Try a new search

Format these results:

Searched for:



Total Results:


Impact of radiotherapy on palliative gastroenterostomy in pancreatic cancer

Skibber, J M; Weiss, S M; Mohiuddin, M; Rosato, F E
The previously unaddressed impact of radiotherapy and vagotomy on palliative gastroenterostomy (GE) in patients with unresectable pancreatic cancer was studied. Sixty-eight patients were retrospectively evaluated. A higher overall incidence of complications was found in the group (N = 44) undergoing irradiation as well as gastroenterostomy compared to a group undergoing gastroenterostomy alone. The increased complications were due to 16 episodes of bleeding among the irradiated patients. Rates of obstructive complications were similar for both groups (20%). Rates of bleeding were highest among patients undergoing prophylactic GE and irradiation compared to those receiving GE alone. Vagotomy in 12 patients who were irradiated did not appear to protect against bleeding. We found the irradiated prophylactic GE to provide poor palliation in patients with unresectable pancreatic cancer and recommend it not be performed if radiotherapy is to be used for attempt in local control of unresectable pancreatic cancer.
PMID: 2416277
ISSN: 0003-4932
CID: 2193272

Rapid intra-abdominal spread of pancreatic cancer. Influence of multiple operative biopsy procedures

Weiss, S M; Skibber, J M; Mohiuddin, M; Rosato, F E
Intra-abdominal spread of tumor is a common cause of treatment failure in patients with pancreatic cancer. We have reviewed 62 patients with pancreatic cancer undergoing repeat laparotomy in order to learn what factors are associated with the high risk of intra-abdominal metastases. Patients who underwent two or more operative biopsy procedures were at a markedly increased risk of developing intra-abdominal tumor seeding. These metastases were not detectable by preoperative computed tomography scan or ultrasound. This information affirms that multiple biopsies of pancreatic tumors increase the risk of local disease failure, and regimens based on nonoperative staging are likely to incorrectly minimize the extent of tumor involvement.
PMID: 3985784
ISSN: 0004-0010
CID: 2193282

Bowel obstruction in cancer patients: performance status as a predictor of survival

Weiss, S M; Skibber, J M; Rosato, F E
Ninety-five patients with known cancer who developed bowel obstruction were reviewed in an effort to evaluate the reliability of preadmission performance status as a predictor of outcome of therapy. Based on the review, a number of conclusions can be reached. Performance status, which is more easily measured than stage of disease at admission, is correlated with successful resolution of obstruction and survival. Many patients with known cancer who develop bowel obstruction have a nonmalignant cause of obstruction. Prolonged nonoperative treatment of cancer patients with bowel obstruction is unlikely to be successful and is fraught with complications.
PMID: 6694387
ISSN: 0022-4790
CID: 2193292

Task Force 3: The physician in the work setting (industrial/occupational medicine)

Eliot, R S; Bond, M B; Brandenburg, R O; Cooper, T; Crumrine, J L; Glasser, M A; Hafner, D; Herd, J A; Hollen, G E; Kerr, L E; Sherwin, R; Resnekov, L; Roberts, N J; Simmons, H E; Sparks, R D; Weiss, S M
PMID: 7008574
ISSN: 0002-9149
CID: 1451912