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Intimate partner violence and asthma in pediatric and adult populations

Wang, Eileen; Zahid, Soombal; Moudgal, Anita N; Demaestri, Sabrina; Wamboldt, Frederick S
OBJECTIVE:To evaluate the relationship between intimate partner violence (IPV) and adult and childhood asthma outcomes. DATA SOURCES:We conducted a systematic literature review using 4 databases (PubMed, Ovid MEDLINE, Ovid Embase, and Ovid PsycINFO) with asthma and IPV-associated terms. STUDY SELECTIONS:We included published studies, available in English, to October 2021, which included IPV as an exposure and asthma as an outcome. Both adult and pediatric populations were included in the following settings: community, health care, and home. RESULTS:There were 37 articles identified. There was evidence among multiple studies to support increased prevalence of asthma in adults exposed to IPV and prevalence and incidence in children with parental IPV exposure. There were fewer studies evaluating IPV exposure and adult asthma morbidity, but they found statistically significant associations between IPV and increased rate of asthma exacerbations and worsened asthma control. There was sparse evidence evaluating a relationship between IPV and adult asthma mortality. There were no studies identified evaluating IPV and childhood asthma morbidity or mortality. CONCLUSION:The association between IPV and increased asthma prevalence, incidence, and worsened morbidity merits recognition and further investigation into potential mechanisms. Health care providers can implement practical strategies to help mitigate the negative effects of IPV on health and asthma. These include addressing potential impactful biopsychosocial factors and comorbidities, implementing routine screening and referrals, and partnering with community advocacy organizations. Given their positions of respect and power in society, health care providers can have lasting impacts on the lives of pediatric and adult patients affected by IPV.
PMID: 34995784
ISSN: 1534-4436
CID: 5285372

Unique Nasal Epithelial Transcriptome Changes Discovered in AERD [Meeting Abstract]

Zahid, Soombal; Babbel, Justin; Luskin, Kathleen; Thakrar, Hiral; Katial, Rohit; White, Andrew; Hoyte, Flavia; Modena, Brian
ISSN: 0091-6749
CID: 5286002

Poor control of asthma symptoms with interleukin-5 inhibitors in four patients with aspirin-exacerbated respiratory disease [Letter]

Eid, Ryan C; Wudneh, Eden; Zahid, Soombal; Cahill, Katherine; Jerschow, Elina
PMID: 31605753
ISSN: 1534-4436
CID: 5285362


Zahid, S.; Alam, R.
ISSN: 1081-1206
CID: 5286012

Combatting Inappropriate Allergy Alert Overrides [Meeting Abstract]

Zahid, Soombal; Piotrowski, Annette
ISSN: 0091-6749
CID: 5286022

Improving Patient Education And Communication Through Teach-back: The Implementation Of Inpatient Discharge Surveys [Meeting Abstract]

Zahid, Soombal; Kambo, Varinder; Ilyas, Nazish; Wong, Jay
ISSN: 1553-5606
CID: 5286042

VTE Prophylaxis in Hospitalized Medicine Patients: Too Much of a Good Thing? [Meeting Abstract]

Zahid, S.; Mazurkiewicz, R.; Kirschenbaum, L.
ISSN: 1073-449x
CID: 5285952

A Rare Case of HIV-Induced Inflammatory Demyelinating Polyneuropathy

Sajan, Abin; Zahid, Soombal; Stumph, Jordan; Griepp, Daniel; Saba, Sami; Ilyas, Nazish; McFarlane, Isabel M
Background:Acute inflammatory demyelinating polyneuropathy (AIDP) is an uncommon form of neuropathy in HIV-infected patients that can cause pain, sensory disturbance, and motor weakness. Case presentation:A 23-year-old African American male with past medical history of Guillain-Barre Syndrome (GBS), Lyme disease, and sexually transmitted infections including syphilis and chlamydia presented with acute back pain radiating to bilateral lower extremities with worsening right foot weakness for four days. Cerebrospinal fluid (CSF) studies including meningoencephalitis panel were negative as well as blood tests for Lyme disease and HIV antibody testing. Patient was initially treated with penicillin for positive treponemal serology but without improvement in lower extremity weakness. Electromyogram showed evidence of early demyelinating motor polyneuropathy. Four days after presentation, repeat HIV antibody testing returned positive. Recurrent AIDP in this case was suspected to be secondary to acute HIV infection, and highly active antiretroviral therapy (HAART) was administered along with intravenous immunoglobulin (IVIG). Muscle strength improved with therapy and patient was expected to have continued improvement with intensive rehabilitation after discharge. Conclusion:Acute inflammatory demyelinating polyneuropathy (AIDP) tends to present early in course of HIV infection. Therefore, HIV testing should be obtained in individuals presenting with new neurological deficits. Our patient received HAART therapy, in addition to the traditional modalities to manage AIDP, which led to a substantial recovery of his sensorimotor function.
PMID: 30899779
ISSN: 2374-216x
CID: 5285352

Managing Cancer-Related Pain: A Look at Alternative Approaches

Zahid, Soombal; Koa, Johnny; Goldstein, Leonard
ISSN: 1541-5988
CID: 5286032

Esophagus and Contralateral Lung-Sparing IMRT for Locally Advanced Lung Cancer in the Community Hospital Setting

Kao, Johnny; Pettit, Jeffrey; Zahid, Soombal; Gold, Kenneth D; Palatt, Terry
BACKGROUND:The optimal technique for performing lung IMRT remains poorly defined. We hypothesize that improved dose distributions associated with normal tissue-sparing IMRT can allow safe dose escalation resulting in decreased acute and late toxicity. METHODS:We performed a retrospective analysis of 82 consecutive lung cancer patients treated with curative intent from 1/10 to 9/14. From 1/10 to 4/12, 44 patients were treated with the community standard of three-dimensional conformal radiotherapy or IMRT without specific esophagus or contralateral lung constraints (standard RT). From 5/12 to 9/14, 38 patients were treated with normal tissue-sparing IMRT with selective sparing of contralateral lung and esophagus. The study endpoints were dosimetry, toxicity, and overall survival. RESULTS:Despite higher mean prescribed radiation doses in the normal tissue-sparing IMRT cohort (64.5 vs. 60.8 Gy, p = 0.04), patients treated with normal tissue-sparing IMRT had significantly lower lung V20, V10, V5, mean lung, esophageal V60, and mean esophagus doses compared to patients treated with standard RT (p ≤ 0.001). Patients in the normal tissue-sparing IMRT group had reduced acute grade ≥3 esophagitis (0 vs. 11%, p < 0.001), acute grade ≥2 weight loss (2 vs. 16%, p = 0.04), and late grade ≥2 pneumonitis (7 vs. 21%, p = 0.02). The 2-year overall survival was 52% with normal tissue-sparing IMRT arm compared to 28% for standard RT (p = 0.015). CONCLUSION/CONCLUSIONS:These data provide proof of principle that suboptimal radiation dose distributions are associated with significant acute and late lung and esophageal toxicity that may result in hospitalization or even premature mortality. Strict attention to contralateral lung and esophageal dose-volume constraints are feasible in the community hospital setting without sacrificing disease control.
PMID: 26157703
ISSN: 2234-943x
CID: 5285342