrink, Sylvia; Carey, Michelle; Wickramanayake, Anneka; Kocherlakota, Chaithanya Murthy; Jambugulam, Mohan; Nihal, Padmanaban V; Thomas, J; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677342

Dose-dependent Effects of Vitamin D on Insulin Sensitivity and Adipose Tissue Inflammation [Meeting Abstract]

Zhang, Kehao; Tiwari, Akankasha; Carey, Michelle; Sandu, Oana A; Kishore, Preeti; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677352

Defining the Pathophysiology of Low Body Mass Index Diabetes [Meeting Abstract]

Tiwari, Akankasha; Das Gupta, Riddhi; Wickramanayake, Anneka; Carey, Michelle; Padmanaban, V; Jambugulam, Mohan; Kocherlakota, Chaithanya; Jayatillake, Harsha; Stein, Daniel T; Thomas, Nihal J; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677362


Tiwari, Akankasha; Zhang, Kehao; Carey, Michelle; Hawkins, Meredith; Kishore, Preeti
ISSN: 1708-8267
CID: 2677322

Underutilization of Diabetes Education. Experience in an Urban Teaching Hospital in The Bronx

Torres, Edwin A; Tiwari, Akankasha; Movsas, Sharon; Carrasqukllo, Iris; Zonszein, Joel
Objective: Patient education is a fundamental component of diabetes management. Few studies have evaluated the "real life" frequency and impact of diabetes education. This study, conducted in a large teaching hospital in Bronx, New York, focused on a variety of diabetes educational programs in order to assess their utilization by patients and their individual impact. Research design and methods: Face-to-face interviews were conducted with a convenience sample of patients with type 2 diabetes, both inpatient and outpatient, by registered nurses or physicians. Information about demographics, type of education provided, and patient knowledge of hemoglobin A1C (A1C), lipids, and blood pressure co1ntrol was obtained using a questionnaire. Results: Seventy-four adult patients were interviewed between January 2013 and December 2013. Education was provided to 38% of the sample with a similar distribution among inpatients (38%) and outpatients (33%). The majority received one-to-one "unstructured education." Education had no impact on knowledge and/or clinical parameters. No differences were found among the A1C values between those that received and did not receive education (A1C 8.6% vs 8.3%), or among those hospitalized (A1C 8%) versus treated as outpatients (A1C 8.4%). Similarly, LDL-cholesterol did not differ between those who received and did not receive education (85 mg/dl vs 89 mg/dl respectively). Conclusion: Despite ample availability of educational programs in a large urban teaching medical center, most patients did not receive education, and when provided, it was unstructured. We identified and discussed potential barriers that may have contributed to the underutilization and quality of education. However, there remains an opportunity to increase the use of and improve the quality of diabetes education
ISSN: 2381-201x
CID: 2677222

Resveratrol Improves Insulin Resistance without Affecting Muscle Mitochondria in Overweight Humans [Meeting Abstract]

Maginley, Roger; Zhang, Kehao; Carey, Michelle; Goyal, Akankasha; Kehlenbrink, Sylvia; Sandu, Oana; Dong, Xinyuan; Crandall, Jill; Kishore, Preeti; Hawkins, Meredith
ISSN: 1939-327x
CID: 2677262