Faculty Bibliography
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9
Back to the Bottle: Comparison of Palatoplasty Outcomes Before and After Systematic Changes to Postoperative Precaution Protocols
MAIN OBJECTIVE/OBJECTIVE:To analyze postoperative palatoplasty outcomes before and after systemic protocol changes to preferred bottle and arm immobilizer use after surgery. DESIGN/METHODS:Retrospective, cohort study. SETTING/METHODS:Urban, academic, tertiary medical center in New York City, NY. PARTICIPANTS/METHODS:= 39). INTERVENTIONS/METHODS:Protocols were amended over the 2018 calendar year to allow for utilization of the baby's preferred bottle (vs alternative feeding methods) and hand socks (vs arm immobilizers) in the immediate postoperative period. Data was extrapolated from electronic medical records to compare surgical outcomes. MAIN OUTCOME MEASURES/METHODS:Postoperative wound complications (fistula and dehiscence) that did not resolve within 1 month, length of stay (hours), and 30-day re-admission. Nonparametric Mann-Whitney U tests and Fisher's Exact test were utilized for statistical analysis. RESULTS: = .366). CONCLUSIONS:The findings from this study suggest relaxing postoperative protocols following palatoplasty to allow immediate bottle feedings and unrestricted arm use may be safe without compromise to surgical outcomes.
PMID: 39692124
ISSN: 1545-1569
CID: 5764442
Common Conditions of the Hand for the Nurse Practitioner: How to Diagnose, How to Manage, and When to Refer to a Hand Surgeon
In many parts of the United States, a plastics-trained hand surgeon can be in limited supply. Depending on individual state law, nurse practitioners can manage common and moderately complex hand conditions, the undertaking of which requires extensive training, high command of the anatomy, and knowing when referral is necessary.
PMID: 29494411
ISSN: 1550-1841
CID: 3082402
The comparison of five studies with mixed approaches to reduce postoperative
ORIGINAL:0015398
ISSN: 2577-4301
CID: 5102722
Mission Haiti: 2013
ORIGINAL:0015400
ISSN: n/a
CID: 5102752
Large-scale gene-centric analysis identifies novel variants for coronary artery disease
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p<10(-33); LPA:p<10(-19); 1p13.3:p<10(-17)) as well as three recently discovered loci (COL4A1/COL4A2, ZC3HC1, CYP17A1:p<5×10(-7)). However, we found essentially null results for most previously suggested CAD candidate genes. In our replication study of 24 promising common variants, we identified novel associations of variants in or near LIPA, IL5, TRIB1, and ABCG5/ABCG8, with per-allele odds ratios for CAD risk with each of the novel variants ranging from 1.06-1.09. Associations with variants at LIPA, TRIB1, and ABCG5/ABCG8 were supported by gene expression data or effects on lipid levels. Apart from the previously reported variants in LPA, none of the other ∼4,500 low frequency and functional variants showed a strong effect. Associations in South Asians did not differ appreciably from those in Europeans, except for 9p21.3 (per-allele odds ratio: 1.14 versus 1.27 respectively; P for heterogeneity = 0.003). This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.
PMID: 21966275
ISSN: 1553-7404
CID: 5479352
Nursing education
ORIGINAL:0015397
ISSN: 0028-7644
CID: 5102712
Turtlequill : University of Rochester School of Medicine's Journal of the Literary Arts. 2009:7:11-12.DOI:
Clare Dennison speech
ORIGINAL:0015399
ISSN: n/a
CID: 5102732
CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes [Case Report]
Brooke-Spiegler syndrome (BSS), familial cylindromatosis (FC), and multiple familial trichoepithelioma (MFT), originally described as distinct inherited disorders, are characterized by a variety of skin appendage neoplasms. Mutations in the CYLD gene are found in individuals with these syndromes. We describe a single family with affected members exhibiting either the FC or the MFT phenotypes associated with a mutation in the CYLD gene. These findings support the notion that BSS, FC, and MFT represent phenotypic variation of a single defect. Of interest, one of the affected individuals described in this report exhibits a severe phenotype illustrating the morbidity of the disorder.
PMID: 16922728
ISSN: 0009-9163
CID: 5181192
Environmental enrichment reverses the impaired explorative behavior and altered gene expression induced by early-life seizures [Meeting Abstract]
ISI:000224420101058
ISSN: 0013-9580
CID: 5102702
